Retinoic Acid News and Research

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Retinoic Acid is a nutrient that that body needs in small amounts to function and stay healthy. All-trans retinoic acid is made in the body from vitamin A and helps cells to grow and develop, especially in the embryo. A form of all-trans retinoic acid made in the laboratory is put on the skin to treat conditions such as acne and is taken by mouth to treat acute promyelocytic leukemia (a fast-growing cancer in which there are too many immature blood-forming cells in the blood and bone marrow). All-trans retinoic acid is being studied in the prevention and treatment of other types of cancer. Also called ATRA, retinoic acid, tretinoin, and vitamin A acid.

New needle-free 'exosome' treatment to reduce wrinkles in UV-exposed mice

In the quest for a more youthful appearance, many people slather ointments on their skin or undergo injections of dermal fillers. But topical treatments often aren't very effective because they don't penetrate deep within the skin, whereas the results from injections typically last for only a few months and can be painful.

25 Sep 2019

Physiologists, researchers to discuss factors underlying cardiovascular disease at APS conference

International physiologists and researchers studying the kidney, high blood pressure and related medical conditions will convene next week at the American Physiological Society (APS) Aldosterone and ENaC in Health and Disease: The Kidney and Beyond Conference in Estes Park, Colo.

25 Sep 2019

Dietary vitamin A may protect against common skin cancer

Increasing the intake of dietary vitamin A may reduce the risk of developing cutaneous squamous cell carcinoma (SCC), according to a new study.

31 Jul 2019

Loose double-stranded RNA molecules spur skin rejuvenation

Want to smooth out your wrinkles, erase scars and sunspots, and look years younger? Millions of Americans a year turn to lasers and prescription drugs to rejuvenate their skin, but exactly how that rejuvenation works has never been fully explained.

From Johns Hopkins Medicine 16 Jul 2019

Aldo-keto reductase family 1 member B10 enzyme found in advanced liver diseases

Nonalcoholic steatohepatitis is associated with liver inflammation in patients with nonalcoholic fatty liver disease, and it can progress to liver fibrosis at an advanced stage, and also to hepatocellular carcinoma and portal hypertension.

12 Apr 2019

New therapy could help prolong useful vision and delay total blindness

Millions of Americans are progressively losing their sight as cells in their eyes deteriorate, but a new therapy developed by researchers at the University of California, Berkeley, could help prolong useful vision and delay total blindness.

14 Mar 2019

Scripps Research finds molecular cause of a group of rare autoimmune disorders

A team from Scripps Research has found a molecular cause of a group of rare autoimmune disorders in which the immune system attacks the body's own healthy cells.

20 Dec 2018

Gut microbiome plays role in immune system regulation, study finds

Scientist have long known that bacteria in the intestines, also known as the microbiome, perform a variety of useful functions for their hosts, such as breaking down dietary fiber in the digestive process and making vitamins K and B7.

19 Dec 2018

Scientists grow 3D, beating human heart tissue

Researchers at the University Medical Center Hamburg-Eppendorf have found a way to grow human heart tissue that can serve as a model for the atria of the heart.

8 Nov 2018

New research suggests power of zebrafish as tool for cancer drug discovery

The lab of Leonard Zon, MD, at Boston Children's Hospital has long been interested in making blood stem cells in quantity for therapeutic purposes.

24 Sep 2018

Researchers describe promising strategy to remove melanoma's most powerful defenses

Immunotherapies use the immune system to fight cancer. But cancers like melanoma have found ways to turn off the immune system, allowing them to resist treatments and often leading to recurrence.

16 Aug 2018

Combination of arsenic and existing leukemia drug may combat cancer

Investigators have discovered that arsenic in combination with an existing leukemia drug work together to target a master cancer regulator.

9 Aug 2018

Fourth-generation retinoid may have improved efficacy and safety profile to treat acne

Topical retinoids, which target retinoic acid receptors, are commonly used to treat acne. New research published in theBritish Journal of Dermatologyreveals that trifarotene, a fourth-generation retinoid with potent and selective activity against only one particular retinoic acid receptor, may have an improved efficacy and safety profile compared with less selective retinoids.

6 Jul 2018

Researchers discover novel function of fibroblast growth factor 2 for spermatogonial stem cell

A research team found a novel function of fibroblast growth factor 2, a self-renewal factor for spermatogonial stem cell which is the origin of the sperm production.

30 Jun 2018

Pediatric neuroblastoma patients have high risk of long-term psychological impairment

A new study reveals that pediatric neuroblastoma patients are at elevated risk for long-term psychological impairment. In addition, those who experience such impairment as they get older tend to require special education services and to not go on to college.

11 Jun 2018

New findings point to potential therapeutic avenues for leukemia

Scientists have known for decades that the Hox family of transcription factors are key regulators in the formation of blood cells and the development of leukemia.

9 May 2018

Hippo pathway plays essential role in embryonic development of the mouse heart

Using a technology that provides a 'high-resolution view' of the status of individual cells, a team of researchers has gained new insights into the embryonic development of the mouse heart.

24 Apr 2018

Vitamin A-enriched cattle fodder is the key to protect against cow's milk allergy

A real milk allergy occurs in about three to five percent of European children and more rarely in adults. The disease is different from lactose intolerance, in which a lack of the enzyme lactase results in the inability to properly break down lactose, a sugar found in milk products.

6 Feb 2018

Scientists discover role of two specific HOX genes in colon cancer development

In breakthrough colon cancer research, scientists at Christiana Care Health System's Center for Translational Cancer Research of the Helen F. Graham Cancer Center & Research Institute have discovered that over-expression of HOXA4 and HOXA9 genes in colon cancer stem cells promotes cell replication and contributes to the overpopulation of stem cells that drives colon cancer development.

31 Jan 2018

UCLA scientists coax human stem cells to become sensory interneurons

Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have, for the first time, coaxed human stem cells to become sensory interneurons -- the cells that give us our sense of touch.

11 Jan 2018