Sanger sequencing News and Research

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New study provides convincing evidence of the essential role of cylicins in sperm development and fertility

Researchers investigated the Role of Cylicins in Spermiogenesis and Male Fertility in Mice and Humans through Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/ CRISPR-associated protein 9 (Cas9) Gene Editing.

30 Nov 2023

New diagnostic workflow improves detection of 5q-spinal muscular atrophy

5q-spinal muscular atrophy (5q-SMA) is one of the more common types of spinal muscular atrophy (SMA) affecting around one in ten thousand individuals worldwide.

15 Nov 2023

How next-gen sequencing is changing antibody drug discovery

New study outlines how next-generation sequencing (NGS) and machine-learning methods can revolutionize antibody discovery, particularly against SARS-CoV-2. The research demonstrates that NGS provides greater epitopic and paratopic diversity, enabling more effective identification and prioritization of therapeutic antibodies.

31 Oct 2023

Genetically edited chickens show resistance to avian influenza in landmark study

Researchers use CRISPR technology to create chickens resistant to avian influenza, targeting specific genes to inhibit viral replication. The study reveals both the promise and complexities of using genetic editing as a disease control strategy, also shedding light on influenza's adaptability.

11 Oct 2023

International report paves way for precision diabetes medicine breakthrough

Precision medicine for prevention, diagnosis, treatment, and prognosis for Diabetes.

9 Oct 2023

Natural antibiotic thiostrepton reveals new hope for inflammatory bowel disease treatment

Researchers explored the therapeutic impact of Thiostrepton on experimental colitis by examining its effects on colon inflammation and determining its targets through various biochemical approaches.

28 Sep 2023

Researchers identify a rare cause of male infertility and discover a potential cure

Researchers investigated the genetic underpinning of asthenozoospermia, the leading cause of male fertility.

18 Sep 2023

Researchers characterize new SARS-CoV-2 BA.2.86 variant neutralization by monoclonal antibodies

Researchers used a SARS-CoV-2 spike protein-pseudotyped viral model to characterize BA.2.86 variant neutralization by monoclonal antibodies.

6 Sep 2023

The first point-of-care genetic test for lactose intolerance: A compact, lab-on-phone diagnostic assay

The performance of a compact diagnostic assay that can accurately and rapidly diagnose lactose intolerance.

4 Sep 2023

Dual CRISPR-Cas3 is a promising tool to induce a gigantic genomic deletion and restore dystrophin protein

Researchers evaluated the use of a dual clustered regularly interspaced short palindromic repeats (CRISPR)-Cas3 system.

29 Aug 2023

The value of whole-exome sequencing as a first-tier genetic test in the diagnosis of skin disorders

The genetic etiology by whole-exome sequencing (WES).

23 Aug 2023

The outcome of invasive S. pyogenes infection is regulated by an interplay between human STING genotype and bacterial NADase activity

The interplay between human STING genotype and bacterial NADase activity.

22 Aug 2023

The contribution of transcription factor ROB1 to the pathophysiology of C. albicans-induced candidal infections

Researchers evaluated the function of the zinc finger transcription factor ROB1 and its two phenotypically distinct alleles in the pathogenesis of Candida albicans infections.

20 Jun 2023

Scientists unlock virus-fighting power with synthetic nanobody platform

Discovery and validation of nanobodies, a promising class of biologics, for viral infection prevention and treatment, including anti-SARS-CoV-2 nanobodies with enhanced neutralization properties through synergistic pairing. The study demonstrates the potential of nanobodies in developing effective therapies against viral infections.

8 Jun 2023

Study identifies two novel highly pathogenic avian influenza viruses (H5N1) clade 2.3.4.4b.2

Researchers investigated the genetic origin, distribution patterns, and antigenicity of novel AIVs.

16 May 2023

The discovery of a novel orthonairovirus from Dermacentor silvarum ticks near the China–North Korea border

Researchers isolated a novel virus of the Orthonairovirus genus.

16 May 2023

A highly efficient platform for detection of SARS-CoV-2 variants

The recent outbreak of the coronavirus disease 2019 (COVID-19) pandemic and the continuous evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have highlighted the significance of new detection methods for global monitoring and prevention.

17 Apr 2023

Sanger sequencing News and Research

New study provides convincing evidence of the essential role of cylicins in sperm development and fertility

New diagnostic workflow improves detection of 5q-spinal muscular atrophy

How next-gen sequencing is changing antibody drug discovery

Genetically edited chickens show resistance to avian influenza in landmark study

International report paves way for precision diabetes medicine breakthrough

Natural antibiotic thiostrepton reveals new hope for inflammatory bowel disease treatment

Researchers identify a rare cause of male infertility and discover a potential cure

Researchers characterize new SARS-CoV-2 BA.2.86 variant neutralization by monoclonal antibodies

The first point-of-care genetic test for lactose intolerance: A compact, lab-on-phone diagnostic assay

Dual CRISPR-Cas3 is a promising tool to induce a gigantic genomic deletion and restore dystrophin protein

The value of whole-exome sequencing as a first-tier genetic test in the diagnosis of skin disorders

The outcome of invasive S. pyogenes infection is regulated by an interplay between human STING genotype and bacterial NADase activity

The contribution of transcription factor ROB1 to the pathophysiology of C. albicans-induced candidal infections

Scientists unlock virus-fighting power with synthetic nanobody platform

Study identifies two novel highly pathogenic avian influenza viruses (H5N1) clade 2.3.4.4b.2

The discovery of a novel orthonairovirus from Dermacentor silvarum ticks near the China–North Korea border

A highly efficient platform for detection of SARS-CoV-2 variants

From Sanger Sequencing to the Human Genome Project: The Evolution of DNA Sequencing Technology

Can poor diet and lifestyle behaviors modify genomic susceptibility to impulsivity?

Study details bacterial agents in 418 ticks extracted from humans in France

Sequencing & Genomics: Elevating Science and Healthcare eBook

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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