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Scientists examine how neural responses change over time in patients with Parkinson's disease

Scientists examine how neural responses change over time in patients with Parkinson's disease

Neuroscientists peered into the brains of patients with Parkinson's disease and two similar conditions to see how their neural responses changed over time. [More]
New, non-invasive way to monitor progression of Parkinson's disease may help improve treatment

New, non-invasive way to monitor progression of Parkinson's disease may help improve treatment

A new, non-invasive way to track the progression of Parkinson's disease could help evaluate experimental treatments to slow or stop the disease's progression. [More]
Novel PET radiotracer reveals epigenetic activity in the human brain for the first time

Novel PET radiotracer reveals epigenetic activity in the human brain for the first time

A novel PET radiotracer developed at the Martinos Center for Biomedical Imaging at Massachusetts General Hospital is able for the first time to reveal epigenetic activity - the process that determines whether or not genes are expressed - within the human brain. [More]
Patients with schizophrenia demonstrate specific leftward asymmetry for globus pallidus volume

Patients with schizophrenia demonstrate specific leftward asymmetry for globus pallidus volume

A Japanese research group found that patients with schizophrenia demonstrated a specific leftward volumetric asymmetry for the globus pallidus, one of the basal ganglia of the brain. The basal ganglia are involved in motivation and volition, the impairment of which may result in difficulties in social life. This finding is expected to help elucidate the underlying pathological mechanisms of schizophrenia. Moreover, it will be a step toward the development of therapeutic strategies for schizophrenia. [More]
Pitt experts lead gene therapy clinical trial in Parkinson's disease patients

Pitt experts lead gene therapy clinical trial in Parkinson's disease patients

Experts at the University of Pittsburgh School of Medicine are leading the second arm of a clinical trial using gene therapy to relieve the symptoms of tremor and mobility impairment in patients with Parkinson's disease. [More]
Astrocytes implicated in preclinical AD

Astrocytes implicated in preclinical AD

Astrocytes are activated in the brains of people with autosomal dominant Alzheimer’s disease long before symptoms appear and even before amyloidosis begins, a study shows. [More]
Slow walking speed may herald Alzheimer’s disease

Slow walking speed may herald Alzheimer’s disease

A slow walking speed in elderly people is associated with the presence of β-amyloid in their brains, research shows. [More]
Olfactory function may inform Parkinson’s prognosis

Olfactory function may inform Parkinson’s prognosis

Olfactory function is preserved in about a quarter of patients with Parkinson’s disease, and may be predictive of disease course, say researchers. [More]
Researchers examine use of MRI after birth to identify children at risk of later academic impairment

Researchers examine use of MRI after birth to identify children at risk of later academic impairment

School age children who are born prematurely are more likely to have low mathematical achievement, thought to be associated with reduced working memory and number skills, according to a new study published today in the neurology journal Brain. [More]
Study shows food craving may be hard-wired into the brain of overweight patients

Study shows food craving may be hard-wired into the brain of overweight patients

An international group of researchers have found that food craving activates different brain networks between obese and normal weight patients. [More]
Putaminal serotonergic innervation flags levodopa-induced dyskinesia risk

Putaminal serotonergic innervation flags levodopa-induced dyskinesia risk

Increased serotonergic fibre innervation relative to dopaminergic fibre availability may be a potential marker of disease progression in Parkinson’s disease patients and a possible warning of levodopa-induced dyskinesia, indicates an in vivo imaging study. [More]
Resting-state connectivity changes underpinning ICDs identified

Resting-state connectivity changes underpinning ICDs identified

The presence of impulse control disorders is associated with reduced resting-state connectivity between part of the associative striatum and both associative and limbic cortical regions in patients with Parkinson’s disease, a study suggests. [More]
New Penn Medicine study reveals how sleep deprivation increases intake of fat

New Penn Medicine study reveals how sleep deprivation increases intake of fat

Experts have warned for years that insufficient sleep can lead to weight gain. A new Penn Medicine study found that not only do we consume more food following a night of total sleep deprivation, but we also we consume more fat and less carbohydrates and a region of the brain known as the salience network is what may lead us to eat more fat. [More]
International study identifies genetic factors that influence the size of brain structures

International study identifies genetic factors that influence the size of brain structures

An international study, which included researchers from NUI Galway, has identified significant genetic factors that influence the size of structures within the brain. It is hoped these new insights may help scientists better understand disorders such as schizophrenia, Alzheimer's disease and epilepsy. [More]
At-home test sniffs out prodromal Parkinson’s disease

At-home test sniffs out prodromal Parkinson’s disease

An at-home olfactory test helps to identify people with an increased risk of having dopamine transporter imaging indicative of early Parkinson’s disease, show data from the Parkinson Associated Risk Syndrome study. [More]
Successful antipsychotic treatment may alter striatal connectivity

Successful antipsychotic treatment may alter striatal connectivity

Connectivity within the striatum changes as psychotic symptoms improve in patients treated with second-generation antipsychotics, a study shows. [More]
Changes in the brain may explain premature babies' higher risk of neurodevelopmental disorders

Changes in the brain may explain premature babies' higher risk of neurodevelopmental disorders

Disturbances in the early stages of brain growth, such as preterm birth - when many of the brain's structures have not yet fully developed - appears to affect the brain's neuro-circuitry, which may explain premature babies' higher risk of neurodevelopmental disorders including ADHD and autism spectrum disorder. [More]
Brain imaging could assist bipolar depression diagnosis

Brain imaging could assist bipolar depression diagnosis

Researchers have identified structural brain differences that could help to distinguish patients with unipolar and bipolar depression. [More]
Subcortical brain regions play key role in memorization process during sleep

Subcortical brain regions play key role in memorization process during sleep

According to researchers at the University of Montreal, the regions of the brain below the cortex play an important role as we train our bodies' movements and, critically, they interact more effectively after a night of sleep. [More]
In vivo dopaminergic imaging strongly correlates with brain pathology

In vivo dopaminergic imaging strongly correlates with brain pathology

Striatal dopamine transporter binding, assessed using single-photon emission computed tomography, is strongly correlated with substantia nigra cell counts assessed at postmortem, say the authors of a study. [More]
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