Phenotype News and Research

RSS

Study highlights the patient heterogeneity in atopic dermatitis and demonstrates the promises of personalized treatment

Researchers investigated endotype-phenotype associations in atopic dermatitis (AD) beyond its general clinical severity.

4 Oct 2023

Trametinib: Potential therapeutic game-changer for Alzheimer's disease

Researchers developed the ATRIVIEW® platform to screen for molecules that promote differentiation neural stem cells (NSCs).

4 Oct 2023

Yeast in the gut linked to Crohn's disease inflammation, opening new doors for treatment

New study in Nature Medicine links yeast cells in the gastrointestinal tract to abnormal immune responses causing inflammation in Crohn's disease patients. The research suggests that these yeast-reactive T-cells could be a potential therapeutic target, offering new avenues for treatment.

27 Sep 2023

Arrayed CRISPR Screening for Revolutionizing Target Discovery

In this interview conducted at SLAS EU 2023 in Brussels, Belgium, we spoke to Ulrike Kuenzel, Associate Director in the Functional Genomics department at AstraZeneca about the application of arrayed CRISPR screening for target identification and more.

From Society for Laboratory Automation and Screening (SLAS) 27 Sep 2023

Is BMI the optimal adiposity marker to assess mortality risk?

Researchers evaluated adiposity markers to determine the marker with the most consistent association mortality.

25 Sep 2023

Is presence of a premenstrual disorder associated with higher risk of early menopause and menopause-related vasomotor symptoms?

A new paper explores how PMDs affect the time of menopause and the severity of vasomotor menopausal symptoms like hot flashes.

21 Sep 2023

Newborn screening for neurodevelopmental disorders may cause more harm than good

Expanding newborn screening (NBS) to include identifying genes associated with an increased risk for neurodevelopmental disorders (NDD) would cause more harm than good, according to an article published in Pediatrics.

20 Sep 2023

Researchers identify a rare cause of male infertility and discover a potential cure

Researchers investigated the genetic underpinning of asthenozoospermia, the leading cause of male fertility.

18 Sep 2023

Elite athletes bounce back strong: No long-term heart risks after COVID-19 recovery

The study finds that elite athletes who recovered from COVID-19 did not experience long-term negative effects on their cardiac health, allowing for the successful resumption of high-level sports. The findings also suggest that proper screening and medical counseling can pave the way for safe returns to sports post-COVID-19.

10 Sep 2023

Unlocking the genetic code of blood sugar reveals new diabetes risks and lung complications

The study used a genome-wide association study (GWAS) to analyze random glucose levels in nearly half a million non-diabetic subjects, uncovering 150 distinct genetic signals, including 53 new ones, linked to glycemic traits and type 2 diabetes. The research also discovered a causal effect of random glucose and type 2 diabetes on lung function, identifying lung dysfunction as a new diabetes complication.

10 Sep 2023

Study evaluating intranasal anti-CD3 for treatment of Alzheimer’s disease published in the PNAS journal

Tiziana Life Sciences Ltd. (“Tiziana” or the “Company”), a biotechnology company developing breakthrough immunomodulation therapies via novel routes of drug delivery, today announced acceptance of a publication, “Nasal Administration of anti-CD3 monoclonal antibody (mAb) ameliorates disease in a mouse model of Alzheimer’s disease”, in the preeminent journal, Proceedings of the National Academy of Sciences (PNAS), that supports foralumab’s mechanism as a potential treatment for Alzheimer’s disease (AD), a difficult-to-treat neuroinflammatory disease.

9 Sep 2023

IU study sheds new light on the genetic underpinnings of Alzheimer's disease

A groundbreaking study led by experts from Indiana University School of Medicine has shed new light on the genetic underpinnings of Alzheimer's disease.

6 Sep 2023

CN Bio and LifeNet Health LifeSciences partner to supply validated primary human cells for microphysiological systems

Partnership to provide customers with direct access to portfolio of highly characterized hepatic cells to recreate advanced Liver-on-a-Chip assays.

From CN-Bio 6 Sep 2023

Study investigates the pathophysiological mechanisms of PASC after COVID-19

Researchers investigated early pathophysiological mechanisms potentially underlying PASC post-SARS-CoV-2 infection.

4 Sep 2023

The first point-of-care genetic test for lactose intolerance: A compact, lab-on-phone diagnostic assay

The performance of a compact diagnostic assay that can accurately and rapidly diagnose lactose intolerance.

4 Sep 2023

Dectin-1 stimulation promotes pro-inflammatory response in HIV-positive individuals

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 16, entitled, "Dectin-1 stimulation promotes a distinct inflammatory signature in the setting of HIV-infection and aging."

31 Aug 2023

Phenotype News and Research

Study highlights the patient heterogeneity in atopic dermatitis and demonstrates the promises of personalized treatment

Trametinib: Potential therapeutic game-changer for Alzheimer's disease

Yeast in the gut linked to Crohn's disease inflammation, opening new doors for treatment

Arrayed CRISPR Screening for Revolutionizing Target Discovery

Is BMI the optimal adiposity marker to assess mortality risk?

Is presence of a premenstrual disorder associated with higher risk of early menopause and menopause-related vasomotor symptoms?

Newborn screening for neurodevelopmental disorders may cause more harm than good

Researchers identify a rare cause of male infertility and discover a potential cure

Elite athletes bounce back strong: No long-term heart risks after COVID-19 recovery

Unlocking the genetic code of blood sugar reveals new diabetes risks and lung complications

Study evaluating intranasal anti-CD3 for treatment of Alzheimer’s disease published in the PNAS journal

IU study sheds new light on the genetic underpinnings of Alzheimer's disease

CN Bio and LifeNet Health LifeSciences partner to supply validated primary human cells for microphysiological systems

Study investigates the pathophysiological mechanisms of PASC after COVID-19

The first point-of-care genetic test for lactose intolerance: A compact, lab-on-phone diagnostic assay

Dectin-1 stimulation promotes pro-inflammatory response in HIV-positive individuals

Exploring the role of the metabolic syndrome in individual mechanisms of liver fibrosis

Study finds semaglutide provides benefits for patients with obesity phenotype of heart failure and HFpEF

Innovative insights into effects of hematopoietic changes on colon cancer, unveiling therapeutic avenues

Beyond health records: Deep learning enhances disease diagnosis via image-based phenotyping

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

Latest News