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New ovarian atlas paves the way for extended fertility and hormone restoration

A new "atlas" of the human ovary provides insights that could lead to treatments restoring ovarian hormone production and the ability to have biologically related children, according to University of Michigan engineers.

5 Apr 2024

DNA repair process key to memory formation, study finds

Study reveals that learning triggers a series of molecular events including DNA damage and repair in hippocampal neurons, mediated by TLR9, crucial for memory formation.

31 Mar 2024

Machine learning identifies key cellular communities in soft tissue sarcoma

Using novel machine learning tools developed at Stanford Medicine, researchers have mapped three distinct cellular configurations that correspond to clinical outcomes for patients with a rare, difficult-to-treat cancer called soft tissue sarcoma.

26 Mar 2024

GPT-4 shows expert-level accuracy in annotating cell types

GPT-4 can accurately interpret types of cells important for the analysis of single-cell RNA sequencing -- a sequencing process fundamental to interpreting cell types – with high consistency to that of time-consuming manual annotation by human experts of gene information, according to a study at Columbia University Mailman School of Public Health.

26 Mar 2024

Study reveals trigonelline as a therapeutic agent for mitochondrial dysfunction in aging

Sarcopenia is the age-related decline in skeletal muscle due to the wasting of myofiber.

26 Mar 2024

Mapping the aging brain's protein landscape

Researchers at LMU and the SyNergy Cluster of Excellence have analyzed how the proteome of specific brain cells changes as we age.

22 Mar 2024

Groundbreaking atlas maps over 80 blood stem cell types

Thanks to an unusual application of game theory and machine learning technology, a large team of scientists led by experts at Cincinnati Children's has published the world's most detailed "atlas" of the many types of stem cells and early progenitors involved in producing human blood from diverse donors.

21 Mar 2024

New insights into upper tract urothelial carcinoma evolution and treatment

Researchers at Weill Cornell Medicine have performed the most comprehensive analysis to date of cancer of the ureters or the urine-collection cavities in the kidney, known as upper tract urothelial carcinoma (UTUC).

18 Mar 2024

Mapping the heart's cellular blueprint: New insights into cardiac structure and disease repair

Researchers unveil the complex cellular architecture of the heart using advanced RNA sequencing and imaging techniques, shedding light on the intricate organization of heart cells and their developmental pathways.

14 Mar 2024

Researchers identify T-cell subsets as effective therapeutic target for preventing transplant rejection

Houston Methodist researchers identified a troublesome subset of T-cells in transplant recipients that may be a more effective therapeutic target for preventing transplant rejection in patients.

14 Mar 2024

Man takes 217 COVID vaccines with no ill effects, shows immune boost

A case report of a 62-year-old man receiving 217 SARS-CoV-2 vaccinations over 29 months reveals no adverse effects, increased T-cells, and spike-specific antibodies, providing unique insights into the effects of hyper-vaccination on immune responses.

7 Mar 2024

Study uncovers unexpected level of complexity hidden within neutrophils

In a study published in Cell on March 5, Prof. Zhang Xiaoming at the Shanghai Institute of Immunity and Infection (SIII) of the Chinese Academy of Sciences and Profs. Gao Qiang, Fan Jia and Yang Li at Fudan University have uncovered an unexpected level of complexity hidden within neutrophils, which were previously thought to be a relatively uniform population of short-lived immune cells.

6 Mar 2024

Metal organic frameworks enhance immune response in experimental vaccine

Many vaccines, including vaccines for hepatitis B and whooping cough, consist of fragments of viral or bacterial proteins.

6 Mar 2024

Noninvasive gamma therapy may hold promise for treating chemo brain

Patients undergoing chemotherapy often experience cognitive effects such as memory impairment and difficulty concentrating -; a condition commonly known as "chemo brain."

6 Mar 2024

Scientists develop robust iPSC-derived rejuvenated T lymphocytes for cervical cancer treatment

Cervical cancer is among the most common malignancies affecting women worldwide. In 2020 alone, approximately 600,000 women were diagnosed with this disease, and over 314,000 died from it.

5 Mar 2024

Growing mini-organs from amniotic fluid to treat conditions before birth

A pioneering approach, developed by researchers at UCL and Great Ormond Street Hospital (GOSH), means human development can be observed in late pregnancy for the first time, raising the possibility of monitoring and treating congenital conditions before birth.

5 Mar 2024

Unraveling the complex cellular composition of aldosterone-producing adenomas

Researchers from Tokyo Medical and Dental University (TMDU) find that the cells that make up aldosterone-producing adenomas become more transcriptionally active and express higher levels of genes linked to hormone production over intratumoral differentiation.

1 Mar 2024