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Phase 3 trial: NEXAVAR tablets fail to meet primary endpoint in HER2-negative breast cancer patients

Phase 3 trial: NEXAVAR tablets fail to meet primary endpoint in HER2-negative breast cancer patients

Bayer HealthCare and Onyx Pharmaceuticals Inc., an Amgen subsidiary, today announced that an investigational Phase 3 trial of NEXAVAR (sorafenib) tablets in patients with advanced breast cancer did not meet its primary endpoint of improving progression-free survival (PFS). [More]
Potassium supplements with loop diuretics increase survival rates of heart failure patients

Potassium supplements with loop diuretics increase survival rates of heart failure patients

Researchers from the Perelman School of Medicine at the University of Pennsylvania found that patients taking prescription potassium supplements together with loop diuretics for heart failure have better survival rates than patients taking diuretics without the potassium. Moreover, the degree of benefit increases with higher diuretic doses. [More]
Study of cancer radiation therapy shows that DNA building blocks are susceptible to fragmentation

Study of cancer radiation therapy shows that DNA building blocks are susceptible to fragmentation

A new study relevant for cancer radiation therapy shows that DNA building blocks are susceptible to fragmentation. Scientists now have a better understanding of how short DNA strands decompose in microseconds [More]
Healthy lifestyle helps hard-to-treat hypertensive patients

Healthy lifestyle helps hard-to-treat hypertensive patients

Maintaining a healthy lifestyle can prevent cardiovascular events even among patients with apparent treatment-resistant hypertension, say researchers. [More]
Dyadic International announces details regarding new Bakenzyme project

Dyadic International announces details regarding new Bakenzyme project

Dyadic International, Inc. ("Dyadic") (OTCQX: DYAI), a global biotechnology company focused on the discovery, development, manufacture and sale of enzymes and other proteins for the bioenergy, bio-based chemicals, biopharmaceutical, food and feed industries, announced today details regarding its new Bakenzyme project. [More]
Study uncovers new information on genes that may increase risk of cardiac arrhythmias

Study uncovers new information on genes that may increase risk of cardiac arrhythmias

Two international research studies, both led by investigators affiliated with Massachusetts General Hospital (MGH) and the Broad Institute of MIT and Harvard, have uncovered new information about genes that may increase the risk of serious cardiac arrhythmias. [More]
Dosing commences in Essentialis’ DCCR clinical study in obese Prader-Willi syndrome patients

Dosing commences in Essentialis’ DCCR clinical study in obese Prader-Willi syndrome patients

Essentialis announced today the dosing of the first patient in clinical study PC025, which is designed to evaluate the safety and efficacy of diazoxide choline controlled release tablets (DCCR) in obese Prader-Willi syndrome patients. [More]
Study calls for improvements in physicians' inconsistent record of ordering lab tests

Study calls for improvements in physicians' inconsistent record of ordering lab tests

Why does one physician in a walk-in practice order laboratory monitoring tests for patients more often than a colleague working down the hallway? [More]
Required dose of saline solutions can prevent common injuries in football players

Required dose of saline solutions can prevent common injuries in football players

Some of the most common injuries in football players are violent joint sprains and muscle strains in the legs, which are sometimes caused by anxiety and fatigue accumulated after several games in a few weeks. [More]
Researchers discover analgesic mechanism that prevents pain in Buruli ulcer patients

Researchers discover analgesic mechanism that prevents pain in Buruli ulcer patients

When the body receives an injury to the skin, a signal is sent to the brain, which generates a sensation of pain. [More]
Study: Women who are overweight have faulty switch

Study: Women who are overweight have faulty switch

Crucially, the discovery, published today in the journal Nature Communications, shows that women who are overweight have a faulty switch. [More]
Hypertension medication may cause metabolic-related adverse events in older adults

Hypertension medication may cause metabolic-related adverse events in older adults

Adults over 65 who have recently begun thiazide diuretics are at a greater risk for developing metabolic-related adverse events, researchers at UT-Southwestern Medical Center have found. [More]
Grain legume crops overlooked as potentially valuable sources of micronutrients

Grain legume crops overlooked as potentially valuable sources of micronutrients

Popular diets across the world typically focus on the right balance of essential components like protein, fat, and carbohydrates. These items are called macronutrients, and we consume them in relatively large quantities. [More]
Painless wearable microneedle device can analyze electrolyte levels on the spot

Painless wearable microneedle device can analyze electrolyte levels on the spot

Patients trying to navigate today's complex medical system with its costly laboratory analyses might prefer a pain-free home diagnostic device, worn on the wrist, that can analyze, continuously record and immediately remedy low electrolyte levels. [More]
Parents should take initiative to make sure their hungry teens have healthy fare to eat

Parents should take initiative to make sure their hungry teens have healthy fare to eat

Refrigerators and pantries across the country are bracing for the seasonal assault from teenagers who are now done with school and will eat most of their meals at home for the summer months. [More]
Autifony Therapeutics awarded £2.2 million to progress first-in-class drug for tinnitus into Phase IIa study

Autifony Therapeutics awarded £2.2 million to progress first-in-class drug for tinnitus into Phase IIa study

Autifony Therapeutics Limited (“Autifony”), which is pioneering the development of novel pharmaceutical treatments for hearing disorders, today announced that it has been awarded funding of £2.2 million towards a Phase IIa clinical trial in tinnitus patients with its lead compound AUT00063, by the UK’s innovation agency, the Technology Strategy Board. [More]
Transplantation of embryonic neural cells can alleviate epilepsy seizure activity in mice

Transplantation of embryonic neural cells can alleviate epilepsy seizure activity in mice

New research from North Carolina State University pinpoints the areas of the cerebral cortex that are affected in mice with absence epilepsy and shows that transplanting embryonic neural cells into these areas can alleviate symptoms of the disease by reducing seizure activity. [More]
Researchers identify heart-specific form of protein that protects against irregular heartbeats

Researchers identify heart-specific form of protein that protects against irregular heartbeats

Researchers at the Cedars-Sinai Heart Institute have identified a heart-specific form of a protein, BIN1, responsible for sculpting tiny folds in pockets that are present on the surface of heart muscle cells. [More]
Research may offer unique pathway for targeting new therapeutics for addiction treatment

Research may offer unique pathway for targeting new therapeutics for addiction treatment

A research team from the Friedman Brain Institute of the Icahn School of Medicine at Mount Sinai has published evidence that shows that subtle changes of inhibitory signaling in the reward pathway can change how animals respond to drugs such as cocaine. [More]
Salix Pharmaceuticals' total net product revenue increases 90% to $384.4 million in Q1 2014

Salix Pharmaceuticals' total net product revenue increases 90% to $384.4 million in Q1 2014

Salix Pharmaceuticals, Ltd. today announced financial and operating results for the first quarter ended March 31, 2014, and other business updates. [More]