Systemic Lupus Erythematosus News and Research

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Systemic lupus erythematosus (SLE) is the form of the disease that most people are referring to when they say "lupus." The word "systemic" means the disease can affect many parts of the body. The symptoms of SLE may be mild or serious. Although SLE usually first affects people between the ages of 15 and 45 years, it can occur in childhood or later in life as well.

Researchers explore single-cell sequencing technologies to understand molecular mechanisms of autoimmune diseases

A new review discussed the applications of single-cell ribonucleic acid sequencing (scRNA-seq) in understanding autoimmune disorders.

17 Oct 2022

Immune-mediated inflammatory diseases following COVID-19

Researchers explore the potential association between SARS-CoV-2 infection and immune-mediated inflammatory diseases.

12 Oct 2022

Review on COVID-19 biomedical waste-derived microplastic toxicity

In a new study, researchers reviewed existing literature on the biomedical waste source, elements, and the recent upsurge of microplastics during the SARS-CoV-2 pandemic.

11 Oct 2022

Study establishes a feasible combination therapeutic strategy for ulcerative colitis

Despite recent advancements in our knowledge of the pathogenic mechanisms of ulcerative colitis, there is still a considerable unmet medical need for the treatment of ulcerative colitis.

29 Sep 2022

Study explores the effect of age-associated B cells on COVID-19 vaccine-induced immunity

In a new study, a team of researchers explored the effect of immune checkpoint blockade (ICB)-induced expansion of age-associated B cells (ABCs) on COVID-19 vaccine-derived humoral immunity in patients with cancer and inborn errors of immunity (IEI).

22 Sep 2022

Patients with autoimmune diseases at greater risk of complications after heart attack

In a recent study published in the Journal of the American Heart Association, researchers assessed midterm and management outcomes of acute myocardial infarction (AMI) among patients with rheumatic immune-mediated inflammatory diseases (IMIDs).

18 Sep 2022

New data analysis approach could help uncover the genetic basis of many diseases

In the era of Big Data, obtaining a huge amount of information is the easy part; knowing what to do with it is another story entirely.

9 Sep 2022

Clinical trial shows efficacy and safety of belimumab in East Asian adults with lupus nephritis

This prespecified subgroup analysis of East Asian adults who participated in a phase 3 clinical trial of belimumab added to standard therapy vs. placebo added to standard therapy for lupus nephritis shows earlier and more sustained improvement in kidney outcomes with the addition of belimumab.

2 Sep 2022

The origins, breadth, and resolution of autoreactivity in severe COVID-19

Researchers assessed naïve B cells and autoreactivity in severe COVID-19.

2 Sep 2022

Study reveals safety and uptake of sotrovimab against severe SARS-CoV-2 infection in England

In a newly released study, researchers explored the sotrovimab uptake for severe COVID-19 prophylaxis and its safety across the community populations in England.

22 Aug 2022

The QCOVID4 algorithm developed using data from the Omicron wave identifies those at highest risk of severe COVID-19 outcomes

A recent article illustrated the derivation and validation of the QCOVID4 risk determination algorithm for predicting COVID-19 hospitalization and death risk in England.

18 Aug 2022

ADAR1 mutation sets off biochemical pathways that produce an organ-damaging autoimmune response

A new study shows how mutation of the ADAR1 gene sets off biochemical pathways that produce an autoimmune response that harms the developing brain and other areas of the body.

2 Aug 2022

UT Southwestern physicians outline the risks of pregnancy in women with rheumatic disease

Pregnant women with active rheumatic disease carry a higher risk of adverse outcomes than the general population including hypertension, preeclampsia, higher cesarean section rate, small for gestational aged infants, preterm delivery, and fetal loss. To

19 Jul 2022

Video game intervention improves attention and executive functioning in patients with lupus

A National Jewish Health led study recently published in Lupus finds that technology through video game-based cognitive therapy improves attention and executive functioning in patients with systemic lupus erythematosus (SLE).

14 Jul 2022

The global succinylation and protein abundance in SARS-CoV-2–infected cells

Researchers assessed the global succinylation of SARS-CoV-2-infected host cells.

14 Jul 2022

Booster dose of SARS-CoV-2 vaccine benefits lupus patients

People with systemic lupus erythematosus, or SLE, who received a "booster" dose of SARS-CoV-2 vaccine after full vaccination are roughly half as likely to have a subsequent "breakthrough" COVID-19 infection, a new study shows.

13 Jul 2022

Novel molecular pathway may explain how stress affects neuropsychiatric lupus

A novel molecular pathway involving cell signaling proteins in the brain may explain how stress affects neuropsychiatric lupus with diffuse neuropsychological manifestations.

11 Jul 2022

The possible immune-mediated mechanisms causing CNS alterations during and post-acute SARS-CoV-2 infection

In a recent review published in Immunity, researchers explored potential mechanisms of neuro-immune pathophysiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

22 Jun 2022

Multidisciplinary medical team needed to provide care for pregnant women with lupus, study says

A study that includes researchers at Hospital for Special Surgery underscores the importance of a multidisciplinary medical team to counsel and provide care for women with systemic lupus erythematosus, the most common form of lupus, who become pregnant.

2 Jun 2022

New HSS study clarifies the clinical manifestations of undifferentiated connective tissue disease

A new study by researchers at Hospital for Special Surgery (HSS) has further clarified the clinical manifestations of undifferentiated connective tissue disease (UCTD).