Simian Immunodeficiency Virus (SIV) News and Research

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Simian immunodeficiency virus (SIV) is a retrovirus that is found, in numerous strains, in primates; the specific strains infecting humans are HIV-1 and HIV-2, the viruses that cause AIDS.

Study assesses protective capabilities of DNA vaccines against SIV

Inovio Biomedical Corporation, a leader in DNA vaccine design, development and delivery, announced today that data generated from a pre-clinical collaborative study by National Cancer Institute (NCI) and Inovio scientists were published in the scientific journal Proceedings of the National Academy of Sciences in a paper entitled: “DNA vaccination in rhesus macaques induces potent immune responses and decreases acute and chronic viremia after SIVmac251 challenge.”

3 Sep 2009

Novel approach for developing an AIDS vaccine

Researchers at the Yerkes National Primate Research Center, Emory University, believe conventional vaccine strategies should not be the only avenue explored in the development of an effective AIDS vaccine.

7 Aug 2009

Vaccine candidate successful in blocking Simian version of HIV

Researchers have successfully blocked SIV, the simian version of HIV, using a new technique that could help lead to the development of an effective HIV/AIDS vaccine, the Children's Hospital of Philadelphia. The team also included scientists from Nationwide Children's Hospital in Columbus, Ohio, and the New England Primate Research Center in Boston.

18 May 2009

Gene transfer technology may lead to an HIV vaccine

A research team may have broken the stubborn impasse that has frustrated the invention of an effective HIV vaccine, by using an approach that bypasses the usual path followed by vaccine developers.

17 May 2009

New HIV drug may help patients not responding to treatment

A potential treatment for HIV may one day help people who are not responding to Anti-Retroviral Therapy, suggests new research published tomorrow in The Journal of Immunology.

1 Apr 2009

Experimental microbicide containing natural compound provides protection in monkeys against simian version of HIV

An experimental microbicide containing a naturally occurring compound provides protection in monkeys against the simian version of HIV by diminishing immune responses to the virus, according to a study published Wednesday in the journal Nature, the Los Angeles Times reports.

5 Mar 2009

Scientists create HIV strain that can infect monkeys

Scientists have created a strain of HIV that is able to infect and multiply in monkeys, leading to the possibility that researchers would be able to test HIV/AIDS drugs and vaccines in monkeys before testing them in humans, according to a study published in the journal Proceedings of the National Academy of Sciences, Reuters UK reports.

4 Mar 2009

A new monkey model for HIV

By altering just one gene in HIV-1, scientists have succeeded in infecting pig-tailed macaque monkeys with a human version of the virus that has until now been impossible to study directly in animals.

2 Mar 2009

Blocking immune receptor molecule improves response to HIV-like virus, prolongs survival in monkeys

By blocking PD-1 (programmed death-1), an immune receptor molecule known to inhibit the immune response to chronic viral infections, scientists have safely and significantly reduced the plasma viral load and also prolonged survival of rhesus macaque monkeys severely infected with simian immunodeficiency virus (SIV), the nonhuman primate version of human immunodeficiency virus (HIV).

10 Dec 2008

Why are so many infectious diseases jumping from animals to humans?

Why do we have so little capacity to predict epidemics, or avoid them? Some answers, and possible solutions, can be found in the first trench-to-bench guide to wild primate infectious diseases, published Nov. 17 in the Yearbook of Physical Anthropology.

18 Nov 2008

T-cell-based strategy for HIV-1 vaccines still viable option

The question of whether or not to continue to pursue the development of T-cell-based HIV-1 vaccines has been a source of controversy following last year's widely publicized failure of the field's most promising candidate, a vaccine developed by Merck known as V520.

10 Nov 2008

FDA approves Energex Systems non-drug therapy for HIV research

Energex Systems, Inc. announced today that it has been granted approval from the Federal Food and Drug Administration (FDA) to utilize its experimental HemoModulation therapy in a clinical trial of HIV infected patients. The purpose of the study will be to demonstrate safety and monitor viral load changes in patients who are not yet eligible for antiviral drug therapy.

14 Jul 2008

New OPAL therapy presents simple, cost-effective method of treating HIV infection

Australian researchers have unveiled a new immunotherapy technique to help prevent the progression from HIV infection to AIDS. Details of the simple, cost-effective technique are published May 2nd in the open-access journal PLoS Pathogens.

2 May 2008

AIDS, an evolutionary accident?

AIDS, a fatal disease in humans, may partly be the consequence of an evolutionary accident, scientists heard at the Society for General Microbiology's 162nd meeting being held this week at the Edinburgh International Conference Centre.

1 Apr 2008

Scientists discover how salmonella becomes lethal for AIDS patients

Nearly half of all HIV-positive African adults who become infected with Salmonella die from what otherwise would be a seven-day bout of diarrhea.

25 Mar 2008

Researchers examine immune cells where HIV can lie dormant, possible treatments

Researchers have determined how HIV is able to lie dormant in certain immune system cells and prevent the cells from self-destructing, according to a study published Thursday online in the journal Retrovirology, the AP/Google.com reports.

4 Feb 2008

Infants with poor intestinal flora often develop eczema

In a healthy intestinal system there is a great variety of natural bacteria.

23 Jan 2008

Acute loss of intestinal CD4+ T cells is not predictive of SIV virulence

A sudden loss of T cells -- white blood cells crucial to the immune system -- is not the trigger for the onset of AIDS, according to a study published in the September 2007 issue of the Journal of Immunology by a team of researchers at Tulane National Primate Research Center.

24 Sep 2007

New insights into the complexity of HIV/AIDS

Three related papers published in the Sept. 1 edition of The Journal of Immunology provide key new insights into the complexity of HIV/AIDS. Don Sodora, Ph.D., a principal investigator in SBRI's Viral Vaccines Program who recently joined SBRI from the University of Texas, Southwestern Medical Center, is senior author on one of three papers that collectively show CD4 T-cell depletion, a critical symptom of AIDS, is likely a part of a multifaceted scenario that triggers disease rather than the only cause.

10 Sep 2007

A challenge to the ancient origin of SIVagm based on African Green Monkey mitochondrial genomes

Monkey viruses related to HIV may have swept across Africa more recently than previously thought, according to new research from The University of Arizona in Tucson.

17 Jul 2007