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Poliomyelitis (polio) is a highly infectious disease caused by a virus that invades the nervous system and can cause severe paralysis. The virus enters the body through the mouth and multiplies in the intestine. Initial symptoms are fever, fatigue, headache, vomiting, stiffness in the neck, and pain in the limbs. One in 200 infections leads to irreversible paralysis (usually in the legs). Among those paralyzed, 5-10% die when their breathing muscles become immobilized. Polio mainly affects children under five years of age. Naturally occurring polio was eliminated in the U.S. in 1979 and in the Western Hemisphere by 1991; however, worldwide efforts are continuing towards eradication of this contagious and devastating disease.
Cloned Zika virus could be used for development of attenuated vaccine

Cloned Zika virus could be used for development of attenuated vaccine

Stopping the explosive spread of Zika virus - which can lead to birth defects in babies born to infected mothers - depends on genetic insights gleaned through new tools and models. [More]
Many parents support HPV vaccine school-entry requirements with opt-out provisions

Many parents support HPV vaccine school-entry requirements with opt-out provisions

Requiring students to get vaccinated against the human papillomavirus, or HPV, to enter school could prevent many cancers linked to the virus, but University of North Carolina at Chapel Hill researchers found that many parents only support such requirements with opt-out provisions that could make the laws less effective. [More]
Nigerian Government reports 2 children paralyzed by wild poliovirus

Nigerian Government reports 2 children paralyzed by wild poliovirus

After more than two years without wild poliovirus in Nigeria, the Government reported today that 2 children have been paralyzed by the disease in the northern Borno state. [More]
Penn researchers develop plant-based oral vaccine booster

Penn researchers develop plant-based oral vaccine booster

Jonas Salk created a vaccine against polio that has been used since 1955; Albert Sabin created another version that has been on the market since 1961. Together, these two vaccines have nearly eliminated polio from the face of the earth. [More]
Scientists use Sure Chill technology to develop cost-effective vaccine storage

Scientists use Sure Chill technology to develop cost-effective vaccine storage

Vaccines against killer diseases from polio to hepatitis are fragile and can easily be made useless if they get too hot or too cold. [More]
Health strategies for families when traveling abroad with kids

Health strategies for families when traveling abroad with kids

Before your family heads to Mexico, Asia or beyond this summer, do a little planning to keep everyone healthy during their journey. Dr. Nava Yeganeh, an assistant professor of pediatric infectious diseases and director of the Pediatric International Travel and Adoption Clinic at Mattel Children's Hospital UCLA, explains three important strategies. [More]
Clinical trial to test safety, efficacy of Roswell Park-developed SurVaxM in multiple myeloma patients

Clinical trial to test safety, efficacy of Roswell Park-developed SurVaxM in multiple myeloma patients

An immune-based therapy developed at Roswell Park Cancer Institute is moving forward with its third clinical trial. The early-stage clinical trial will assess whether SurVaxM — a cancer vaccine developed at Roswell Park — is a safe and effective treatment option for patients with multiple myeloma, a rare type of blood cancer. [More]
Injectable IPV with bivalent oral vaccine safer than using oral vaccine alone

Injectable IPV with bivalent oral vaccine safer than using oral vaccine alone

A groundbreaking study released today shows that a single injectable dose of inactivated polio vaccine (IPV) along with bivalent oral polio vaccine could protect up to 90 percent of children from polio and strengthen community protection against the disease. [More]
Fluorescent proteins help trace viral infections

Fluorescent proteins help trace viral infections

Researchers at Umea University have developed a new method to directly follow viral infections in living organisms. This method can make infected cells produce fluorescent proteins, which means that they light up and become easier to identify. [More]
Doctor’s access to vaccination data can improve pediatric immunization coverage

Doctor’s access to vaccination data can improve pediatric immunization coverage

Exchange of immunization data between a centralized city immunization registry and provider electronic health records led to significant improvements in pediatric immunization coverage, a reduction in over-immunization for adolescents, and increased completeness of immunization records, according to a study conducted at Columbia University's Mailman School of Public Health, Columbia University Medical Center, NewYork-Presbyterian, and the New York City Department of Health and Mental Hygiene's Citywide Immunization Registry. [More]
First-ever vaccine to combat Leishmaniasis under development

First-ever vaccine to combat Leishmaniasis under development

As scientists scramble to get a Zika virus vaccine into human trials by the end of the summer, a team of researchers is working on the first-ever vaccine to prevent another insect-borne disease - Leishmaniasis - from gaining a similar foothold in the Americas. [More]
WHO outlines steps to close immunization gap across countries during World Immunization Week 2016

WHO outlines steps to close immunization gap across countries during World Immunization Week 2016

During World Immunization Week 2016, held 24-30 April, the World Health Organization highlights recent gains in immunization coverage, and outlines further steps countries can take to “Close the Immunization Gap” and meet global vaccination targets by 2020. [More]
Abstracts on colistin resistance and migrant health part of 300 late-breaker sessions for ECCMID 2016

Abstracts on colistin resistance and migrant health part of 300 late-breaker sessions for ECCMID 2016

The European Society of Clinical Microbiology and Infectious Disease (ESCMID) – an organization that explores risks, knowledge sharing and best practices in the fight against infectious disease – has received more than 300 late-breaker abstract submissions for its annual congress, ECCMID 2016 in Amsterdam. [More]
Scientists identify two enzymes that appear to play role in metabolism, inflammation

Scientists identify two enzymes that appear to play role in metabolism, inflammation

A team led by scientists at The Scripps Research Institute and the Salk Institute for Biological Studies has discovered two enzymes that appear to play a role in metabolism and inflammation—and might someday be targeted with drugs to treat type 2 diabetes and inflammatory disorders. [More]
Global climate crisis threatens public health

Global climate crisis threatens public health

In a review published in the Annals of Global Health, doctors warn of the impending public health crisis brought on by climate change and call for action to help prepare the world for what is ahead. [More]
Poll: 59% of parents rate flu vaccine less favorably than other childhood vaccines

Poll: 59% of parents rate flu vaccine less favorably than other childhood vaccines

Parents who do not get their children flu shots rate the flu vaccine less favorably than other childhood vaccines, a national poll finds. [More]
Leeds scientists to start computer drug research to find cure for Ebola virus

Leeds scientists to start computer drug research to find cure for Ebola virus

Scientists at the University of Leeds will run the equivalent of password cracking software to find the chemical keys to defeating the Ebola virus. [More]
Duchenne muscular dystrophy: direct effect on muscle stem cells? An interview with Dr Rudnicki

Duchenne muscular dystrophy: direct effect on muscle stem cells? An interview with Dr Rudnicki

For twenty years, it has been understood that dystrophin is expressed in differentiated muscle fibers where it is part of a protein complex that crosses the membrane and connects the extracellular matrix to the actin network inside the cell to provide structural integrity. [More]
Antivirulence antibiotics could evade resistance longer than traditional antibiotics

Antivirulence antibiotics could evade resistance longer than traditional antibiotics

We've all seen the headlines. "Man found to be shedding virulent strain of polio"; "Virulent flu strain in Europe hits the economy"; "Most virulent strain of E. coli ever seen contains DNA sequences from plague bacteria." [More]
Gene linked to autism lays groundwork for crucial brain structure during prenatal development

Gene linked to autism lays groundwork for crucial brain structure during prenatal development

A gene linked to mental disorders helps lays the foundation for a crucial brain structure during prenatal development, according to Salk Institute research published January 14, 2016 in Cell Reports. [More]
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