Protein Synthesis News and Research

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Forward genetic screening reveals important pathways for sleep regulation in C. elegans

Although the regulation of sleep—how much, when, and how sleep occurs—is mainly considered to be controlled by the brain, sleep deprivation also affects the body, and signals from the body can affect sleep.

27 Mar 2023

Molecular mechanism involved in the development of type 2 diabetes discovered

Type 2 diabetes is a chronic disease in which the body does not produce enough insulin, or does not use it efficiently.

23 Mar 2023

Can increasing nut intake prevent frailty in older women?

A recent study explored the potential for reducing frailty in older women by increased nut consumption.

22 Mar 2023

Newly found protein complex plays a crucial role in messenger RNA stability

Two proteins come together to protect and stabilize RNA as it carries muscle-forming code through the cell. Further understanding this RNA-stabilizing complex may have implications for influencing muscle recovery and disease treatment.

9 Mar 2023

Newfound mechanism helps the heart to toggle between maintenance and energy-boost mode

Researchers at the Centre for Genomic Regulation in Barcelona have discovered a mechanism involving ribosomes which helps the heart toggle between a 'regular maintenance mode' for day-to-day function and an 'energy-boost mode' which aids recovery for high-demand situations including heart attacks.

7 Mar 2023

Exploring the neuroprotective potential of cell-penetrating peptides, extracellular vesicles, and micro ribonucleic acids

In a recent review published in Biomedicines, researchers explored extracellular vesicles (EVs), cell-penetrating peptides (CPPs), and micro ribonucleic acids (miRNAs) as therapies for neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD).

1 Mar 2023

New insights into how amino acids shaped the genetic code of ancient microorganisms

By simulating early Earth conditions in the lab, researchers have found that without specific amino acids, ancient proteins would not have known how to evolve into everything alive on the planet today-;including plants, animals, and humans.

27 Feb 2023

Different cellular building blocks are not produced at the same time, research shows

Textbooks will tell you that in dividing cells, the production of new DNA peaks during the S-phase, while production of other macromolecules, such as proteins, lipids, and polysaccharides, continues at more or less the same level.

27 Feb 2023

What is the effect of maternal circulating amino acids on offspring birthweight?

Researchers examined the effect of serum levels of 20 amino acids in a mother during pregnancy on offspring birthweight in a two-sample summary data Mendelian randomization framework.

27 Feb 2023

Study on modern diets and how they impact the environment

A review article published in the journal Nutrients describes the impact of six popular diets on human health as well as planetary health. The health and environmental impacts of these diets have been compared in the review using carbon footprint databases and representative meal plans.

14 Feb 2023

Molecular switch regulates autophagy in plants

Autophagy, or "self-eating", is an essential cellular quality control mechanism that clears the cell of protein aggregates and damaged organelles. This mechanism is inactive under normal conditions and only triggered upon persistent cellular stress.

10 Feb 2023

New method for capturing moments during protein translation

Nascent polypeptide chains or polypeptidyl-tRNAs (pep-tRNAs) occur transiently during protein synthesis. The potential to study these intermediates and better understand their role in processes like gene regulation has been greatly enhanced by the development of a process termed PETEOS—short for peptidyl-tRNA enrichment using organic extraction and silica adsorption.

10 Feb 2023

Penn scientists discover a cellular pathway that keeps Ebola virus from exiting human cells

In their evolutionary battle for survival, viruses have developed strategies to spark and perpetuate infection. Once inside a host cell, the Ebola virus, for example, hijacks molecular pathways to replicate itself and eventually make its way back out of the cell into the bloodstream, where it can spread further.

3 Feb 2023

Study shows COVID-19 induces body fat and other metabolic changes

In a recent study published in the journal Cureus, researchers explored the relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and levels of serum insulin, body fat distribution, and insulin resistance (IR) estimated by homeostasis model assessment (HOMA).

29 Jan 2023

The loss of epigenetic information accelerates the aging process

A new study in the journal Cell aimed to determine whether epigenetic changes are a cause of mammalian aging.

15 Jan 2023

LJI scientists uncover how OGT enzyme keeps cells healthy

Researchers at La Jolla Institute for Immunology have at last uncovered how an enzyme called O-GlcNAc transferase (OGT) keeps cells healthy.

12 Jan 2023

Cells live longer when they exchange metabolic products with each other

When cells exchange metabolic products with other cells, they live longer. This new finding comes from a research team at Charité – Universitätsmedizin Berlin, which made the discovery in a study using yeast cells.

6 Jan 2023

Study offers novel insights into the elongation dynamics of eukaryotic cells

Life depends on the precise functioning of several proteins synthesized in cells by ribosomes. This diverse set of proteins, known as a proteome, is maintained by the robust translation elongation of amino acid sequences taking place in the ribosomes.

5 Jan 2023

Scientists explore synthesis of griffithsin in cell-free systems

A new study described the cell-free manufacturing of griffithsin (GRFT), a broad-spectrum antiviral protein.

28 Dec 2022

Study explores cellular alterations in six distinct neurodegenerative diseases

A perplexing range of neurodegenerative diseases are known to attack distinct regions of the brain, causing severe cognitive and motor deficit.

21 Dec 2022

Protein Synthesis News and Research

Forward genetic screening reveals important pathways for sleep regulation in C. elegans

Molecular mechanism involved in the development of type 2 diabetes discovered

Can increasing nut intake prevent frailty in older women?

Newly found protein complex plays a crucial role in messenger RNA stability

Newfound mechanism helps the heart to toggle between maintenance and energy-boost mode

Exploring the neuroprotective potential of cell-penetrating peptides, extracellular vesicles, and micro ribonucleic acids

New insights into how amino acids shaped the genetic code of ancient microorganisms

Different cellular building blocks are not produced at the same time, research shows

What is the effect of maternal circulating amino acids on offspring birthweight?

Study on modern diets and how they impact the environment

Molecular switch regulates autophagy in plants

New method for capturing moments during protein translation

Penn scientists discover a cellular pathway that keeps Ebola virus from exiting human cells

Study shows COVID-19 induces body fat and other metabolic changes

The loss of epigenetic information accelerates the aging process

LJI scientists uncover how OGT enzyme keeps cells healthy

Cells live longer when they exchange metabolic products with each other

Study offers novel insights into the elongation dynamics of eukaryotic cells

Scientists explore synthesis of griffithsin in cell-free systems

Study explores cellular alterations in six distinct neurodegenerative diseases

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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