Polymerase News and Research

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DinB DNA polymerase is a key player in DNA repair

A quarter century after they discovered it, researchers have identified the job of one of the most common DNA-damage response proteins. The enzyme has puzzled scientists because it is present in nearly every organism, which suggests that it is crucial to life, and yet, in laboratory experiments, its function has remained a mystery.

11 Jan 2006

DNA polymerase zeta gives cells with damaged DNA a new lease on life

Fortunately, our cells contain many enzymes devoted strictly to detecting and repairing any damage caused by these insults. In fact, failure of these enzymes to make needed repairs to genes can lead to the accumulation of mutations and, eventually, cell death or possibly cancer.

6 Jan 2006

New findings on bacterial vaginosis

Despite being one of the most common infections among women, scientists and doctors know little about the causes of bacterial vaginosis (BV), a usually benign disease that is also linked to serious health problems including pelvic inflammatory disease

3 Nov 2005

New insights into how genetic mutations arise

Researchers at Stanford University have created a larger-than-normal DNA molecule that is copied almost as efficiently as natural DNA.

27 Oct 2005

New whooping cough vaccine for adolescents and adults

In the first study of its kind, researchers at Saint Louis University have demonstrated that immunization with a new vaccine could potentially prevent more than a million cases of pertussis (whooping cough) each year in adolescents and adults.

24 Oct 2005

Spliceosome crucial for processing non-coding RNA

The discovery in 1977 that the coding regions of a gene could appear in separate segments along the DNA won the 1993 Nobel Prize in Physiology or Medicine for Richard J. Roberts and Phillip A. Sharp. The active segments of a gene were termed exons, separated from each other within the gene by inactive introns.

20 Oct 2005

First time a protein serving as a template for DNA synthesis seen

Since the discovery of the structure of DNA by James Watson and Francis Crick in 1953, the paradigm for DNA replication has stated that the DNA itself codes for the appropriate pairings for replication.

3 Oct 2005

Equine flu virus jumps to dogs

A Cornell University virologist has isolated a highly contagious equine flu virus that is spreading a sometimes-fatal respiratory flu among dogs, and is responsible for a major dog-flu outbreak in New York state. There is no evidence that the virus could infect people.

27 Sep 2005

Pursuit of potential drugs and small molecules that target the IGF-1 receptor

Pharmaceutical companies around the world still come knocking on Renato Baserga, M.D.,'s door. And for good reason.

27 Sep 2005

How some antibiotics kill bacteria

Researchers have uncovered how members of one family of antibiotics kill bacteria that make people sick.

11 Aug 2005

Genelabs drug discovery team advances compounds against the hepatitis C virus

Genelabs Technologies today announced that a non-nucleoside compound from its internal Hepatitis C virus (HCV) drug discovery program has advanced into preclinical development.

4 Aug 2005

Changes to prenatal genetic testing could mean more babies born with abnornalities

A study in the UK suggests that a proposed change to the type of prenatal genetic testing offered to couples in the UK, could possibly result in certain chromosome abnormalities being missed.

4 Jul 2005

Birth abnormality rates could increase if proposed changes to prenatal testing go ahead

A proposed change to the type of prenatal genetic testing offered to couples in the UK could result in certain chromosome abnormalities being missed, suggests a study published online today (Thursday June 30, 2005) by The Lancet.

1 Jul 2005

Inactive gene may explain higher incidence of prostate cancer in African-Americans compared to Caucasians

Among African-Americans with prostate cancer, a tumor-suppressing gene called GSTP1 is inactivated at a rate 3.5 times higher than among Caucasians, according to a study conducted at the San Francisco VA Medical Center (SFVAMC).

16 Jun 2005

Tonsil swabbing is terrible - it makes people gag

Mayo Clinic ear, nose and throat surgeons hoped to find a more user-friendly test for strep throat than swabbing the tonsils directly, but instead discovered that the swab has to touch the tonsils to accurately detect the infection.

15 May 2005

A simple spit test could predict cancers

In future scientists say, a test as simple as spitting into a collection tube or cup might be a screening test for breast cancer and the early detection of other tumours.

19 Apr 2005

Alarming trends in sexually transmitted diseases (STDs) among America's young people

A study by ASHA, sponsored by Roche Diagnostics of Indianapolis, Indiana is being released in conjunction with April's STD Awareness Month and demonstrates that the incident rate of STDS in youth (ages 15-24) have increased dramatically in recent years.

12 Apr 2005

CDC experts sent to Angola to help with Marburg epidemic

In an effort to control the Marburg virus outbreak in Angola, Health officials from the Centers for Disease Control and Prevention in Atlanta will assist the World Health Organization by going to Angola to help with outbreak investigation, infection control and laboratory diagnosis of the disease.

30 Mar 2005

DNA sequencing made portable and faster by "colour-blind" technology

Researchers at Baylor College of Medicine (BCM) and Rice University have developed a"colour-blind" method of fluorescence detection which could open new doors that would take DNA sequencing to the patient's bedside, the doctor's office and even the scene of a crime or a battlefield.

29 Mar 2005

Test that will prevent the needless loss of the thyroid gland in people with the noncancerous condition

New research suggests that physicians can distinguish between a type of thyroid cancer and an identical-looking, non-cancerous thyroid condition by simply determining the activity of three genes.

28 Mar 2005