Pulmonary Hypertension News and Research

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Pulmonary arterial hypertension (PAH) is a condition involving high blood pressure and structural changes in the walls of the pulmonary arteries, which are the blood vessels that connect the right side of the heart to the lungs. Affecting people of all ages and ethnic backgrounds - but most commonly found in young women of child-bearing years - the disease has historically been chronic and incurable, with a poor survival rate. PAH is often not diagnosed in a timely manner because its early symptoms can be confused with those of many other pulmonary and respiratory conditions. Symptoms include shortness of breath, extreme fatigue, dizziness, fainting, swollen ankles and legs and chest pain (especially during physical activity). With proper diagnosis, there are currently several therapies to alleviate symptoms and improve quality of life for PAH patients. The key is to find a PAH specialist and pursue immediate treatment.

Improving dialogue between healthcare professionals and patients in bladder cancer

In this interview, Dr. Ignacio Duran and Alex Filicevas focus on improving dialogue between healthcare professionals and patients, outlining ways in which we can encourage open discussion to improve the overall patient experience.

From Janssen Pharmaceuticals 1 Aug 2022

Chewing gum containing plant-based antiviral proteins neutralizes SARS-CoV-2 and influenza viruses

A new study has explored the entrapment efficacy of CTB-ACE2 chewing gum against different strains of SARS-CoV-2.

20 Jul 2022

Does high-dose inhaled nitric oxide improve respiratory function and outcomes among pregnant patients hospitalized with severe COVID-19 pneumonia?

Researchers demonstrated that inhaled nitric oxide 200 (iNO200) enhances oxygenation in pregnant COVID-19 patients with severe pneumonia.

13 Jul 2022

Discussing tools and resources to support the bladder cancer patient community

In this interview, Dr. Ignacio Durán and Alex Filicevas discuss key challenges and opportunities in the bladder cancer disease landscape and the future of care. This episode focuses on the bladder cancer patient support landscape, including a review of the tools and resources available to the community, as well as key unmet needs to address.

From Janssen Pharmaceuticals 4 Jul 2022

Understanding the impact of bladder cancer on daily life before and after diagnosis

In this interview, Dr. Ignacio Durán and Alex Filicevas, discuss key challenges and opportunities in the bladder cancer disease landscape and the future of care. They focus on the quality of life for patients and delve into the impact bladder cancer has on daily life, both before and after diagnosis and treatment, from the holistic perspective of both patients and HCPs.

From Janssen Pharmaceuticals 4 Jul 2022

Patients with COVID-19 pneumonitis and moderate to severe ARDS treated with sildenafil

A new study published in the British Journal of Anaesthesia aimed to determine whether sildenafil could improve gaseous exchange in patients with COVID-19 ARDS with pulmonary hypertension, RV dysfunction, or both.

17 May 2022

Study reveals underlying signaling pathway that results in pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a type of high blood pressure in the lungs, in which blood vessels are narrowed, blocked or destroyed, causing the heart to work harder and, in time, result in cardiac weakness and failure.

6 May 2022

Rapid infusion of NaHCO3 bolus after extensive resuscitation leads to higher blood flows to the brain and heart

A new study examines the effect of rapid infusion of 2meq/kg of sodium bicarbonate (NaHCO3) in an ovine model on gas exchange and coronary and cerebral perfusion in the immediate post-resuscitation phase.

22 Apr 2022

Johns Hopkins Children’s Center doctors save a newborn baby with congenital diaphragmatic hernia

Sarah Gonzalez was just 13 weeks pregnant in 2018 when she received "terrifying" news during a routine ultrasound.

19 Apr 2022

Scientific statement from the American Heart Association on COVID-19 and cardiovascular complications in children and adolescents

A recent scientific statement published in Circulation reviewed the current knowledge on COVID-19.

13 Apr 2022

EMA issues qualification opinion for islet autoantibodies as enrichment biomarkers for T1D prevention trials

Critical Path Institute's Type 1 Diabetes Consortium (T1DC) today announced that the European Medicines Agency has issued a positive qualification opinion for pancreatic islet autoantibodies as enrichment biomarkers for type 1 diabetes (T1D) prevention trials.

5 Apr 2022

Novel transcatheter repair system for tricuspid regurgitation shows promising results at one year

Patients with tricuspid regurgitation, a common and debilitating form of valvular heart disease, who received a novel investigational device intended to repair the defective valve experienced significant improvements in blood flow through the heart and in quality of life at one year, according to research presented at the American College of Cardiology's 71st Annual Scientific Session.

5 Apr 2022

Study reveals how to identify and avoid risks related to mitochondrial therapeutic interventions

Research carried out at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has demonstrated that mixing mitochondrial DNAs (mtDNAs) of different origins can have damaging effects over the medium and long term.

16 Mar 2022

People with congenital heart defect hospitalized for COVID-19 are at highest risk of severe illness

People with a congenital heart defect who were hospitalized with COVID-19 infection were at higher risk for severe illness or death than those without a heart defect, according to new research published today in the American Heart Association's flagship, peer-reviewed journal Circulation.

7 Mar 2022

Study identifies a link between mortality of newborns on ECMO and red blood cell transfusion volume

Newborns in respiratory failure who require the life-sustaining support of ECMO also require transfusion of red blood cells. But a new study indicates that the higher volume of these oxygen-carrying blood cells the babies receive, the higher their mortality rate.

14 Feb 2022

Study examines whether viagra-like drug may be effective in treating vascular dementia

A new study, published today in Alzheimer's & Dementia, tested whether tadalafil, a drug closely related to Viagra, may be effective in treating people with vascular dementia.

9 Feb 2022

Study shows positive outcomes in COVID-19 patients who underwent lung transplants

For many COVID-19 patients with irrecoverable lung damage, transplantation is the only option for survival. However, there is limited information about the long-term outcomes of these patients, including postoperative complications, hospital length of stay and survival.

3 Feb 2022

New MRI technology to expand imaging access for patients with implanted medical devices and obesity

New MRI technology, developed by Siemens in collaboration with researchers at The Ohio State University College of Medicine and College of Engineering, will expand imaging access for patients with implanted medical devices, severe obesity and claustrophobia.

21 Jan 2022

Erectile dysfunction medication found to intensify abdominal aortic aneurysms in mice

In a laboratory study in mice, sildenafil, a commonly used erectile dysfunction medication, was found to worsen abdominal aortic aneurysms, indicating additional research may be needed to determine if the medication may have the same effect on people, according to new research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.

5 Jan 2022

Both symptomatic and asymptomatic COVID-19 associated with increased risk of cardiovascular events

Researcers determine the risk of symptomatic and asymptomatic SARS-CoV-2 infection on post-acute cardiovascular events and all-cause mortality.

4 Jan 2022