Phenotype News and Research

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Researchers design one-step procedure for improving effective of adoptive cell immunotherapy against solid tumors

Researchers developed a one-step method to engineer multifunctional M1 phenotype macrophages.

14 Aug 2023

Study explores the use of existing medicines to revolutionize cancer treatment

In a recent study published in the journal of Genes & Diseases, Research team led by Lu explores the potential for the use of FDA-approved hypertension and EMA-approved cough medicines to revolutionize cancer treatment.

10 Aug 2023

What are some recent advancements in proteomics-driven pancreatic oncology research?

The application of proteomics-driven biomarkers for early detection, diagnosis, and treatment of pancreatic cancer.

9 Aug 2023

Spatially-resolved macrophage phenotyping in liver disease-related research

This review manuscript highlights the relevance of spatially-resolved macrophage phenotyping in liver disease-related research.

8 Aug 2023

NLRP3 inflammasome plays a role in podocyte aging

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 14, entitled, "Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span."

8 Aug 2023

RAGE plays key role in cellular mechanisms of plasticity in aggressive triple-negative breast cancer

Published online ahead of print in the journal Oncogene , a study led by Josep Villanueva, an Investigator at the Vall d'Hebron Institute of Oncology (VHIO), shows that the receptor for advanced glycation end-product (RAGE) plays a key role in cellular mechanisms of plasticity in mesenchymal triple-negative breast cancer (TNBC) that transform epithelial cells into mesenchymal cells as potent drivers of cancer cell proliferation and tumor invasion.

8 Aug 2023

Identification of plasma proteins associated with ovarian cancer risk

Researchers performed proteomic Mendelian randomization as well as co-localization analyses to identify drug targets for ovarian cancer.

8 Aug 2023

Unexpected link between pure mathematics and genetics discovered

An interdisciplinary team of mathematicians, engineers, physicists, and medical scientists have uncovered an unexpected link between pure mathematics and genetics, that reveals key insights into the structure of neutral mutations and the evolution of organisms.

8 Aug 2023

Is COVID-19 vaccination linked to psoriasis emergence or flare-ups?

Researchers explored the relationship between COVID-19 vaccination and psoriasis onset or exacerbation.

7 Aug 2023

Researchers discover how aging can lead to chronic metabolic disorders

Korean researchers have unveiled a novel signaling pathway that fosters aging-related chronic metabolic disorders.

3 Aug 2023

Surprising new role for a key immune regulator revealed

A signaling protein known as STING is a critical player in the human immune system, detecting signs of danger within cells and then activating a variety of defense mechanisms.

3 Aug 2023

The mechanisms of triptan using metabolomics and transcriptomics in spontaneous migraine attacks

Researchers discuss the mechanisms of triptans for the treatment of spontaneous migraine attacks by using transcriptomics and metabolomics.

3 Aug 2023

Uncommon genetic allele variants may play a vital role in treatment-resistant depression, finds study

The association between treatment-resistant depression and uncommon functional genetic alleles.

3 Aug 2023

UC San Diego team reports new insights on pelvic floor muscle dysfunction

University of California San Diego researchers are leading a team reporting new insights in Science Translational Medicine on pelvic floor muscle (PFM) dysfunction, which is one of the key risk factors for pelvic floor disorders which impact close to a quarter of women in the U.S.

2 Aug 2023

Study provides new insights into the intricate cellular processes driving heterotopic ossification

In a new study published on 21 July 2023 by the journal Bone Research, a team of researchers from Johns Hopkins University, using a combination of lineage tracing and single-cell RNA sequencing (scRNA-seq), delved into the contribution of synovial/tendon sheath progenitor cells to heterotopic bone formation.

1 Aug 2023

Research reveals surprising genetic overlap between neurological and psychiatric disorders

Researchers compared the shared genetic risk and biological foundations of neurological and mental illnesses.

1 Aug 2023

The microbiota connection, gut health linked to metabolic syndrome prevalence

The relationship between gut microbiota and metabolic disorders focused on BA metabolism and immunity.

1 Aug 2023

MU researcher receives $3 million grant to use gene editing for investigating the building blocks of disease

In a new study funded by a $3 million grant from the National Institutes of Health (NIH), University of Missouri researcher Kiho Lee, an associate professor in the College of Agriculture, Food and Natural Resources, will use gene editing to investigate the building blocks of disease.

27 Jul 2023

KIAA0930 could be a novel therapeutic target for cancer cachexia

A new research paper was published in Oncotarget's Volume 14 on July 20, 2023, entitled, "The uncharacterized transcript KIAA0930 confers a cachexic phenotype on cancer cells."

26 Jul 2023

Research uncovers new insights into post-COVID-19 syndrome (PCS) phenotypes and impact on quality of life

Researchers assessed post-coronavirus disease 2019 (COVID-19) syndrome (PCS) prevalence and severity.

26 Jul 2023

Phenotype News and Research

Researchers design one-step procedure for improving effective of adoptive cell immunotherapy against solid tumors

Study explores the use of existing medicines to revolutionize cancer treatment

What are some recent advancements in proteomics-driven pancreatic oncology research?

Spatially-resolved macrophage phenotyping in liver disease-related research

NLRP3 inflammasome plays a role in podocyte aging

RAGE plays key role in cellular mechanisms of plasticity in aggressive triple-negative breast cancer

Identification of plasma proteins associated with ovarian cancer risk

Unexpected link between pure mathematics and genetics discovered

Is COVID-19 vaccination linked to psoriasis emergence or flare-ups?

Researchers discover how aging can lead to chronic metabolic disorders

Surprising new role for a key immune regulator revealed

The mechanisms of triptan using metabolomics and transcriptomics in spontaneous migraine attacks

Uncommon genetic allele variants may play a vital role in treatment-resistant depression, finds study

UC San Diego team reports new insights on pelvic floor muscle dysfunction

Study provides new insights into the intricate cellular processes driving heterotopic ossification

Research reveals surprising genetic overlap between neurological and psychiatric disorders

The microbiota connection, gut health linked to metabolic syndrome prevalence

MU researcher receives $3 million grant to use gene editing for investigating the building blocks of disease

KIAA0930 could be a novel therapeutic target for cancer cachexia

Research uncovers new insights into post-COVID-19 syndrome (PCS) phenotypes and impact on quality of life

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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