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SARS-CoV-2 inhibition mediated by cellular nucleic acid-binding protein

A recent study under review at Nature Portfolio and posted to the Research Square* preprint server depicted how cellular nucleic acid-binding protein (CNBP) inhibits severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

3 May 2022

CRISPR/Cas9 deletions induce adverse on-target genomic effects

Researchers utilized a CRISPR/Cas9 system to evaluate the usage of tRNA by deleting two tRNA genes from the genomes of hyper hepatocellular carcinoma and human near-haploid chronic myeloid leukemia cells.

27 Apr 2022

A novel mouse model to test SARS-CoV-2 viral infection

In a recent study posted to the Research Square* preprint server, researchers developed a novel mouse model for testing infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

26 Apr 2022

CRISPR-based detection of SARS-CoV-2 RNA directly from patient swabs

Researchers developed a clustered regularly interspaced short palindromic repeats-based diagnostic technique for detecting SARS-CoV-2 RNA.

21 Apr 2022

RNA interference triggers that target SARS-CoV-2 genome

Researchers screened ribonucleic acid interference against SARS-CoV-2.

18 Apr 2022

Delivery technologies of mRNA and pDNA for advanced therapeutic applications

Innovation Center of NanoMedicine (Center Director: Prof. Kazunori Kataoka) has announced that Prof. Satoshi Uchida (Principal Research Scientist), who is also Associated Professor of the Kyoto Prefectural University of Medicine, published an article review about non-viral messenger RNA (mRNA) and plasmid DNA (pDNA) delivery by addressing the various delivery technologies of mRNA and pDNA, from basic research to therapeutic and clinical application; Pharmaceutics 2022, 14(4), 810.

15 Apr 2022

Recent advances in non-viral nano-vector delivery of CRISPR/Cas9 genome editing payloads

Researchers reviewed non-viral nano-vectors used for delivering the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-mediated genome editing system.

14 Apr 2022

Nanocell COVID-19 vaccine elicits potent neutralizing response

A new study describes the high level of neutralizing antibodies elicited by a nanocell vaccine against SARS-CoV-2 in vitro, in vivo, and human studies.

11 Apr 2022

Researchers seek to understand how microbes in the GI tract help people resist pathogens

Published in Nature Communications, research from the University of Minnesota and Mayo Clinic sought to understand how microbial communities help people resist pathogens.

8 Apr 2022

Study detects SARS-CoV-2 BA.1/BA.2 recombinant in two epidemiologically linked cases

Researchers have focussed on detecting BA.1/BA.2 recombinant in travelers through surveillance.

5 Apr 2022

Research demonstrates potential of local siRNA delivery as COVID antiviral therapy in the lung

Scientists develop a formulation for the pulmonary administration of siRNA. The aim was to suppress the replication of SARS-CoV-2.

3 Apr 2022

Scientists explore impact of SARS-CoV-2 natural immunity on vaccine-induced immunity

A new study investigated the impact of pre-existing SARS-CoV-2 infection-induced immunity on vaccine-induced immunity.

31 Mar 2022

Minimal system for SARS-CoV-2 based virus-like particle production to study viral assembly and entry

Researchers proposed an optimal system to generate SARS-CoV-2 virus-like particles for examining viral assembly and entry into target host cells.

30 Mar 2022

Researchers create method to track SARS-CoV-2 RBD binding in vivo

Researchers developed a method for tracking the binding of the receptor-binding domain of SARS-CoV-2 in vivo using genetically engineered extracellular vesicles that can migrate to ACE2 expressing cells.

30 Mar 2022

Antiviral functions of interferon regulatory factors during human coronavirus infection

Researchers assessed the roles of the interferon regulatory factors: IRF1, IRF3, and IRF7 in infections by human coronaviruses.

30 Mar 2022

Preclinical investigation of intranasal adjuvanted COVID-19 vaccine

A new study reported systemic and mucosal immunity against SARS-CoV-2 via intranasal delivery of a vaccine containing recombinant SARS-CoV-2 antigens, nucleocapsid, and spike subunit.

30 Mar 2022

ProteoGenix launches new XtenCHOTM Transient CHO Expression System to improve biologics development

ProteoGenix, a contract research organization specialized in biologics discovery and bioproduction, announces the launch of its XtenCHOTM Transient Expression System.

From ProteoGenix 30 Mar 2022

Engineering rotavirus-based vaccine vectors expressing SARS-CoV-2 spike epitopes

Researchers proposed rotavirus-based vaccine vectors with the potential for developing polyvalent vaccines targeting multiple enteric viruses, including SARS-CoV-2.

30 Mar 2022

Using CRISPR/Cas to develop biosafety materials

Researchers discuss the use of the highly efficient CRISPR/Cas technologies to identify viral genome sequences for biosafety purposes.

21 Mar 2022

CRIPSR identifies cell-type-specific ACE2 modifiers

Researchers compile a list of candidate genes to identify the surface abundance of functional regulators of ACE2.

9 Mar 2022

Plasmid News and Research

SARS-CoV-2 inhibition mediated by cellular nucleic acid-binding protein

CRISPR/Cas9 deletions induce adverse on-target genomic effects

A novel mouse model to test SARS-CoV-2 viral infection

CRISPR-based detection of SARS-CoV-2 RNA directly from patient swabs

RNA interference triggers that target SARS-CoV-2 genome

Delivery technologies of mRNA and pDNA for advanced therapeutic applications

Recent advances in non-viral nano-vector delivery of CRISPR/Cas9 genome editing payloads

Nanocell COVID-19 vaccine elicits potent neutralizing response

Researchers seek to understand how microbes in the GI tract help people resist pathogens

Study detects SARS-CoV-2 BA.1/BA.2 recombinant in two epidemiologically linked cases

Research demonstrates potential of local siRNA delivery as COVID antiviral therapy in the lung

Scientists explore impact of SARS-CoV-2 natural immunity on vaccine-induced immunity

Minimal system for SARS-CoV-2 based virus-like particle production to study viral assembly and entry

Researchers create method to track SARS-CoV-2 RBD binding in vivo

Antiviral functions of interferon regulatory factors during human coronavirus infection

Preclinical investigation of intranasal adjuvanted COVID-19 vaccine

ProteoGenix launches new XtenCHOTM Transient CHO Expression System to improve biologics development

Engineering rotavirus-based vaccine vectors expressing SARS-CoV-2 spike epitopes

Using CRISPR/Cas to develop biosafety materials

CRIPSR identifies cell-type-specific ACE2 modifiers

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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