Single Nucleotide Polymorphisms News and Research

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Scientists manipulate good bacteria using CRISPR systems

New North Carolina State University research shows progress in gathering information on an important – yet difficult to characterize – human gut bacterium called Bifidobacterium, which is used in many probiotics that help maintain healthy microbiomes.

19 Jul 2022

The impact of gene amplification in virus adaptation through intermediate hosts

Researchers assessed the impact of gene amplification on cross-species adaptation.

12 Jul 2022

Studies discover multiple gene variants that contribute to the risk and severity of NAFLD in children

In a pair of overlapping studies, a diverse team of researchers, led by scientists at University of California San Diego School of Medicine, have deepened investigations into the genetic origins of nonalcoholic fatty liver disease (NAFLD) in children, describing multiple gene variants (including some previously unknown) that contribute to the risk of developing NAFLD and gene variants associated with the severity of the liver disease.

27 Jun 2022

"Founder events" that reduced genetic diversity found to be common throughout human history

Human populations have waxed and waned over the millennia, with some cultures exploding and migrating to new areas or new continents, others dropping to such low numbers that their genetic diversity plummeted.

23 Jun 2022

More than 1,000 genes linked to severe COVID-19 identified

Since the start of the coronavirus pandemic, scientists and clinicians have struggled to understand why some people with the infection become seriously ill or die while others have few, if any, symptoms.

15 Jun 2022

Researchers discover specific genetic signals in people who develop severe COVID-19

Researchers from the University of Sheffield and Stanford University in the US have discovered there are specific genetic signals in people who develop severe coronavirus infection.

14 Jun 2022

Study offers recommendations for improving statistical inference in population genomics

The second century Alexandrian astronomer and mathematician Claudius Ptolemy had a grand ambition. Hoping to make sense of the motion of stars and the paths of planets, he published a magisterial treatise on the subject, known as the Almagest.

6 Jun 2022

Genetics and environmental factors contribute to how socioeconomic status shapes the brain architecture

Your education, your job, your income, the neighborhood you live in: Together these factors are considered to represent socioeconomic status (SES) and contribute to a variety of health and social outcomes, from physical and mental health to educational achievement and cognitive capacities.

18 May 2022

Case report: human breast milk from vaccinated woman clears persistent SARS-CoV-2 infection

A new study published in the journal Viruses aimed to report the effects of plasma infusion and then breastmilk ingestion as a therapy for persistent SARS-CoV-2 infection in a patient with a common variable immunodeficiency (CVID) phenotype.

18 May 2022

Worldwide study of diverse populations sheds new light on how genes contribute to type 2 diabetes

Ongoing worldwide research of diverse populations by an international team of scientists, including a University of Massachusetts Amherst genetic epidemiologist, has shed important new light on how genes contribute to type 2 diabetes.

12 May 2022

Research describes how DNA damage can affect neural health and function

A new research paper in the journal EMBO Reports describes how DNA damage can affect neural health and function.

12 May 2022

Scientists investigate the association between walking pace and leucocyte telomere length

In a new study, scientists investigated the association between walking pace and leucocyte telomere length.

5 May 2022

New workflow identifies hidden genetic connections that could improve personalized medicine for IBD

All humans carry genetic variations in their DNA, called Single Nucleotide Polymorphisms (SNPs) that can underlie susceptibility to diseases such as diabetes and cancer.

28 Apr 2022

Drug-resistant mold found to be spreading and infecting susceptible people's lungs

A new study led by Imperial College London finds that drug-resistant mold is spreading from the environment and infecting susceptible people's lungs.

25 Apr 2022

Study evaluates SARS-CoV-2 whole genome data from patients and staff in the VA Northeast Ohio Healthcare System

Researchers surveyed over 360 COVID-19 patients to characterize the SARS-CoV-2 genomic sequence diversity of individual infections.

21 Apr 2022

COVID-19 may affect a group of biochemical reactions called one-carbon metabolism

A new study addresses the relationship between SARS-CoV-2 to the metabolism of one-carbon molecules in the host, suggesting new therapeutic pathways.

13 Apr 2022

Dysregulated retroelements associated with autoimmunity in COVID-19

Researchers investigate potential interactions between retro-elements shared between the human and coronavirus genomes.

12 Apr 2022

Study finds better immunotherapy response in lung cancer patients with genetic variant linked to autoimmune disease

A variant of the CTLA-4 gene associated with autoimmune disease was found to be more frequent in non-small cell lung cancer (NSCLC) patients who experienced an exceptionally high response to anti-PD-1 immunotherapy and higher immune-related side effects than in a comparable cohort of lung cancer patients and healthy individuals, according to data presented during the AACR Annual Meeting 2022, held April 8-13.

10 Apr 2022

The effects of SARS-CoV-2 infection in different ancestry origins from the same region

Researchers examined whether varied allelic frequencies of the HLA gene in people of different ancestral origins were associated with increased susceptibility to SARS-CoV-2 infection and disease severity.

4 Apr 2022

Study investigates whether coinfection with multiple SARS-CoV-2 variants exists in COVID-19 patients

A new study shows that multiple variants of this virus may coinfect the same patient, using both genomic sequencing data and computational models.

30 Mar 2022