Small Molecules News and Research

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Next-gen Mpro inhibitor: Promising new drug candidate against Omicron and other SARS-CoV-2 variants

A recent Nature Signal Transduction and Targeted Therapy journal study demonstrated the potential antiviral activity of a new Mpro inhibitor (SY110) against SARS-CoV-2 Omicron and its sublineages.

21 Mar 2023

Snapping at new biotech breakthroughs with Gator Pro

In this interview, we speak to Subodh Nimkar, Marketing Director at Gator Bio, about their latest technology, Gator Pro which allows for fast, reliable, and high-quality data.

From Gator Bio, Inc. 21 Mar 2023

AI-based design method synthesizes polymers that mimic blood plasma

Most life on Earth is based on polymers of 20 amino acids that have evolved into hundreds of thousands of different, highly specialized proteins. They catalyze reactions, form backbone and muscle and even generate movement.

20 Mar 2023

Newly identified small molecule may help treat people with drug-resistant epilepsy

Researchers at Tufts University School of Medicine and colleagues have identified a small molecule that may help treat people with epilepsy whose condition has become resistant to the benzodiazepine drugs usually used in managing seizures.

15 Mar 2023

Specific enzyme produced in liver cancer cells could turn a molecule into potential anticancer drug

Scientists at the National Institutes of Health and Massachusetts General Hospital in Boston have uncovered a potential new approach against liver cancer that could lead to the development of a new class of anticancer drugs.

14 Mar 2023

Novel culture system for effectively growing large numbers of blood stem cells in the lab

Hematopoietic stem cells (HSCs) are important immature blood cells in bone marrow that can be triggered to develop into any blood cell type.

8 Mar 2023

Gene mutation capable of regulating pain discovered

Pain afflicts at least 1.5 billion people worldwide, and despite the availability of various painkilling drugs, not all forms of pain are treatable.

3 Mar 2023

Exploring the neuroprotective potential of cell-penetrating peptides, extracellular vesicles, and micro ribonucleic acids

In a recent review published in Biomedicines, researchers explored extracellular vesicles (EVs), cell-penetrating peptides (CPPs), and micro ribonucleic acids (miRNAs) as therapies for neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD).

1 Mar 2023

First small molecules designed to stimulate immune cells against neuroblastoma

An MUSC Hollings Cancer Center research team has created what team members believe to be among the first small molecules designed to stimulate immune cells to fight cancer.

28 Feb 2023

Study characterizes N-terminal domain structure of a ubiquitin ligase TRAF6

A team of international scientists has recently characterized the structure of tumor necrosis factor receptor associated factor 6 (TRAF6) N-terminal domain for therapeutic purposes.

28 Feb 2023

Life Sciences Innovator Category Winner 2023

Following a rigorous application process, we are proud to announce that Seda have been selected as the UK Life Sciences Innovator Winner 2023 in the Application, Product & Service Design Category.

From Seda Pharmaceutical Development Services 21 Feb 2023

Protein degradation approach can be used to hit an ‘undruggable’ target against cancer

The protein STAT5 has long been an appealing target against cancer, but after decades of research it was consigned to the "undruggable" category.

15 Feb 2023

Light-based technology could improve cancer diagnostics

Machines are currently learning how to identify cancer cells with the help of manipulated light. This approach may help to take the pressure off our hard-pressed health services and reduce waiting times for anxious patients.

14 Feb 2023

Exploring two small molecules for the disintegration of alpha-synuclein fibrils

In a recent study published in the Proceedings of the National Academy of Sciences, researchers assessed the capability of two small molecules of disintegrating alpha-synuclein fibrils.

13 Feb 2023

Scientists illuminate the mechanisms that prevent p53 activation from triggering cancer cell death

Cancer is a disease driven by gene mutations. These mutated genes in cancer fall into two major categories: tumor suppressors and oncogenes.

13 Feb 2023

Researchers discover small molecules that can lock SARS-CoV-2 spike proteins

The infamous spike proteins on the surface of SARS-CoV-2 help it bind to and enter human cells. Because of their important role in spreading infection, these spike proteins are one of the main targets for COVID-19 vaccines and treatments.

9 Feb 2023

Researchers develop a new method to design peptide antibiotics

Hokkaido University researchers have developed a novel method to design and develop peptide antibiotics in large numbers, which will prove critical to controlling antibiotic resistance.

7 Feb 2023

UT Southwestern research could lead to new ways of controlling gene regulation

UT Southwestern Medical Center researchers have discovered a method cells use to turn genes on and off that involves portions of proteins whose function has long been a mystery.

3 Feb 2023

The relationship between natural plant extracts and SARS-CoV-2

Researchers explored plants as an extensive resource of molecules with potential therapeutic action against SARS-CoV-2 and debunked misconceptions.

3 Feb 2023

Oncodesign Services looks to the future

As Oncodesign evolves into Oncodesign Services and begins its journey as an independent business, CEO Fabrice Viviani explains his hopes and plans for the company’s future.

From Oncodesign Services 3 Feb 2023