Protein Aggregation News and Research

RSS

Scientists identify new toxic pathway for protein aggregates in ALS and FTLD

Led by professor Ludo Van Den Bosch, scientists from Belgium, the UK and the US have identified new processes that form protein "clumps" that are characteristic of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD).

17 Mar 2017

SBP scientists identify autophagy linked to beneficial effects of enduring temporary stress

Biologists have known for decades that enduring a short period of mild stress makes simple organisms and human cells better able to survive additional stress later in life.

15 Feb 2017

Spatial structure of amyloid fibrils linked to Parkinson's disease highly dependent on salt concentration

By combining two-dimensional infrared spectroscopy and atomic force microscopy, Amsterdam researchers have established that the spatial structure of amyloid fibrils related to Parkinson's disease is highly dependent on salt concentration during protein aggregation.

6 Feb 2017

Protein aggregation may trigger inflammatory response linked to neurodegenerative diseases

A recent review article published online in The FASEB Journal points to the "trigger" for the inflammatory response, caused by the immune system, that precedes Alzheimer's disease and other neurological conditions.

11 Jan 2017

New tool explains how proteins assemble into different liquid and gel-like solid states

A tool that uses light to manipulate matter inside living cells has begun to explain how proteins assemble into different liquid and gel-like solid states, a key to understanding many critical cellular operations.

30 Dec 2016

Super-resolution fluorescence microscopy sheds light on brain’s molecular mechanism

Advances in microscopy techniques have often triggered important discoveries in the field of neuroscience, enabling vital insights in understanding the brain and promising new treatments for neurodegenerative diseases such as Alzheimer's and Parkinson's.

29 Dec 2016

Understanding nucleation process could be critical for treating Alzheimer's disease or Type 2 diabetes

Whether it is clouds or champagne bubbles forming, or the early onset of Alzheimer's disease or Type 2 diabetes, a common mechanism is at work: nucleation processes.

24 Nov 2016

Distinct structures of tau protein aggregates may help determine type of dementia, study shows

The distinct structures of toxic protein aggregates that form in degenerating brains determine which type of dementia will occur, which regions of brain will be affected, and how quickly the disease will spread, according to a study from the Peter O'Donnell Jr. Brain Institute.

31 Oct 2016

FMP initiates new project for early detection of Parkinson's disease with magnetized xenon gas

A new project for the early detection of Parkinson's disease with strongly magnetized xenon gas has been initiated at FMP. The team led by physicist Leif Schröder has received a three-year grant from the Michael J. Fox Foundation for Parkinson's Research.

20 Oct 2016

Researchers propose new way for early diagnosis of neurodegenerative diseases

A preclinical test that may open new perspectives in the diagnosis of neurological disorders. This is the result accomplished by a group of researchers from the Center of Complexity and Biosystems of the University of Milan, who just published their work on 'Physical Review Applied'.

21 Sep 2016

MGH investigators discover key molecules essential for sensing proteasome dysfunction

Maintaining appropriate levels of proteins within cells largely relies on a cellular component called the proteasome, which degrades unneeded or defective proteins to recycle the components for the eventual assembly of new proteins.

16 Aug 2016

TSRI study reveals new approach to intervene in deadly disease

In a new study, scientists at The Scripps Research Institute have identified drug candidates that can boost a cell's ability to catch the "typos" in protein production that can cause a deadly disease called amyloidosis.

From Paxman 21 Jul 2016

Metallic molecule offers real-time monitoring of amyloid plaques in patients with Alzheimer's

A metallic molecule being studied at Rice University begins to glow when bound to amyloid protein fibrils of the sort implicated in Alzheimer's disease. When triggered with ultraviolet light, the molecule glows much brighter, which enables real-time monitoring of amyloid fibrils as they aggregate in lab experiments.

11 Jul 2016

Actin filaments may be key to molecular machinery that forms, stores long-term memories

Thank the little "muscles" in your neurons for allowing you to remember where you live, what your friends and family look like and a lot more.

19 Apr 2016

Versatile Automated Microplate Sample Screening Applications

In this interview, News Medical speaks Tobias Pusterla, Ph.D from BMG Labtech about versatile automated microplate sample screening applications.

From BMG LABTECH GmbH 30 Mar 2016

Extracellular Vesicle Isolation and Characterization

In this interview, News Medical talks to Dr. Carly Ross, from Beckman Coulter Life sciences about extracellular vesicle isolation and characterization.

From Beckman Coulter Life Sciences - Flow Cytometry 23 Mar 2016

Anti-cancer drug delays onset of Alzheimer's disease

Researchers have identified a drug that targets the first step in the toxic chain reaction leading to the death of brain cells, suggesting that treatments could be developed to protect against Alzheimer's disease, in a similar way to how statins are able to reduce the risk of developing heart disease.

15 Feb 2016

Alpha-synuclein protein involved in Parkinson's disease pathology does not behave like a 'prion'

In Parkinson's disease, the protein "alpha-synuclein" aggregates within neurons of patients and appears to propagate across interconnected areas of the brain. How this happens remains largely unknown.

6 Jan 2016

Aquinnah secures $5 million private equity investment from Takeda

Aquinnah Pharmaceuticals announced today that it has received a $5 Million investment from Takeda Pharmaceutical Company, Limited, in it's first private equity financing. The company has assembled a world-class team of drug developers and an exceptional Scientific Advisory Board in the fields of Amyotrophic Lateral Sclerosis (ALS), protein and RNA regulation, and neurodegenerative diseases.

21 Dec 2015

Protein aggregates as harmful as neurodegenerative-disease-related proteins, shows study

Scientists at the forefront of cutting-edge research into neurodegenerative diseases such as Alzheimer’s and Parkinson’s have shown that the mere presence of protein aggregates may be as important as their form and identity in inducing cell death in brain tissue.

20 Nov 2015