Protein Expression News and Research

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Denosumab may benefit postmenopausal patients with hormone receptor-negative breast tumors and RANK protein expression

The drug denosumab is currently used to treat osteoporosis and bone metastases. For more than a decade, its potential therapeutic benefit in the treatment of breast cancer has also been studied.

7 Mar 2023

Naked mRNA delivered using needle-free PYRO injection presents a safe and effective potential vaccination method

Researchers examined the vaccination effects and local antigen expression efficiency of a needle-free vaccination technique involving pyro-drive liquid jet injection (PYRO) to deliver the naked messenger ribonucleic acid (mRNA) to the skin.

3 Mar 2023

Monitoring the presence of bovine meat and milk factor protein expression may help identify people at risk of colorectal cancer

Bovine meat and milk factors (BMMFs)-; initially identified by de Villiers et al. in 2014-; represent a class of infectious agents in beef and cow's milk that have been linked to the development of cancer.

22 Feb 2023

Mount Sinai study sheds new light on the role of DNA methylation in Alzheimer's disease

Mount Sinai researchers have published a study in Alzheimer's & Dementia: The Journal of the Alzheimer's Association that sheds new light on the role of DNA methylation in Alzheimer's disease (AD).

22 Feb 2023

Alternative splicing plays a role in compensating for loss of gene function

Living organisms have a knack for persisting in the face of challenges. For instance, when genes malfunction, organisms may be able to compensate by activating redundant genes with similar functions, called paralogs.

21 Feb 2023

New method for capturing moments during protein translation

Nascent polypeptide chains or polypeptidyl-tRNAs (pep-tRNAs) occur transiently during protein synthesis. The potential to study these intermediates and better understand their role in processes like gene regulation has been greatly enhanced by the development of a process termed PETEOS—short for peptidyl-tRNA enrichment using organic extraction and silica adsorption.

10 Feb 2023

Deletion of a tumor suppressor gene promotes luminal breast cancer development and resistance to endocrine therapy

A research team from LKS Faculty of Medicine, the University of Hong Kong (HKUMed) discovered that somatic deletion of a tumor suppressor gene AKTIP promotes luminal breast cancer development and resistance to endocrine therapy.

3 Feb 2023

Pulmonary surfactant-mediated inflammatory response against SARS-CoV-2

Researchers discuss the role of a surfactant-mediated inflammatory response employed by human lungs against SARS-CoV-2.

3 Feb 2023

Highly effective detection of cancer biomarkers using CRISPR

Most cancer diagnostic techniques rely on uncomfortable and invasive procedures, such as biopsies, endoscopies or mammograms.

1 Feb 2023

A machine-learning approach to identify asthma subtypes based on molecular signatures

Researchers determine whether protein expression in nasal fluid samples could assist in the diagnosis of severe asthma subtypes.

31 Jan 2023

Using systems biology research to alter the properties of carcinogenic cells in the lungs

KAIST (President Kwang Hyung Lee) announced on January 30th that a research team led by Professor Kwang-Hyun Cho from the Department of Bio and Brain Engineering succeeded in using systems biology research to change the properties of carcinogenic cells in the lungs and eliminate both drug resistance and their ability to proliferate out to other areas of the body.

29 Jan 2023

Protein adduction and p53 tumor suppressor inhibition

Researchers assessed the impact of protein adduction on p53 tumor suppressor inhibition.

27 Jan 2023

Study shows cutaneous touch neuronal cells to be critical for sexual receptiveness

Researchers studied the social relevance of G protein-coupled receptor (GPCR) Mrgprb4-lineage touch neurons in sexual touch and receptivity.

25 Jan 2023

Study suggests cortical hemorrhage in fetal brain may be associated with COVID-19

Researchers evaluated the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on fetal brain health.

25 Jan 2023

Researchers discover the gene responsible for radiation resistance in mutant IDH1 glioma

It's a good news, bad news story. Patients whose brain tumors have a mutated enzyme called IDH1 typically live longer than those without the mutation.

24 Jan 2023

Mutations may underlie how the most aggressive lymphomas arise and resist therapies

The key to understanding how the most aggressive lymphomas arise and resist current therapies may lie in mutations that disrupt a critical natural selection process among antibody-producing B cells, according to a multi-institutional preclinical study led by Weill Cornell Medicine investigators.

19 Jan 2023

Protein Expression News and Research

Denosumab may benefit postmenopausal patients with hormone receptor-negative breast tumors and RANK protein expression

Naked mRNA delivered using needle-free PYRO injection presents a safe and effective potential vaccination method

Monitoring the presence of bovine meat and milk factor protein expression may help identify people at risk of colorectal cancer

Mount Sinai study sheds new light on the role of DNA methylation in Alzheimer's disease

Alternative splicing plays a role in compensating for loss of gene function

New method for capturing moments during protein translation

Deletion of a tumor suppressor gene promotes luminal breast cancer development and resistance to endocrine therapy

Pulmonary surfactant-mediated inflammatory response against SARS-CoV-2

Highly effective detection of cancer biomarkers using CRISPR

A machine-learning approach to identify asthma subtypes based on molecular signatures

Using systems biology research to alter the properties of carcinogenic cells in the lungs

Protein adduction and p53 tumor suppressor inhibition

Study shows cutaneous touch neuronal cells to be critical for sexual receptiveness

Study suggests cortical hemorrhage in fetal brain may be associated with COVID-19

Researchers discover the gene responsible for radiation resistance in mutant IDH1 glioma

Mutations may underlie how the most aggressive lymphomas arise and resist therapies

Artemisia argyi plant extracts and phytochemicals shown to inhibit SARS-CoV-2 in new research

Research uncovers a new way to boost the effectiveness of RNA therapies

Protein expression signature distinguishes early from late stage diffuse alveolar damage

Discovery of cellular uptake pathway for larger molecules can be harnessed to create new drugs

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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