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Moderna and Pfizer-BioNTech vaccines induce robust T cell response against SARS-CoV-2 variants

Researchers in the United States have conducted a study showing the efficacy of the Moderna and Pfizer-BioNTech vaccines at eliciting a robust T cell response against variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

16 May 2021

Sepsis can cause alterations in the functioning of defense cells that lead to death

An article published in Frontiers in Immunology suggests that sepsis can cause alterations in the functioning of defense cells that persist even after the patient is discharged from hospital.

12 May 2021

Cerebral organoids provide new insight into role of key enzyme in natural brain development

Like many around the world, the lab of Professor Mriganka Sur in The Picower Institute for Learning and Memory at MIT has embraced the young technology of cerebral organoids, or "minibrains," for studying human brain development in health and disease.

11 May 2021

Study provides new insight on how HER2-low tumors may evolve in breast cancer patients

The finding that breast tumors can evolve to express low HER2 potentially widens the number of patients who can benefit from new investigational agents, typically novel antibody-drug conjugate therapies, that are currently in clinical trials for HER2-low tumors.

8 May 2021

Human organoids useful for modeling COVID-19 variants of concern, finds study

A new study published on the bioRxiv* preprint server found that using human organoids could help with better characterizing the phenotype of several viral variants, including B.1.1.7. Their findings show the ribonucleic acid (RNA) shedding of the SARS-CoV-2 variant correlated with viral fitness and infectiousness.

7 May 2021

Aberrant immune features in healthy elderly and male subjects with severe COVID-19 may predate infection

A new study shows that the immunological features of severe COVID-19 are already present in healthy older adults and in men, before they are infected, indicating a possible explanation for this differential susceptibility towards the virus.

6 May 2021

Class I HLA alleles shape CD8+ T cell repertoire in SARS-CoV-2 infection

An interesting new study discusses how adaptive cellular immunity against the SARS-CoV-2 is dependent on differences in HLA-encoding genes between patients.

3 May 2021

International task force questions the applicability, relevance of current Parkinson's disease subtyping

The clinical presentation and underlying biology of Parkinson's disease (PD) varies significantly, but attempts to cluster cases into a limited number of subtypes have questionable applicability and relevance, reports the international Task Force for PD Subtypes in the Journal of Parkinson's Disease.

30 Apr 2021

Algorithm interprets data from electronic medical records to diagnose kidney disease

Diagnosing chronic kidney disease, which is often undetected until it causes irreversible damage, may soon become automated with a new algorithm that interprets data from electronic medical records.

29 Apr 2021

A new roadmap for advancing TBI care

Brain research and advocacy nonprofit Cohen Veterans Bioscience (CVB) today announced the launch of a National TBI Precision Solutions Research Roadmap, with the advent of the first in a series of publications resulting from its Brain Trauma Blueprint framework program.

26 Apr 2021

Researchers to apply smartphone apps to manage anxiety, depression in breast cancer patients

Home sensors to monitor cancer patients' pain. A smartphone app to manage breast cancer patients' anxiety and depression. And $12 million in new grant funding to pay for even more health care advances, earned from just a $2 million initial investment.

23 Apr 2021

SARS-CoV-2-associated ssRNAs trigger inflammation and immunity via toll-like receptors

Severe COVID-19 causes sepsis-like manifestations, intense lung injury, and multi-organ failure, all associated with the overproduction of pro-inflammatory cytokines. This "cytokine storm" directly correlates with poor prognosis in this subgroup of patients.

21 Apr 2021

Study provides the first extensive genetic and phenotype landscape of peripartum cardiomyopathy

Researchers at Penn Medicine have identified more genetic mutations that strongly predispose younger, otherwise healthy women to peripartum cardiomyopathy (PPCM), a rare condition characterized by weakness of the heart muscle that begins sometime during the final month of pregnancy through five months after delivery.

20 Apr 2021

Study sheds new light on the ability of pancreatic cancer cells to metastasize

With an overall survival rate of 9% for those diagnosed, pancreatic cancer remains exceedingly difficult to treat. However, the patient's primary tumor typically isn't what leads to death - it is the cancer's ability to evade detection and metastasize to other organs.

19 Apr 2021

Researchers identify two distinct phenotypes of COVID-19-associated ARDS

Approximately one in four patients hospitalized for the acute respiratory distress syndrome (ARDS) associated with severe COVID-19 infections may have a distinct phenotype (disease presentation) or biochemical profile associated with organ dysfunction, blood-clotting abnormalities and greater risk of death than patients with other, seemingly similar forms of the disease, researchers at Massachusetts General Hospital have found.

15 Apr 2021

Early exposure to air pollutant may contribute to non-atopic childhood asthma

Asthma afflicts more than 300 million people worldwide. The most severe manifestation, known as non-Th2, or non-atopic childhood asthma, represents the majority of the cases, greater than 85%, particularly in low-income countries, according to Hyunok Choi, an associate professor at the Lehigh University College of Health.

15 Apr 2021

Phase II of Singapore's National Precision Medicine strategy to begin in April 2021

Precision medicine is part of Singapore's Research, Innovation and Enterprise (RIE) 2025 strategic goal to transform and protect the health of every Singaporean.

7 Apr 2021

Finding ways to reverse a genetic cause of poor stress responses in mice

Everyone faces stress occasionally, whether in school, at work, or during a global pandemic. However, some cannot cope as well as others.

7 Apr 2021

UCI receives $4.2 million grant to study sporadic inclusion body myositis affecting aging adults

The National Institute of Arthritis and Musculoskeletal and Skin Diseases has awarded UCI a 5-year, $4.2 million grant to study sporadic inclusion body myositis (sIBM), which affects aging adults causing asymmetric muscle weakness and severe disability. The disease is currently untreatable and poorly understood.

6 Apr 2021

Researchers evaluate new drug for spinal muscular atrophy in a broader spectrum of patients

The rarity of spinal muscular atrophy (SMA) means that promising new treatments may be tested in only a limited spectrum of patients before approval. Investigators evaluated a newly approved drug, onasemnogene abeparvovec, in a broader spectrum of patients in order to obtain expanded data on its side effects profile.

6 Apr 2021

Phenotype News and Research

Moderna and Pfizer-BioNTech vaccines induce robust T cell response against SARS-CoV-2 variants

Sepsis can cause alterations in the functioning of defense cells that lead to death

Cerebral organoids provide new insight into role of key enzyme in natural brain development

Study provides new insight on how HER2-low tumors may evolve in breast cancer patients

Human organoids useful for modeling COVID-19 variants of concern, finds study

Aberrant immune features in healthy elderly and male subjects with severe COVID-19 may predate infection

Class I HLA alleles shape CD8+ T cell repertoire in SARS-CoV-2 infection

International task force questions the applicability, relevance of current Parkinson's disease subtyping

Algorithm interprets data from electronic medical records to diagnose kidney disease

A new roadmap for advancing TBI care

Researchers to apply smartphone apps to manage anxiety, depression in breast cancer patients

SARS-CoV-2-associated ssRNAs trigger inflammation and immunity via toll-like receptors

Study provides the first extensive genetic and phenotype landscape of peripartum cardiomyopathy

Study sheds new light on the ability of pancreatic cancer cells to metastasize

Researchers identify two distinct phenotypes of COVID-19-associated ARDS

Early exposure to air pollutant may contribute to non-atopic childhood asthma

Phase II of Singapore's National Precision Medicine strategy to begin in April 2021

Finding ways to reverse a genetic cause of poor stress responses in mice

UCI receives $4.2 million grant to study sporadic inclusion body myositis affecting aging adults

Researchers evaluate new drug for spinal muscular atrophy in a broader spectrum of patients

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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