Small Intestine News and Research

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Study suggests that gastric bypass should be used with caution to treat extreme obesity

Based on five-year follow-up of patients in a randomized clinical trial, researchers have concluded that gastric bypass is the preferred treatment for extreme obesity. This is despite the fact that it is not as effective in reducing body weight as the so-called duodenal switch.

11 Feb 2015

Researchers use pulsed light to modify lactose protein that causes 10% of milk-related allergies

The researchers have managed to modify a type of lactose protein called β-lactoglobulin artificially by means of a treatment with pulsed light. This protein, which is present in lactose serum, is responsible for approximately 10% of milk-related allergies. As a result of this treatment, milk becomes much more digestible.

4 Feb 2015

Gluten-free diet important for people with celiac disease

You'd never suspect it from the proliferation of gluten-free items on supermarket shelves. Yet only one in approximately 133 people - that's 0.75 percent of the population - has celiac disease, a genetic autoimmune disorder that causes the body to react negatively to the intake of gluten, a protein found in wheat, rye, barley and their derivatives.

29 Jan 2015

Study links lysosomal dysfunction with neonatal intestinal disorders

Neonatal intestinal disorders that prevent infants from getting the nutrients they need may be caused by defects in the lysosomal system that occur before weaning, according to a new Northwestern Medicine study.

28 Jan 2015

New research sheds light on the role of Sox10 protein in Hirschsprung's disease patients

Defects in the protein Sox10, a transcription factor that regulates gene expression, may play a role in the development of post-operative GI dysfunction in Hirschsprung's disease patients, according to new research published in Cellular and Molecular Gastroenterology and Hepatology, the new basic science journal of the American Gastroenterological Association.

16 Jan 2015

Study finds difference between results from IHC and quantitative molecular techniques

The cause of type 1 diabetes remains unknown. Several studies using immunohistochemistry (IHC) have independently reported hyperexpression of human leukocyte antigen (HLA) class I on pancreatic islet cells in young patients with recent-onset type 1 diabetes. Investigators have therefore suggested that HLA hyperexpression may be an important first step in the development of type 1 diabetes.

12 Jan 2015

CHLA scientists grow tissue-engineered small intestine from human cells

A new study by researchers at Children's Hospital Los Angeles has shown that tissue-engineered small intestine grown from human cells replicates key aspects of a functioning human intestine. The tissue-engineered small intestine they developed contains important elements of the mucosal lining and support structures, including the ability to absorb sugars, and even tiny or ultra-structural components like cellular connections.

9 Jan 2015

Johns Hopkins scientists create statistical model to measure proportion of cancer incidence

Scientists from the Johns Hopkins Kimmel Cancer Center have created a statistical model that measures the proportion of cancer incidence, across many tissue types, caused mainly by random mutations that occur when stem cells divide.

2 Jan 2015

Researchers map B cell response to non-gluten proteins of wheat in celiac disease

Researchers at Columbia University Medical Center have found that, in addition to gluten, the immune systems of patients with celiac disease react to specific types of non-gluten protein in wheat. The results were reported online in the Journal of Proteome Research.

16 Dec 2014

New technique could help diagnose cancerous, pre-cancerous conditions

Since the first "catalog" of the normal bacterial makeup of the human body was published in 2012, numerous connections between illness and disturbances in the human microbiota have been found. This week, scientists report yet another: Cancerous tumors in the ascending colon (the part nearest to the small intestine) are characterized by biofilms, which are dense clumps of bacterial cells encased in a self-produced matrix.

14 Dec 2014

Malnutrition predicts long-term survival in elderly patients undergoing Whipple procedure

Malnutrition is an important factor predicting long-term survival in older patients undergoing pancreaticoduodenectomy (PD) (commonly called the Whipple procedure) to treat benign tumors and cysts of the pancreas as well as pancreatitis, according to new study results published in the December issue of the Journal of the American College of Surgeons.

6 Dec 2014

New technique measures antioxidant capacities of citrus juices

The antioxidant activity of citrus juices and other foods is undervalued. A new technique developed by researchers from the University of Granada for measuring this property generates values that are ten times higher than those indicated by current analysis methods. The results suggest that tables on the antioxidant capacities of food products that dieticians and health authorities use must be revised.

5 Dec 2014

Study compares rates of clinically recorded fertility problems in women with and without celiac disease

Women with celiac disease present with fertility problems no more often than women in the general population, according to a new study in Gastroenterology, the official journal of the American Gastroenterological Association.

5 Dec 2014

Researchers warn that Vitamin A deficiency can cause eye problems

Obese patients who have undergone bariatric surgery to shed weight should take the supplements prescribed to them to protect their eyes. Taking in too little Vitamin A, in particular, could in some cases actually cause night blindness, dry eyes, corneal ulcers, and in extreme cases total blindness. This advice comes from Rui Azevedo Guerreiro and Rui Ribeiro of the Centro Hospitalar de Lisboa Central in Portugal, who reviewed what little research there currently is on the occurrence of eye conditions following bariatric surgery.

2 Dec 2014

University of Chicago obtains GFFS certification from Gluten Intolerance Group

The University of Chicago has received certification from the Gluten Intolerance Group's Gluten-Free Food Service (GFFS) Accreditation Program for its medical center and campus food service operations. The designation makes UChicago one of three medical centers in the United States to carry the accreditation, and the only academic institution to do so for both its hospital and campus facilities.

25 Nov 2014

New research may help develop drug for celiac disease

Celiac disease patients suffer from gluten intolerance and must adjust to a life without gluten from food sources like wheat, rye and barley.

20 Nov 2014

IntelliCap electronic oral drug delivery technology wins prestigious European ‘High-Tech Innovation Award’

The IntelliCap electronic oral drug delivery technology, created by medtech innovator Medimetrics, has won a prestigious European ‘High-Tech Innovation Award’ from Accenture, the global management consultancy.

18 Nov 2014

Adding ezetimibe to statin therapy reduces cardiovascular events

More than a decade ago, researchers from Brigham and Women's Hospital demonstrated that a high dose statin, which lowered cholesterol further than a regular dose statin, provided better clinical outcomes. But questions remained about whether further reducing cholesterol would be even more effective in reducing cardiovascular-related events.

18 Nov 2014

World-first transitional pain program aims to stop chronic pain following surgery

A world-first transitional pain program that aims to stop pain from becoming chronic after surgery is being pioneered at Toronto General Hospital, University Health Network.

14 Nov 2014

SQI Diagnostics gets FDA clearance to market Celiac Panel in the US

SQI Diagnostics Inc. today announced that it has received notice that the United States Food and Drug Administration has cleared the Company to market its proprietary Celiac Panel in the United States (US).

8 Nov 2014