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Ludwig scientists deconstruct the blood supply of brain metastases

A Ludwig Cancer Research study has generated a granular portrait of how the cellular and molecular components of the blood vessels that feed brain metastases of melanoma and lung and breast cancers differ from those of healthy brain tissue, illuminating how they help shape the internal environment of tumors to support cancer growth and immune evasion.

19 Jan 2024

Insilico Medicine leverages AI to identify promising new target for breast and gynecological cancers

Insilico Medicine("Insilico"), a clinical stage generative artificial intelligence (AI)-driven drug discovery company, recently published an early research that it has identified MYT1 as a promising new therapeutic target for breast and gynecological cancer, and discovered a series of novel, potent, and highly selective inhibitors specifically targeting MYT1.

19 Jan 2024

New study reveals flaws in AI tools used for SARS-CoV-2 antibody discovery

A discovery program for SARS-CoV-2-nABs potentially targeting its resistant strains.

19 Jan 2024

Researchers make new breakthrough in better understanding the immune system to fight diseases

The Xue Lab at the Hackensack Meridian Center for Discovery and Innovation (CDI) has made another breakthrough in better understanding, and potentially modulating, the immune system to fight diseases.

18 Jan 2024

New structural insights pave the way for drug-resistant malaria therapies

Structural insights into a potent antimalarial drug candidate's interaction with the malaria parasite Plasmodium falciparum have paved the way for drug-resistant malaria therapies, according to a new study by researchers at Weill Cornell Medicine and Van Andel Institute.

18 Jan 2024

Uncovering the cellular roots of spinocerebellar ataxia type 6

Researchers from McGill University, led by Professor Alanna Watt of the Department of Biology, have identified previously unknown changes in brain cells affected by a neurological disease.

18 Jan 2024

Children battling meningitis face lifelong disability, study finds

One in three children who suffer from bacterial meningitis live with permanent neurological disabilities due to the infection.

18 Jan 2024

Mathematical modeling demonstrates efficacy of combinational drug therapy for breast cancer treatment

Researchers use a mathematical model to assess the efficacy of a new combinational therapy of AZD9496 and palbociclib for breast cancer treatment.

18 Jan 2024

Anti-HIV drugs can be used to prevent inflammatory complications of bacterial sepsis

Bacterial infections can lead to the formation of abscesses -; pockets of dead cells and debris surrounded by inflammatory immune cells. Bacteria multiply within abscesses, causing more inflammation and further damage to surrounding tissues.

17 Jan 2024

Study highlights a potential new strategy to target triple-negative breast cancer

Cleveland Clinic researchers have successfully developed a therapeutic peptide that blocks aggressive cancer cells from multiplying rapidly.

17 Jan 2024

Study suggests gut phages may be involved in the development of asthma

Researchers investigated the relationship between early-life gut virome, specifically temperate phage taxa, and the development of asthma in childhood while considering the interaction with host genetics and the bacteriome.

17 Jan 2024

StemSight and ERS Genomics focus on collaboration

License agreement provides StemSight access to CRISPR/Cas9 technology to be applied in development of cell therapies for corneal blindness.

17 Jan 2024

Spider venom molecule meets benchmarks to treat heart attack and stroke

A spider venom molecule being investigated by a University of Queensland team has met critical benchmarks towards becoming a treatment for heart attack and stroke.

16 Jan 2024

Vanderbilt launches $13 million trial to test repurposed drugs for Rett syndrome

Vanderbilt University Medical Center received a $13 million Department of Defense grant to lead a multisite clinical trial that will evaluate repurposed FDA-approved drugs as treatment options for patients with Rett syndrome.

16 Jan 2024

Why S. aureus vaccines fail: Immune system hijacked by sneaky bacteria

Staphylococcus aureus (SA) is an extremely common bacterial infection; about 30% of people have colonies of SA living in their nose.

16 Jan 2024

Study explores intratumoral microbiota as a novel frontier in cancer research

Researchers review the role of intratumoral microbiota in cancer development, suggesting its potential in predicting and treating various cancers.

14 Jan 2024

FDA-approved drug may help to decrease pain after surgery, study finds

Researchers in the Department of Anesthesia and Perioperative Medicine at the Medical University of South Carolina (MUSC) have found that an FDA-approved drug may help to decrease pain after surgery.

12 Jan 2024

3D nanomatrix vascular sheet model for high-throughput atherosclerosis drug testing

A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, University of Alabama at Birmingham researchers report in the journal Biomaterials.

12 Jan 2024

New approach using ultrasound-guided drug delivery effectively targets lymph node metastasis

Researchers at Tohoku University have discovered a new approach for treating lymph node metastasis. Anticancer drugs are administered directly into the LNs under ultrasound guidance (Lymphatic Drug Delivery System or LDDS) to target sentinel lymph nodes (LNs) and generate antitumor effects locally, preventing distant metastasis.

12 Jan 2024

When mass spectrometry redefines the pharma industry

In this new episode of omg OMx, Kate Stumpo speaks to Bruker's Mike Greig about the incredible potential of mass spectrometry in pharma.

From Bruker Life Sciences Mass Spectrometry 12 Jan 2024

Preclinical News and Research

Ludwig scientists deconstruct the blood supply of brain metastases

Insilico Medicine leverages AI to identify promising new target for breast and gynecological cancers

New study reveals flaws in AI tools used for SARS-CoV-2 antibody discovery

Researchers make new breakthrough in better understanding the immune system to fight diseases

New structural insights pave the way for drug-resistant malaria therapies

Uncovering the cellular roots of spinocerebellar ataxia type 6

Children battling meningitis face lifelong disability, study finds

Mathematical modeling demonstrates efficacy of combinational drug therapy for breast cancer treatment

Anti-HIV drugs can be used to prevent inflammatory complications of bacterial sepsis

Study highlights a potential new strategy to target triple-negative breast cancer

Study suggests gut phages may be involved in the development of asthma

StemSight and ERS Genomics focus on collaboration

Spider venom molecule meets benchmarks to treat heart attack and stroke

Vanderbilt launches $13 million trial to test repurposed drugs for Rett syndrome

Why S. aureus vaccines fail: Immune system hijacked by sneaky bacteria

Study explores intratumoral microbiota as a novel frontier in cancer research

FDA-approved drug may help to decrease pain after surgery, study finds

3D nanomatrix vascular sheet model for high-throughput atherosclerosis drug testing

New approach using ultrasound-guided drug delivery effectively targets lymph node metastasis

When mass spectrometry redefines the pharma industry

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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