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Research redefines rheumatoid arthritis: Over 314,000 cells analyzed for precise treatment strategies

A new paper recently published in Nature, reported the examination of synovial tissue from the joints of nearly 80 people with RA, in combination with RNA sequencing and surface protein analyses.

10 Nov 2023

How glucose restriction makes lung cancer cells more aggressive

One of the hallmarks of cancer cell development is its dependence on sugar, especially glucose, to grow and divide.

7 Nov 2023

Study validates first-in-class AI-driven digital pathology colorectal cancer diagnostic tool

In a peer-reviewed study published today in Nature Communications, a team of scientists from French-American techbio Owkin and pathology labs in France present a blind validation of MSIntuit CRC, a first-in-class AI-driven digital pathology diagnostic developed by Owkin, as a pre-screening tool aimed at optimizing the precision of diagnosis and treatment of colorectal cancer.

7 Nov 2023

Study links gut bacteria single-nucleotide polymorphisms to BMI

Researchers investigated the potential implications of single-nucleotide variations in gut-residing bacterial species (microbiome) on human health.

7 Nov 2023

Yabing Chen receives NIH grants to advance vascular disease research

Yabing Chen, Ph.D., has been awarded two National Institutes of Health grants totaling more than $5 million to further her research into vascular diseases ranging from hardening of the arteries to dementia.

6 Nov 2023

Is sleep apnea the missing link between high blood pressure and Alzheimer's?

Researchers explore the links between non-dipper hypertension, obstructive sleep apnea (OSA), and Alzheimer's disease (AD). They find that OSA may cause non-dipper hypertension, a condition that exacerbates AD symptoms, but also note that treating OSA can mitigate hypertension and potentially slow AD progression.

29 Oct 2023

UTHSC researcher part of team studying obesity-cancer connection

A University of Tennessee Health Science Center (UTHSC) researcher is a member of a prestigious team that has just received a highly competitive Endeavor Award totaling $3 million from The Mark Foundation for Cancer Research.

26 Oct 2023

New software tool provides a way for safer design of genome editing

A team of researchers has developed a software tool called DANGER (Deleterious and ANticipatable Guides Evaluated by RNA-sequencing) analysis that provides a way for the safer design of genome editing in all organisms with a transcriptome.

24 Oct 2023

New "pseudo cell" formulation could revolutionize treatment of vitreoretinal diseases

Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences and Beijing Chaoyang Hospital have developed a new "pseudo cell" formulation based on self-healing microcapsule-loading exosomes to treat diverse vitreoretinal diseases.

24 Oct 2023

New study investigates the relationship between PTSD, diet, and the gut microbiome

The human gut microbiome has a significant impact on our health. Research has shown that it can influence the development and response of emotions, but the relationship between post-traumatic stress disorder (PTSD) and the gut microbiome has been unexplored.

19 Oct 2023

Arterial DNA damage contributes to vascular aging

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 19, entitled, "Reduction of double-strand DNA break repair exacerbates vascular aging."

18 Oct 2023

Kidney transplantation turns back the clock on renal aging

This recent study in the Journal of Internal Medicine reveals that kidney transplantation mitigates the effects of renal aging in chronic kidney disease patients, outperforming dialysis. The research utilized DNA methylation clocks to assess biological age, finding that age acceleration decreased one year post-transplant but remained unchanged with dialysis.

17 Oct 2023

Study highlights role of circadian clock component BMAL1 on molecular phenotype of senescent cells

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 19, entitled, "BMAL1 modulates senescence programming via AP-1."

16 Oct 2023

How does nutrition influence osteoarthritis prevention and management?

The influence of nutrition on osteoarthritis (OA).

16 Oct 2023

Is it time to rethink COVID-19 boosters? New study dives into variant-specific vaccines

The study explores the efficacy of variant-adapted COVID-19 booster vaccines, particularly against new strains like Omicron. It raises questions about the need for annual updates and the best technologies for long-term, durable immunity.

15 Oct 2023

Researchers identify genes that may improve success of fecal microbe transplants

Fecal microbe transplants from healthy donors can treat patients with recurrent Clostridium difficile infections. However, after tens of thousands transplants, little was known about which donor strains provide long-term engraftment, and which engraft early after the transplant.

13 Oct 2023

Scientists identify nearly a dozen genes responsible for coronary artery calcification

An international team of scientists has identified nearly a dozen genes that contribute to calcium buildup in our coronary arteries that can lead to life-threatening coronary artery disease, a condition responsible for up to one in four deaths in the United States.

11 Oct 2023

Might a polyphenol-rich dietary approach hold the answers for managing inflammatory bowel disease?

Gut microbiota and macrophage-neutrophil interactions in the impact of dietary phenolic acids on intestinal inflammation.

11 Oct 2023

DNA aptamers: A versatile tool for regenerative medicine and beyond

Generating specific cell lineages from induced pluripotent stem cells and embryonic stem cells is the holy grail of regenerative medicine.

10 Oct 2023

Gut defenders: How T-cell intraepithelial lymphocytes guard against colon cancer

In the latest research published in Science Immunology, experts delve into the gene expression patterns of distinct intraepithelial lymphocyte populations in various gastrointestinal tract regions. Key findings reveal the roles of T-cell IELs in detecting infections and ensuring the gut's barrier integrity, with a special emphasis on their function in combating colon cancer.

9 Oct 2023

Phenotype News and Research

Research redefines rheumatoid arthritis: Over 314,000 cells analyzed for precise treatment strategies

How glucose restriction makes lung cancer cells more aggressive

Study validates first-in-class AI-driven digital pathology colorectal cancer diagnostic tool

Study links gut bacteria single-nucleotide polymorphisms to BMI

Yabing Chen receives NIH grants to advance vascular disease research

Is sleep apnea the missing link between high blood pressure and Alzheimer's?

UTHSC researcher part of team studying obesity-cancer connection

New software tool provides a way for safer design of genome editing

New "pseudo cell" formulation could revolutionize treatment of vitreoretinal diseases

New study investigates the relationship between PTSD, diet, and the gut microbiome

Arterial DNA damage contributes to vascular aging

Kidney transplantation turns back the clock on renal aging

Study highlights role of circadian clock component BMAL1 on molecular phenotype of senescent cells

How does nutrition influence osteoarthritis prevention and management?

Is it time to rethink COVID-19 boosters? New study dives into variant-specific vaccines

Researchers identify genes that may improve success of fecal microbe transplants

Scientists identify nearly a dozen genes responsible for coronary artery calcification

Might a polyphenol-rich dietary approach hold the answers for managing inflammatory bowel disease?

DNA aptamers: A versatile tool for regenerative medicine and beyond

Gut defenders: How T-cell intraepithelial lymphocytes guard against colon cancer

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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