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Researchers find a switch to regulate the diabetes-causing gene

Researchers at the Centre for Genomic Regulation and Imperial College London have found a switch that regulates the activity of a gene that causes diabetes.

27 Oct 2022

Variations in low-complexity regions in monkeypox genome found to impact virus transmissibility

In a new study, researchers investigated whether low-complexity regions (LCRs) were more accountable for the current 2022 IIb clade monkeypox (MPX) virus (MPXV) outbreak rather than single-nucleotide polymorphisms (SNPs).

24 Oct 2022

Scientists develop a pseudovirus system to deep mutational scan the full SARS-CoV-2 spike

A pseudovirus system based on deep mutational scanning determines how SARS-CoV-2 mutations can affect its ability to escape neutralization.

18 Oct 2022

Study finds telomeres can set damage thresholds for cancer cells above which they cannot continue to divide

A recent study hypothesized that ALT might compromise telomere integrity if not restricted appropriately.

21 Sep 2022

Researchers demonstrate improved culture of primate induced pluripotent stem cells

The following study transplanted iPSCs derived from two NHP species, chimpanzee and pigtailed macaque, into blastocysts from another NHP species – the rhesus macaque.

1 Sep 2022

How can we map the human genetic architecture of COVID-19 across all ancestry groups?

In a new study, researchers formed the COVID-19 host genetics initiative to compile a genome-wide association meta-analysis of 60 studies from 25 countries.

8 Aug 2022

Researchers assess UK biobank genome sequences

In a new study, researchers analyzed 150,119 genome sequences from the United Kingdom Biobank (UKB).

26 Jul 2022

A VSV-based COVID vaccine effective against SARS-CoV-2 variants

A new study discusses the development of recombinant vesicular stomatitis virus COVID-19 vaccines.

25 Jul 2022

Tissue nanotransfection technology can serve as a non-viral, topical, gene-editing delivery device, research shows

The Indiana Center for Regenerative Medicine and Engineering (ICRME) at Indiana University School of Medicine is home to tissue nanotransfection (TNT) regenerative medicine technology that achieves functional tissue reprogramming in the live body.

19 Jul 2022

Rice researchers use deactivated Cas9 proteins to synthetically trigger the transcription of genes

Rice University researchers have demonstrated that CRISPR-Cas9, increasingly famous as a gene-editing tool, can be employed in powerful additional ways in human cells.

18 Jul 2022

Disrupting genes in the yeast Pichia pastori to increase its secretory production of useful proteins

A collaboration including researchers from Kobe University, University of Tokyo and Tohoku University has successfully identified and disrupted genes in the yeast Pichia pastoris (1) in order to increase its secretory production of useful proteins (2).

8 Jul 2022

How does obesity affect the immune system?

A new study summarizes new findings on the immunoregulatory effects of excessive fat stores or malnutrition through Th2 cells.

4 Jul 2022

The identification and characterization of a thermophilic Cas13a ortholog highly active at the temperatures required for RT-LAMP

Researchers developed a new detection assay for SARS-CoV-2.

1 Jul 2022

Researchers map cancer driver mutations across the human genome

In a recent study published in Nature Biotechnology, researchers explored the causes of cancer by mapping somatic mutation rates across the human genome.

22 Jun 2022

Scientists characterize type I IFN response during SARS-CoV-2 infection

In a recent study posted to the bioRxiv* preprint server, Canadian researchers assessed the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on interferon (IFN) response.

15 Jun 2022

The potential mechanisms of SARS-CoV-2 to induce DNA damage

Researchers described potential mechanisms of coronaviruses that could lead to DNA damage and the potential link between SARS-CoV-2 activity and such mechanisms.

14 Jun 2022

New fluorogenic probe could quickly detect the presence of influenza A virus

The influenza A virus, which is responsible for seasonal flu outbreaks, is also the only influenza virus that has previously caused flu pandemics.

6 Jun 2022

The link between androgens and COVID-19

A new paper examines the association between androgens and COVID-19, as revealed by the research carried out on this topic throughout the pandemic.

20 May 2022

Study identifies cancer biomarkers based on a type of genetic modification

Biomarkers are often used during the management of cancer to guide treatment decisions and predict patient outcomes. However, it is often difficult to identify appropriate biomarkers that can be consistently reproduced and are easily analyzed with limited patient specimens.

18 May 2022

Camelid IFNs could play important role in combating emerging zoonotic pathogens

In a recent study published in the Developmental & Comparative Immunology journal, the discovery of a novel form of mammalian interferon-Beta (IFN-β) with four cysteine residues from the dromedary camel and the five remaining members of the mammalian suborder Tylopoda is described.

17 May 2022