Prophylaxis News and Research

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Study identifies ultra-broad SARS-CoV-2 neutralizing antibodies that target various spike epitopes

Researchers screened the circulating B lymphocyte repertoires of coronavirus disease 2019 convalescents and vaccines using multiplexed antigen panels.

3 Apr 2023

Monthly prophylactic fitusiran injections effective in reducing bleeds in patients with hemophilia A or B

Monthly prophylactic injections of fitusiran are effective in reducing bleeds in patients with hemophilia A or B, according to randomized controlled trials publishing simultaneously in The Lancet and The Lancet Haematology journals.

30 Mar 2023

The decision-making process for the launch of trials for COVID-19 repurposed antivirals

Researchers reviewed the decision-making process for performing randomized clinical trials for three drugs under consideration for repurposing for COVID-19 treatment: remdesivir, molnupiravir, and tenofovir disoproxil fumarate.

30 Mar 2023

New study suggests broad neutralizing antibody could provide three years of COVID protection

In a recent article published in the journal Science Translational Medicine, researchers showed that a novel, lab-engineered monoclonal antibody (mAb), adintrevimab conferred up to 50% protection against symptomatic coronavirus disease 2019 (COVID-19). Furthermore, it demonstrated this exceptional efficacy in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–naïve individuals even at titers as low as 1:30.

27 Mar 2023

International trade of colistin in animal feed continues unabated

Researchers investigate Enterobacterales species resistance to colistin in Pakistan.

22 Mar 2023

New antimalarial prevents malaria more effectively than current treatments but does not improve birth outcomes

A large LSTM-led trial confirms new antimalarial, dihydroartemisinin-piperaquine, is more effective at preventing malaria than current WHO recommended treatment but does not improve adverse birth outcomes.

10 Mar 2023

A small protein could provide a revolutionary approach to tackling obesity-related diseases

Research published today shows that a peptide (small protein) called PEPITEM could provide a revolutionary approach to reducing the risk of type 2 diabetes and other obesity-related diseases such as hepatic steatosis (fatty liver).

9 Mar 2023

Study examines parental concerns of their sexual and gender minority adolescents using PrEP

Since its approval in 2012, HIV pre-exposure prophylaxis, or PrEP, has shown promise in reducing HIV infection rates by preventing infection in high-risk HIV-negative people.

2 Mar 2023

Use of dapivirine vaginal ring during third trimester of pregnancy poses no safety concerns

A vaginal ring containing the antiretroviral drug dapivirine posed no safety concerns when used in the third trimester of pregnancy, according to results to date from the first study of the dapivirine ring during pregnancy and one of only a few studies of an HIV prevention product in pregnant cisgender women.

20 Feb 2023

Doxycycline taken after sex does not prevent bacterial STIs among cisgender women

Researchers from the University of Washington (UW), Kenya Medical Research Institute (KEMRI), and Hennepin Healthcare Research Institute (HHRI) announced results at CROI from a clinical trial demonstrating that doxycycline taken after sex does not prevent bacterial sexually transmitted infections (STIs) – chlamydia or gonorrhea – among cisgender women.

20 Feb 2023

HIV prevention model in Zambian prisons may be extended to other criminal justice facilities

A recent study performed in Zambia by University of Maryland School of Medicine's Institute of Human Virology researchers found that high uptake of HIV preventative medicine, known as pre-exposure prophylaxis (PrEP), is possible in prison populations with adequate resources and support from the criminal justice health system.

16 Feb 2023

Single dose of the antibiotic azithromycin decreases sepsis and death risk during childbirth

A single dose of the antibiotic azithromycin can help protect mothers from dangerous sepsis infections and death during vaginal childbirth, a sweeping new international study from a UVA Health scientist and his collaborators has found.

9 Feb 2023

New formulation can provide up to six months of full protection against HIV

For people at high risk of contracting HIV, missing doses of their daily HIV prevention pills can have big consequences. In some cases, missing a pill can lead to lack of protection against the virus.

9 Feb 2023

New milestones for the treatment of hemophilia

Hemophilia A is the most common severe form of hemophilia. It affects almost exclusively the male sex. The disease can usually be treated well, but the medicines known so far do not help all of those affected.

9 Feb 2023

Side-effects and costs are important issues for users of HIV pre-exposure prophylaxis, survey finds

A new survey finds that men who would be potential users of HIV pre-exposure prophylaxis (PrEP) medication prefer long-acting injections over pills, but rank side effects and costs as the most important issues for them in considering whether to take PrEP.

1 Feb 2023

A slight increase in Mpox cases across the globe, along with an increase in deaths

The WHO discusses genomic sequencing of the Mpox virus, in addition to providing public and clinical health links between HIV and Mpox.

24 Jan 2023

WHO’s 14th situation report for the multi-country outbreak of mpox overviews the clinical and public health links between HIV and mpox

In the present report, researchers reported the most recent findings of MPXV infections.

23 Jan 2023

How do mutations in emergent SARS-CoV-2 Omicron variants affect viral function, human immunity, and recognition by therapeutic antibodies?

Researchers explored how mutations in emergent SARS-CoV-2 variants affect viral function, human immunity, and recognition by therapeutic antibodies.

19 Jan 2023

Investigational vaccine regimen safe but did not provide protection against HIV acquisition

An investigational HIV vaccine regimen tested among men who have sex with men (MSM) and transgender people was safe but did not provide protection against HIV acquisition, an independent data and safety monitoring board (DSMB) has determined.

18 Jan 2023

Researchers report that vectored expression of a high-affinity ACE2 microbody protein establishes a high degree of protection from SARS-CoV-2

Researchers evaluated the use of receptor decoys for SARS-CoV-2 based on soluble forms of ACE2 for immunological prophylaxis and management of COVID-19 through the use of AAV vectors.

16 Jan 2023

Prophylaxis News and Research

Study identifies ultra-broad SARS-CoV-2 neutralizing antibodies that target various spike epitopes

Monthly prophylactic fitusiran injections effective in reducing bleeds in patients with hemophilia A or B

The decision-making process for the launch of trials for COVID-19 repurposed antivirals

New study suggests broad neutralizing antibody could provide three years of COVID protection

International trade of colistin in animal feed continues unabated

New antimalarial prevents malaria more effectively than current treatments but does not improve birth outcomes

A small protein could provide a revolutionary approach to tackling obesity-related diseases

Study examines parental concerns of their sexual and gender minority adolescents using PrEP

Use of dapivirine vaginal ring during third trimester of pregnancy poses no safety concerns

Doxycycline taken after sex does not prevent bacterial STIs among cisgender women

HIV prevention model in Zambian prisons may be extended to other criminal justice facilities

Single dose of the antibiotic azithromycin decreases sepsis and death risk during childbirth

New formulation can provide up to six months of full protection against HIV

New milestones for the treatment of hemophilia

Side-effects and costs are important issues for users of HIV pre-exposure prophylaxis, survey finds

A slight increase in Mpox cases across the globe, along with an increase in deaths

WHO’s 14th situation report for the multi-country outbreak of mpox overviews the clinical and public health links between HIV and mpox

How do mutations in emergent SARS-CoV-2 Omicron variants affect viral function, human immunity, and recognition by therapeutic antibodies?

Investigational vaccine regimen safe but did not provide protection against HIV acquisition

Researchers report that vectored expression of a high-affinity ACE2 microbody protein establishes a high degree of protection from SARS-CoV-2

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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