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Moderna's updated COVID-19 vaccine for Autumn 2023 outperforms in cost and clinical impact

Moderna's updated mRNA-1273.815 COVID-19 vaccine shows promising results in reducing symptomatic cases, hospitalizations, and deaths in high-risk and older adults in Germany. The study finds the vaccine to be more cost-effective and clinically beneficial than both no vaccination and Pfizer's XBB.1.5 BNT162b2 vaccine.

12 Oct 2023

IL-17: The molecule that could revolutionize autoimmune and cancer treatments

The research paper explores the multifaceted role of the IL-17 family in immune response, covering everything from infection control to pathological conditions like autoimmune diseases and cancer. Future therapies may exploit IL-17's unique signaling pathways to offer more targeted and cost-effective treatments.

12 Oct 2023

Unlocking hope: Promising treatments for cognitive impairment in HIV patients on the horizon

Researchers examine the mechanisms responsible for the increased risk of neurocognitive impairment in HIV patients and explore potential treatments.

12 Oct 2023

Could young blood be the key to reversing age-related cognitive decline?

Researchers at the University of Auckland identify platelet factor 4 (PF4) in young blood as a key player in reversing age-related cognitive decline in mice. The study offers a promising avenue for treating dementia-related conditions and enhancing brain function in aging populations.

11 Oct 2023

Genetically edited chickens show resistance to avian influenza in landmark study

Researchers use CRISPR technology to create chickens resistant to avian influenza, targeting specific genes to inhibit viral replication. The study reveals both the promise and complexities of using genetic editing as a disease control strategy, also shedding light on influenza's adaptability.

11 Oct 2023

Towards xenotransplantation: Genetically altered pig kidneys prove viable in non-human primates

Researchers used a genetically engineered porcine donor to develop kidney grafts.

11 Oct 2023

Exploring the link between drugs and microbiota: a growing imperative in precision medicine

The intricate interactions between gut microbiota and drugs.

11 Oct 2023

Gut defenders: How T-cell intraepithelial lymphocytes guard against colon cancer

In the latest research published in Science Immunology, experts delve into the gene expression patterns of distinct intraepithelial lymphocyte populations in various gastrointestinal tract regions. Key findings reveal the roles of T-cell IELs in detecting infections and ensuring the gut's barrier integrity, with a special emphasis on their function in combating colon cancer.

9 Oct 2023

Amsterdam's H-TEAM initiative on track to eradicate HIV with groundbreaking city-centered approach

Amsterdam's H-TEAM initiative has achieved a significant reduction in HIV infections from 2010 to 2022 using a city-centered approach. By combining treatments, including testing, pre-exposure prophylaxis, and stakeholder collaboration, the city has surpassed the UNAIDS 95-95-95 target and is on track to potentially eliminate HIV entirely in the near future.

9 Oct 2023

Gut's role in gout: New study unravels microbiome's influence on uric acid levels

In a comprehensive study, researchers explored the causal relationship between the gut microbiome, serological urate levels, and gout using Mendelian randomization. The findings reveal that certain genetically predicted gut microbial taxa influence uric acid levels and gout development, and vice versa, suggesting the gut microbiome as a potential therapeutic target for gout.

9 Oct 2023

Breast milk microbiome changes after COVID-19 vaccination, linked to enhanced infant protection

Study explored the association between BNT162b2 vaccine-induced antibodies and the breast milk microbiome in 49 breastfeeding mothers, revealing that post-vaccination alterations in the microbiome were linked to humoral protection against SARS-CoV-2.

9 Oct 2023

Compound found to inhibit influenza virus replication by targeting host enzyme

How can the propagation of influenza viruses be stopped? For a new approach in the therapy of influenza infections, Prof. Hiroki Kato from the Institute of Cardiovascular Immunology at the University Hospital Bonn (UKB) and the Cluster of Excellence ImmunoSensation2 of the University of Bonn receives an Open Philanthropy grant of 2.2 million US dollars.

9 Oct 2023

Immature immune cells near dural sinuses linked to neonatal viral meningoencephalitis

Examine virus propagation within central nervous systems (CNSs) during systemic infection.

9 Oct 2023

Next-gen intranasal vaccine takes on measles, mumps, and multiple COVID-19 variants in one shot

Researchers developed an intranasal trivalent measles-mumps-SARS-CoV-2 vaccine that provides robust protection against multiple coronavirus variants. Leveraging the established measles-mumps-rubella platform, this vaccine demonstrates broad and adaptable immune responses, especially against Delta and Omicron variants.

8 Oct 2023

Antigenic cartography decodes the mysteries of SARS-CoV-2 variants and vaccines

Using antigenic cartography, researchers analyzed cross-reactivity patterns of SARS-CoV-2 variants and the effect of spike-protein changes on post-infection and vaccination immune responses. The study illuminated unique neutralization profiles and underscored the evolving defense mechanisms with repeated immunizations.

8 Oct 2023

Novavax vaccine shows resilient defense against symptomatic COVID-19 despite Omicron challenge

Recent study assesses NVX-CoV2373 vaccine's effectiveness against Omicron variant. Findings show decreased efficacy over four months, but stable protection against symptomatic COVID-19.

8 Oct 2023

Researchers explore immunomodulating targets for improving glioblastoma therapies

Researchers have delved into the intricate heterogeneity of glioblastoma, a notoriously aggressive brain tumor, using advanced single-cell RNA sequencing and innovative zebrafish avatars. Their findings spotlighted the LGALS1 gene's role in immunosuppression and suggested potential therapeutic avenues for personalized GBM treatment.

8 Oct 2023

Protein recombinant vaccine NVX-CoV2373 confers protection during Omicron dominant period in Italy

The NVX-CoV2373 COVID-19 vaccine offers significant protection against symptomatic infections, but its effectiveness against SARS-CoV-2 declines within four months, according to a study in JAMA Network Open using Italian data. However, its protection against symptomatic COVID-19 seems to remain stable during this period.

8 Oct 2023

Study highlights the patient heterogeneity in atopic dermatitis and demonstrates the promises of personalized treatment

Researchers investigated endotype-phenotype associations in atopic dermatitis (AD) beyond its general clinical severity.

4 Oct 2023

Trametinib: Potential therapeutic game-changer for Alzheimer's disease

Researchers developed the ATRIVIEW® platform to screen for molecules that promote differentiation neural stem cells (NSCs).

4 Oct 2023

Ribonucleic Acid News and Research

Moderna's updated COVID-19 vaccine for Autumn 2023 outperforms in cost and clinical impact

IL-17: The molecule that could revolutionize autoimmune and cancer treatments

Unlocking hope: Promising treatments for cognitive impairment in HIV patients on the horizon

Could young blood be the key to reversing age-related cognitive decline?

Genetically edited chickens show resistance to avian influenza in landmark study

Towards xenotransplantation: Genetically altered pig kidneys prove viable in non-human primates

Exploring the link between drugs and microbiota: a growing imperative in precision medicine

Gut defenders: How T-cell intraepithelial lymphocytes guard against colon cancer

Amsterdam's H-TEAM initiative on track to eradicate HIV with groundbreaking city-centered approach

Gut's role in gout: New study unravels microbiome's influence on uric acid levels

Breast milk microbiome changes after COVID-19 vaccination, linked to enhanced infant protection

Compound found to inhibit influenza virus replication by targeting host enzyme

Immature immune cells near dural sinuses linked to neonatal viral meningoencephalitis

Next-gen intranasal vaccine takes on measles, mumps, and multiple COVID-19 variants in one shot

Antigenic cartography decodes the mysteries of SARS-CoV-2 variants and vaccines

Novavax vaccine shows resilient defense against symptomatic COVID-19 despite Omicron challenge

Researchers explore immunomodulating targets for improving glioblastoma therapies

Protein recombinant vaccine NVX-CoV2373 confers protection during Omicron dominant period in Italy

Study highlights the patient heterogeneity in atopic dermatitis and demonstrates the promises of personalized treatment

Trametinib: Potential therapeutic game-changer for Alzheimer's disease

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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