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Psychosis means abnormal condition of the mind, and is a generic psychiatric term for a mental state often described as involving a "loss of contact with reality". People suffering from psychosis are said to be ''psychotic.''
Successful antipsychotic treatment may alter striatal connectivity

Successful antipsychotic treatment may alter striatal connectivity

Connectivity within the striatum changes as psychotic symptoms improve in patients treated with second-generation antipsychotics, a study shows. [More]
Omega-3 benefits may be sustained in early psychosis

Omega-3 benefits may be sustained in early psychosis

The positive effects of omega-3 supplementation seen in patients at high risk of psychosis in a previous randomised, controlled trial may be sustained, the investigators reported at the International Early Psychosis Conference in Tokyo, Japan. [More]
Janssen announces submission of NDA for three-month paliperidone palmitate

Janssen announces submission of NDA for three-month paliperidone palmitate

Janssen Research & Development, LLC today announced the submission of a New Drug Application (NDA) for three-month atypical antipsychotic paliperidone palmitate to the U.S. Food and Drug Administration. The NDA seeks approval for the medication as a treatment for schizophrenia in adults. [More]
Suicidal ideation link to suicide strong in schizophrenia spectrum disorders

Suicidal ideation link to suicide strong in schizophrenia spectrum disorders

The association between suicidal ideation and later suicide is much stronger in patients with schizophrenia spectrum psychosis than in those with mood disorders, show results of a systematic meta-analysis. [More]
Cue processing altered in siblings of schizophrenia patients

Cue processing altered in siblings of schizophrenia patients

The siblings of patients with schizophrenia have altered activity in the ventral striatum during reward anticipation and receipt, a study shows. [More]
ISBD Task Force examines suicide predictors

ISBD Task Force examines suicide predictors

The International Society for Bipolar Disorders Task Force on Suicide has published a meta-analysis of predictors of suicide attempts and deaths. [More]
Genetics underpin bullying victimisation influence on paranoia

Genetics underpin bullying victimisation influence on paranoia

Bullying victimisation in childhood may indicate genetic risk for later psychosis, rather than being an environmental trigger, say UK researchers. [More]
Aspirin can improve efficacy of schizophrenia treatments

Aspirin can improve efficacy of schizophrenia treatments

A new study shows that some anti-inflammatory medicines, such as aspirin, estrogen, and Fluimucil, can improve the efficacy of existing schizophrenia treatments. This work is being presented at the European College of Neuropsychopharmacology conference in Berlin. [More]
Cannabis use during adolescence: an interview with Dr Edmund Silins

Cannabis use during adolescence: an interview with Dr Edmund Silins

We know quite a lot about the effects of cannabis on the body and brain but there is still a need to better understand its impact on the health, well-being and development of long term users. [More]
Groundbreaking study tracks precise path of rabies to the central nervous system

Groundbreaking study tracks precise path of rabies to the central nervous system

Rabies causes acute inflammation of the brain, producing psychosis and violent aggression. The virus, which paralyzes the body's internal organs, is always deadly for those unable to obtain vaccines in time. Some 55,000 people die from rabies every year. [More]

Psychotic disorders confer ‘staggering’ increase in unnatural death risk

Mortality among patients during the first 10 years after first-episode psychosis is marked by a huge increase in the rate of unnatural death relative to the general population, a UK study shows. [More]
Neuropsychiatric symptoms variable in early Parkinson’s disease

Neuropsychiatric symptoms variable in early Parkinson’s disease

The prevalence of neuropsychiatric symptoms is increased in patients with early Parkinson’s disease, although many remain stable over time, shows follow-up of the Parkinson’s Progression Markers Initiative. [More]
Researchers take major step forward in accurate diagnosis of people experiencing psychosis

Researchers take major step forward in accurate diagnosis of people experiencing psychosis

A study led by University of North Carolina at Chapel Hill researchers represents an important step forward in the accurate diagnosis of people who are experiencing the earliest stages of psychosis. [More]
Researchers identify control mechanism for mood disorders

Researchers identify control mechanism for mood disorders

Researchers at University of California, San Diego School of Medicine have identified a control mechanism for an area of the brain that processes sensory and emotive information that humans experience as "disappointment." [More]
FDA approves Contrave extended-release tablets for chronic weight management

FDA approves Contrave extended-release tablets for chronic weight management

Takeda Pharmaceuticals U.S.A., Inc. and Orexigen® Therapeutics, Inc. jointly announced today that the U.S. Food and Drug Administration has approved Contrave® extended-release tablets as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index of 30 kg/m2 or greater (obese), or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition. [More]
Teen cannabis users 60% less likely to complete school or get a degree

Teen cannabis users 60% less likely to complete school or get a degree

Individuals who are daily users of cannabis before age 17 are over 60% less likely to complete high school or obtain a degree compared to those who have never used the drug, new research published in The Lancet Psychiatry journal shows. [More]
Canada funds 22 inventive ideas for improving health in low-resource countries

Canada funds 22 inventive ideas for improving health in low-resource countries

Grand Challenges Canada, funded by the Government of Canada, today announced $2.4 million in seed funds shared between 22 projects from Canada and nine developing nations, to pursue inventive new ideas for improving health in low-resource countries. [More]
OCD diagnosis raises risk of subsequent schizophrenia

OCD diagnosis raises risk of subsequent schizophrenia

Patients who are diagnosed with obsessive–compulsive disorder are at increased risk of developing schizophrenia and schizophrenia spectrum disorders, a longitudinal study reports. [More]
Childhood inflammation linked to adult psychosis

Childhood inflammation linked to adult psychosis

Elevated levels of the inflammatory marker interleukin -6 in childhood are associated with an increased risk of psychosis and depression in adulthood, research shows. [More]
Blood test could help gauge psychosis risk

Blood test could help gauge psychosis risk

Researchers have developed a multiplex blood assay that may aid the identification of high-risk individuals who will progress to psychosis. [More]