Phenotype News and Research

RSS

Is it time to rethink COVID-19 boosters? New study dives into variant-specific vaccines

The study explores the efficacy of variant-adapted COVID-19 booster vaccines, particularly against new strains like Omicron. It raises questions about the need for annual updates and the best technologies for long-term, durable immunity.

15 Oct 2023

Researchers identify genes that may improve success of fecal microbe transplants

Fecal microbe transplants from healthy donors can treat patients with recurrent Clostridium difficile infections. However, after tens of thousands transplants, little was known about which donor strains provide long-term engraftment, and which engraft early after the transplant.

13 Oct 2023

Scientists identify nearly a dozen genes responsible for coronary artery calcification

An international team of scientists has identified nearly a dozen genes that contribute to calcium buildup in our coronary arteries that can lead to life-threatening coronary artery disease, a condition responsible for up to one in four deaths in the United States.

11 Oct 2023

Might a polyphenol-rich dietary approach hold the answers for managing inflammatory bowel disease?

Gut microbiota and macrophage-neutrophil interactions in the impact of dietary phenolic acids on intestinal inflammation.

11 Oct 2023

DNA aptamers: A versatile tool for regenerative medicine and beyond

Generating specific cell lineages from induced pluripotent stem cells and embryonic stem cells is the holy grail of regenerative medicine.

10 Oct 2023

Gut defenders: How T-cell intraepithelial lymphocytes guard against colon cancer

In the latest research published in Science Immunology, experts delve into the gene expression patterns of distinct intraepithelial lymphocyte populations in various gastrointestinal tract regions. Key findings reveal the roles of T-cell IELs in detecting infections and ensuring the gut's barrier integrity, with a special emphasis on their function in combating colon cancer.

9 Oct 2023

Is your DNA steering you towards a vegetarian diet?

Researchers using the UK Biobank identified genetic markers linked to strict vegetarianism, revealing potential connections between vegetarianism, lipid metabolism, and brain activity. The study highlighted genes, particularly those active in the brain and related to cholesterol movement, as influential in an individual's inclination towards a vegetarian lifestyle.

9 Oct 2023

Researchers explore immunomodulating targets for improving glioblastoma therapies

Researchers have delved into the intricate heterogeneity of glioblastoma, a notoriously aggressive brain tumor, using advanced single-cell RNA sequencing and innovative zebrafish avatars. Their findings spotlighted the LGALS1 gene's role in immunosuppression and suggested potential therapeutic avenues for personalized GBM treatment.

8 Oct 2023

BU professor receives grant to study endothelial cell health in cardiometabolic disease

Naomi Hamburg, MD, the Joseph A. Vita Professor of Medicine at Boston University Chobanian & Avedisian School of Medicine, has been awarded a five-year, $3.7 million grant from the National Heart, Lung and Blood Institute for her research study, "Endothelial Cell Health Across the Spectrum of Cardiometabolic Disease."

6 Oct 2023

Effectiveness of Lactobacillus in treating inflammatory bowel disease

The role of Lactobacillus in treating inflammatory bowel disease.

4 Oct 2023

Study highlights the patient heterogeneity in atopic dermatitis and demonstrates the promises of personalized treatment

Researchers investigated endotype-phenotype associations in atopic dermatitis (AD) beyond its general clinical severity.

4 Oct 2023

Trametinib: Potential therapeutic game-changer for Alzheimer's disease

Researchers developed the ATRIVIEW® platform to screen for molecules that promote differentiation neural stem cells (NSCs).

4 Oct 2023

Yeast in the gut linked to Crohn's disease inflammation, opening new doors for treatment

New study in Nature Medicine links yeast cells in the gastrointestinal tract to abnormal immune responses causing inflammation in Crohn's disease patients. The research suggests that these yeast-reactive T-cells could be a potential therapeutic target, offering new avenues for treatment.

27 Sep 2023

Arrayed CRISPR Screening for Revolutionizing Target Discovery

In this interview conducted at SLAS EU 2023 in Brussels, Belgium, we spoke to Ulrike Kuenzel, Associate Director in the Functional Genomics department at AstraZeneca about the application of arrayed CRISPR screening for target identification and more.

From Society for Laboratory Automation and Screening (SLAS) 27 Sep 2023

Is BMI the optimal adiposity marker to assess mortality risk?

Researchers evaluated adiposity markers to determine the marker with the most consistent association mortality.

25 Sep 2023

Is presence of a premenstrual disorder associated with higher risk of early menopause and menopause-related vasomotor symptoms?

A new paper explores how PMDs affect the time of menopause and the severity of vasomotor menopausal symptoms like hot flashes.

21 Sep 2023

Newborn screening for neurodevelopmental disorders may cause more harm than good

Expanding newborn screening (NBS) to include identifying genes associated with an increased risk for neurodevelopmental disorders (NDD) would cause more harm than good, according to an article published in Pediatrics.

20 Sep 2023

Researchers identify a rare cause of male infertility and discover a potential cure

Researchers investigated the genetic underpinning of asthenozoospermia, the leading cause of male fertility.

18 Sep 2023

Elite athletes bounce back strong: No long-term heart risks after COVID-19 recovery

The study finds that elite athletes who recovered from COVID-19 did not experience long-term negative effects on their cardiac health, allowing for the successful resumption of high-level sports. The findings also suggest that proper screening and medical counseling can pave the way for safe returns to sports post-COVID-19.

10 Sep 2023

Unlocking the genetic code of blood sugar reveals new diabetes risks and lung complications

The study used a genome-wide association study (GWAS) to analyze random glucose levels in nearly half a million non-diabetic subjects, uncovering 150 distinct genetic signals, including 53 new ones, linked to glycemic traits and type 2 diabetes. The research also discovered a causal effect of random glucose and type 2 diabetes on lung function, identifying lung dysfunction as a new diabetes complication.

10 Sep 2023

Phenotype News and Research

Is it time to rethink COVID-19 boosters? New study dives into variant-specific vaccines

Researchers identify genes that may improve success of fecal microbe transplants

Scientists identify nearly a dozen genes responsible for coronary artery calcification

Might a polyphenol-rich dietary approach hold the answers for managing inflammatory bowel disease?

DNA aptamers: A versatile tool for regenerative medicine and beyond

Gut defenders: How T-cell intraepithelial lymphocytes guard against colon cancer

Is your DNA steering you towards a vegetarian diet?

Researchers explore immunomodulating targets for improving glioblastoma therapies

BU professor receives grant to study endothelial cell health in cardiometabolic disease

Effectiveness of Lactobacillus in treating inflammatory bowel disease

Study highlights the patient heterogeneity in atopic dermatitis and demonstrates the promises of personalized treatment

Trametinib: Potential therapeutic game-changer for Alzheimer's disease

Yeast in the gut linked to Crohn's disease inflammation, opening new doors for treatment

Arrayed CRISPR Screening for Revolutionizing Target Discovery

Is BMI the optimal adiposity marker to assess mortality risk?

Is presence of a premenstrual disorder associated with higher risk of early menopause and menopause-related vasomotor symptoms?

Newborn screening for neurodevelopmental disorders may cause more harm than good

Researchers identify a rare cause of male infertility and discover a potential cure

Elite athletes bounce back strong: No long-term heart risks after COVID-19 recovery

Unlocking the genetic code of blood sugar reveals new diabetes risks and lung complications

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

Latest News