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Neural circuits respond to rapid dopamine surges

Researchers assess the pharmacodynamics of dopamine signaling, brain connectivity/activity, and self-documented 'high' following methylphenidate exposure.v

14 Nov 2023

Optimal hydration post-exercise: Study compares sodium and carbohydrate levels in sports drinks for effective rehydration

In this study, researchers compared the effectiveness of sports drinks with varying carbohydrate and sodium levels for rehydrating athletes post-exercise, finding that drinks with higher sodium and lower carbohydrate content were more effective for rapid and complete rehydration. The study highlighted the importance of beverage composition in athlete recovery and hydration strategies.

13 Nov 2023

Recaticimab injection every 1-3 months may safely lower bad cholesterol

A new PCSK9 inhibitor (recaticimab) injected every one to three months may work safely and provide more flexible dosing to lower cholesterol, according to late-breaking science presented today at the American Heart Association's Scientific Sessions 2023.

13 Nov 2023

New drug zilebesiran effectively lowers blood pressure for six months, study finds

A single injection of the experimental medication zilebesiran was safe and effective in reducing systolic blood pressure in people with mild-to-moderate high blood pressure for up to six months, as detailed in the Phase 2 of the KARDIA study, reported as late-breaking science today at the American Heart Association's Scientific Sessions 2023.

13 Nov 2023

Single injection of new medication effectively eliminates Lp(a) for nearly one year

In the first human trial of a new therapeutic, a single injection of lepodisiran reduced levels of lipoprotein(a), or Lp(a), to undetectable levels for nearly one year, according to late-breaking science presented today at the American Heart Association's Scientific Sessions 2023.

13 Nov 2023

SELECT trial: Semaglutide reduces cardiovascular events by 20% in overweight or obese patients without diabetes

Findings from a multi-center, international clinical trial reported by a Cleveland Clinic physician show that semaglutide reduced cardiovascular events by 20% in adults with overweight or obesity and established cardiovascular disease who do not have diabetes.

13 Nov 2023

UK regulator approves a diabetes drug for weight management in obese and overweight patients

The Medicines and Healthcare products Regulatory Agency (MHRA) has today (8 November 2023) authorised via a national application route, a new indication for the diabetes medicine, Mounjaro (tirzepatide), for weight loss and weight management in adults aged 18 and over.

13 Nov 2023

Study suggests concomitant antidepressant and statin use could prevent treatment discontinuation

A recent study in the journal BMC Medicine evaluates the real-world impact of combining antidepressants with statins in UK adults, revealing lower discontinuation rates but similar efficacy compared to antidepressant-only treatment.

12 Nov 2023

Obinutuzumab shows promise in preserving kidney function, preventing flares in lupus nephritis patients

In a post hoc analysis of the phase 2 NOBILITY trial, researchers found that treatment with obinutuzumab-;an antibody that targets a protein expressed on certain immune cells-;was superior to placebo for preserving kidney function and preventing flares in patients with lupus nephritis, a kidney condition associated with the autoimmune disease lupus.

10 Nov 2023

Mucosal vaccine shows lasting defense against SARS-CoV-2 Omicron in primate study

In this groundbreaking study, researchers developed a mucosal adenoviral-vector vaccine, ChAd-SARS-CoV-2-S, which demonstrated sustained and robust immunity against a challenging Omicron variant in nonhuman primates, indicating a promising direction for durable COVID-19 protection strategies. Unlike traditional intramuscular vaccines, this mucosal vaccine elicited a comprehensive immune response, potentially paving the way for more effective and long-lasting COVID-19 vaccines.

9 Nov 2023

Patients with advanced HER2-positive breast cancer live longer if treated with pyrotinib, trial shows

Patients with HER2-positive breast cancer that has started to spread to other parts of the body survive for longer if they are treated with a new drug called pyrotinib, according to results from the longest follow-up of the PHOEBE randomized clinical trial in China.

8 Nov 2023

Which pharmacotherapies are associated with improved outcomes for people with alcohol use disorder?

Researchers assessed the efficacy and compared the relative effectiveness of various pharmacological treatments for alcohol use disorder.

8 Nov 2023

The effect of vegetarian diets on sports performance

The effects of vegetarian and omnivorous diets on athletic performance.

8 Nov 2023

Three new studies show low-dose atropine can help slow myopia in children

Myopia, or nearsightedness, is at an all-time high among children in the US. Globally, half the population is expected to be nearsighted by 2050.

6 Nov 2023

Study probes the hidden impact of low-cal sweeteners on gut health

The research scrutinizes the impact of low- and non-calorie sweeteners on gut microbiota, suggesting potential links to glucose tolerance and insulin resistance, with varying results across studies indicating a need for more comprehensive research.

5 Nov 2023

SSRIs show promise in easing post-COVID struggles, Dutch study reveals

Dutch study finds SSRIs significantly alleviate post-COVID syndrome symptoms, offering promising treatment avenues and shedding light on neurobiological mechanisms at play.

5 Nov 2023

How caffeine impacts cerebral blood flow

Caffeine consumption affects cerebral blood flow in young adults, with the study showing a dose-dependent reduction in arterial velocity post-intake. This impact on the cardiovascular system suggests caffeine's vasodilatory effects on cerebral arteries.

5 Nov 2023

Placebo News and Research

Neural circuits respond to rapid dopamine surges

Optimal hydration post-exercise: Study compares sodium and carbohydrate levels in sports drinks for effective rehydration

Recaticimab injection every 1-3 months may safely lower bad cholesterol

New drug zilebesiran effectively lowers blood pressure for six months, study finds

Single injection of new medication effectively eliminates Lp(a) for nearly one year

SELECT trial: Semaglutide reduces cardiovascular events by 20% in overweight or obese patients without diabetes

UK regulator approves a diabetes drug for weight management in obese and overweight patients

Study suggests concomitant antidepressant and statin use could prevent treatment discontinuation

Obinutuzumab shows promise in preserving kidney function, preventing flares in lupus nephritis patients

Mucosal vaccine shows lasting defense against SARS-CoV-2 Omicron in primate study

Patients with advanced HER2-positive breast cancer live longer if treated with pyrotinib, trial shows

Which pharmacotherapies are associated with improved outcomes for people with alcohol use disorder?

The effect of vegetarian diets on sports performance

Three new studies show low-dose atropine can help slow myopia in children

Study probes the hidden impact of low-cal sweeteners on gut health

SSRIs show promise in easing post-COVID struggles, Dutch study reveals

How caffeine impacts cerebral blood flow

Sotagliflozin provides kidney and heart benefits in patients with diabetes and chronic kidney disease

High-impact clinical trial results to be presented at ASN Kidney Week 2023

Study launched to test a vaginal film that slowly dissolves over the course of 30 days

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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