The proteome is the entire complement of proteins expressed by a genome, cell, tissue or organism. More specifically, it is the expressed proteins at a given time point under defined conditions. The term is a blend of proteins and genome.
COSMIC-3D, the most comprehensive system for exploring cancer mutations in three dimensions, is launched today by COSMIC, based at the Wellcome Trust Sanger Institute, in collaboration with Astex Pharmaceuticals, Cambridge, UK.
Scientists from the Center for Self-assembly and Complexity (CSC) successfully isolated a cancer-prone protein by fishing out the proteins using 'molecular bait'.
The genomes of cancer cells--cells that do not obey signals to stop reproducing--are riddled with genetic mutations, causing them inadvertently to make many dysfunctional proteins.
In a land where survival is precarious, Komodo dragons thrive despite being exposed to scads of bacteria that would kill less hardy creatures.
The Helmholtz Zentrum München has published results of the largest genome-wide association study on proteomics to date.
Have you ever collected coins, cards, toy trains, stuffed animals? Did you feel the need to complete the set? If so, then you may be a completist. A completist will go to great lengths to acquire a complete set of something.
The majority of patients in neonatal intensive care units are premature babies, who often have infectious (congenital pneumonia) or noninfectious (tachypnea, infant respiratory distress syndrome) respiratory pathologies.
Scientists at Washington State University and Johns Hopkins Medical School have discovered a fast, noninvasive method that could lead to the early diagnosis of colorectal cancer.
Researchers at St. Jude Children's Research Hospital have discovered the way toxic proteins linked to the most common forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) incapacitate membrane-less organelles inside cells.
Experts from the V. I. Kulakov Research Center for Obstetrics, Gynecology and Perinatology and the Moscow Institute of Physics and Technology have devised a method that uses the urinary proteome to diagnose conditions in newborn babies.
MIT researchers have developed a new technique for imaging brain tissue at multiple scales, allowing them to peer at molecules within cells or take a wider view of the long-range connections between neurons.
Biology and computing have joined forces to create a piece of software that analyses mutations in proteins; these mutations are potential inducers of diseases, such as cancer.
“IDPs” is now a widely used acronym that stands for “intrinsically disordered proteins.” It is the term generally used by the scientific community to refer to a wide variety of proteins that do not have a stable 3D structure and are instead characterized by a high extent of local mobility, disorder and many conformers that are accessible at room temperature.
In what is believed to be the largest study of its kind, scientists at the Pacific Northwest National Laboratory, Johns Hopkins University and their collaborators from institutions across the nation have examined the collections of proteins in the tumors of 169 ovarian cancer patients to identify critical proteins present in their tumors.
Overeating can lead to health issues that can shorten one's life, such as obesity, diabetes and heart disease.
In a study appearing in the June 21 issue of JAMA, Peter Ganz, M.D., of the University of California-San Francisco, and colleagues conducted a study to develop and validate a score to predict risk of cardiovascular outcomes among patients with coronary heart disease using analysis of circulating proteins.
Johns Hopkins Medicine researchers report that rising blood levels of a protein called hematoma derived growth factor (HDGF) are linked to the increasing severity of pulmonary arterial hypertension, a form of damaging high blood pressure in the lungs.
Endometriosis is a chronic, often painful disease affecting up to 10 percent of women of reproductive age in the U.S. How it develops is not well understood, and detecting it with certainty requires surgery.
Scientists at The Scripps Research Institute have developed a powerful new method for finding drug candidates that bind to specific proteins.
Scientists from EPFL and ETHZ have developed a powerful tool for exploring and determining the inherent biological differences between individuals, which overcomes a major hurdle for personalized medicine.