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Scientists reveal mechanism underlying cellular degeneration of upper motor neurons

Scientists reveal mechanism underlying cellular degeneration of upper motor neurons

For the first time, scientists have revealed a mechanism underlying the cellular degeneration of upper motor neurons, a small group of neurons in the brain recently shown to play a major role in ALS pathology. [More]
Promising results for stem cell therapy in MS

Promising results for stem cell therapy in MS

Preliminary findings suggest that nonmyeloablative haematopoietic stem cell transplantation may arrest, or even reverse, the progress of disease among patients with relapsing–remitting multiple sclerosis. [More]
Scientists identify new molecular pathway that controls axonal degeneration following injury

Scientists identify new molecular pathway that controls axonal degeneration following injury

Axons connect neurons with each other to form the neural networks that underpin the vital functions of perception, motility, cognition, and memory. In many neurodegenerative disorders, from traumatic injury or toxic damage to diseases such as Alzheimer's or Parkinson's disease, axonal degeneration represents an essential pathological feature. [More]
New discovery may help doctors develop better treatments for brain, spinal cord injuries

New discovery may help doctors develop better treatments for brain, spinal cord injuries

In a discovery that could dramatically affect the treatment of brain and spinal cord injuries, researchers have identified a previously unknown, beneficial immune response that occurs after injury to the central nervous system. [More]
Scientists identify gene that helps regulate development of central nervous system

Scientists identify gene that helps regulate development of central nervous system

Scientists have identified a gene that helps regulate how well nerves of the central nervous system are insulated, researchers at Washington University School of Medicine in St. Louis report. [More]
USC neuroscientists find potential prevention for Alzheimer's disease

USC neuroscientists find potential prevention for Alzheimer's disease

University of Southern California neuroscientists may have unlocked another puzzle to preventing risks that can lead to Alzheimer's disease. Researchers at Keck Medicine of USC used high-resolution imaging of the living human brain to show for the first time that the brain's protective blood barrier becomes leaky with age, starting at the hippocampus, a critical learning and memory center that is damaged by Alzheimer's disease. [More]
New article provides insight into cognitive fatigue in people with multiple sclerosis

New article provides insight into cognitive fatigue in people with multiple sclerosis

Kessler Foundation researchers have authored a new article that provides insight into the factors that contribute to cognitive fatigue in individuals with multiple sclerosis (MS). The article, "Subjective cognitive fatigue in MS depends on task length," was epublished ahead of print on October 27 in Frontiers in Neurology. [More]
Cornell scientists develop new computational method to identify functional human genome

Cornell scientists develop new computational method to identify functional human genome

Striving to unravel and comprehend DNA's biological significance, Cornell University scientists have created a new computational method that can identify positions in the human genome that play a role in the proper functioning of cells, according to a report published Jan. 19 in the journal Nature Genetics. [More]
Two new drug compounds appear to be effective in treating endometriosis

Two new drug compounds appear to be effective in treating endometriosis

Two new drug compounds - one of which has already proven useful in a mouse model of multiple sclerosis - appear to be effective in treating endometriosis, a disorder that, like MS, is driven by estrogen and inflammation, scientists report in Science Translational Medicine. [More]
Study: Stem cell transplantation improves quality of life in patients with relapsing-remitting MS

Study: Stem cell transplantation improves quality of life in patients with relapsing-remitting MS

Results from a preliminary study indicate that among patients with relapsing-remitting multiple sclerosis (MS), treatment with nonmyeloablative hematopoietic stem cell transplantation (low intensity stem cell transplantation) was associated with improvement in measures of disability and quality of life, according to a study in the January 20 issue of JAMA. [More]
Study suggests that common gut microbe may control risk of developing MS

Study suggests that common gut microbe may control risk of developing MS

A common gut microbe might curb the risk of developing multiple sclerosis--at least in women--suggests the largest study of its kind published online in the Journal of Neurology Neurosurgery & Psychiatry. [More]
Researchers reveal link between the microbiome of young mice and later onset of autoimmune disease

Researchers reveal link between the microbiome of young mice and later onset of autoimmune disease

Researchers have revealed that the colonization of the gut of young mice by certain types of bacteria can lead to immune responses later in life that are linked to disease. [More]
CT measures can refine PAH prognosis

CT measures can refine PAH prognosis

Structural features identifiable on computed tomography pulmonary angiography can provide prognostic information for patients with pulmonary arterial hypertension, say UK researchers. [More]
MRIGlobal awarded $54 million NIH contract to provide support for drug development

MRIGlobal awarded $54 million NIH contract to provide support for drug development

MRIGlobal today announced that it has been awarded a $54 million, 10-year program from the National Institute of Neurological Disorders and Stroke to provide support for the development and manufacturing of drug candidates for ultimate use in human clinical trials. [More]
Biogen Idec, Columbia University Medical Center form $30 million genomics research alliance

Biogen Idec, Columbia University Medical Center form $30 million genomics research alliance

Biogen Idec and Columbia University Medical Center have formed a $30 million strategic alliance to conduct genetics discovery research on the underlying causes of disease and to identify new treatment approaches. As part of this agreement, a sequencing and analysis facility and shared postdoctoral program will be established at Columbia to support collaborative genetics studies. [More]
American Migraine Foundation plans to create Migraine Patient Registry and Biorepository

American Migraine Foundation plans to create Migraine Patient Registry and Biorepository

Migraine affects 36 million Americans, can have a major impact on patients' quality of life, and even on their relationships. The World Health Organization estimates that migraine is the third most prevalent medical disorder in the world, the 4th most disabling among women and the 7th most disabling overall. [More]
Study: Synthetic triglyceride oil may provide hope for people with Huntington's disease

Study: Synthetic triglyceride oil may provide hope for people with Huntington's disease

An early study suggests that a synthetic triglyceride oil called triheptanoin may provide hope for people with Huntington's disease. The study is published in the January 7, 2015, online issue of Neurology, the medical journal of the American Academy of Neurology. [More]
Quadrivalent HPV vaccine cleared of multiple sclerosis risk

Quadrivalent HPV vaccine cleared of multiple sclerosis risk

A study of almost 4 million girls and women allays fears that receipt of the quadrivalent human papillomavirus vaccine could increase the risk of developing multiple sclerosis, or other demyelinating disorders. [More]
BrainStorm's phase 2a ALS study meets primary endpoint

BrainStorm's phase 2a ALS study meets primary endpoint

BrainStorm Cell Therapeutics Inc., a leading developer of adult stem cell technologies for neurodegenerative diseases, today announced positive final results from its phase 2a clinical trial of NurOwn™ in amyotrophic lateral sclerosis (ALS) patients, which enrolled 14 subjects at Hadassah Medical Center in Jerusalem. [More]
New findings may lay groundwork of novel treatment for people with Huntington's disease

New findings may lay groundwork of novel treatment for people with Huntington's disease

By adjusting the levels of a key signaling protein, researchers improved motor function and brain abnormalities in experimental animals with a form of Huntington's disease, a severe neurodegenerative disorder. [More]