T Lymphocyte News and Research

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Third BNT162b2 dose elicits more durable immune response than second dose

Researchers evaluated the durability of immune responses post-third dose of the BNT162b2 vaccine against SARS-CoV-2.

9 May 2022

SARS-CoV-2 variants are not evolving to escape from T cell-mediated immunity

In a recent study posted to the bioRxiv* pre-print server, researchers demonstrated that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants did not evolve further to escape from T cell-mediated immunity.

6 May 2022

Evaluating immune protection after third and fourth doses of homologous and heterologous SARS-CoV-2 vaccines among kidney transplant recipients

Researchers evaluated the immune responses after the third and fourth doses of homologous and heterologous mRNA vaccines against COVID-19 in kidney transplant recipients.

4 May 2022

Review aims to deepen the understanding of the role of natural killer cells in COVID-19

In a recent study published in Biomedicines, researchers explored the utility of natural killer (NK) cells in coronavirus disease 2019 (COVID-19).

28 Apr 2022

Improved seroprevalence and antibody response after third COVID-19 vaccination

Researchers evaluated the immunogenicity of a third COVID-19 vaccination in antibody deficient subjects.

8 Apr 2022

Study demonstrates cross-neutralization among SARS-CoV-2 Omicron sublineages

Researchers assessed the cross-neutralization among three sublineages of the SARS-CoV-2 Omicron variant: BA.1, BA.2, and BA.3 sublineages, and an additional strain, USA/WA1-2020 (wild-type) in mice.

5 Apr 2022

Divalent SARS-CoV-2 fusion vaccine found to be effective in mice

Researchers bioengineered a divalent fusion vaccine by combining the immunogenic region of the nucleocapsid protein and the receptor-binding domain of the spike protein of SARS-CoV-2.

30 Mar 2022

Novel SARS-CoV-2 strains found to have low impact on CD8 T lymphocytes

Researchers investigated the impact of mutations in the SARS-CoV-2 variants of interest and variants of concern on the properties of the cluster of differentiation 8 T lymphocytes.

25 Mar 2022

Study explores differentially expressed immune genes for COVID-19 patient stratification

In a new study, researchers determined the transcriptional signatures associated with the severity of COVID-19.

7 Mar 2022

T-cell responses linked with protection from SARS-CoV-2 infection in vaccinated individuals with or without cancer

T-cell responses directed against the receptor-binding domain of the SARS-CoV-2 spike protein were associated with protection from SARS-CoV-2 infection in vaccinated individuals with or without cancer, with lower T-cell responses observed in patients with blood cancers.

18 Feb 2022

Study explores differential immune responses against SARS-CoV-2 in adults and children

A new study revealed that the immune responses against SARS-CoV-2 and the clinical course of COVID-19 differs between children and adults.

17 Feb 2022

A synthesis of evidence sheds light on major immune components and mechanisms involved in COVID-19

New research highlights principal host factors that may explain the immune responses to SARS-CoV-2 and its variants in the context of infection susceptibility, disease severity, and previous immunity.

28 Jan 2022

Omicron infection induces cross-reactive immune responses

New research revealed that vaccine-breakthrough infections might elicit cross-reactive bNAbs against all variants of concern.

31 Dec 2021

Reviewing myocarditis and pericarditis in immunosuppressed individuals following COVID-19 mRNA vaccination

A new study did not conclusively correlate the incidence of myocarditis or pericarditis with mRNA vaccination against SARS-CoV-2.

30 Dec 2021

Review of COVID-19 clinical and viral characteristics, pathogenesis, and genetics

A new review article investigates the clinical and viral characteristics, pathogenesis, as well as human genetic basis associated with COVID-19.

27 Sep 2021

Development of SARS-CoV-2 antibody escape variants in an immunocompromised individual

A new study published in mBio discusses the microevolution of SARS-CoV-2.

31 Aug 2021

Researchers study the role of low-density granulocytes in COVID-19

Information on granulocytes helps to understand mechanisms associated with covid-19 and other infectious diseases. Such information also promotes the development of better diagnostic methods and therapies.

30 Aug 2021

Cytokine APRIL plays a protective role against formation of atherosclerotic plaques

Heart attacks and strokes are the main causes of death and loss of productive years globally. These clinical complications are caused by atherosclerosis, which is a chronic disease that leads to the accumulation of LDL cholesterol and immune cells in the inner layer of arteries and thereby resulting in the build-up of atherosclerotic plaques.

26 Aug 2021

MSK researchers identify potential biomarker of response to checkpoint immunotherapy

In recent years, immune-based treatments for cancer have buoyed the hopes of doctors and patients alike. Drugs called immune checkpoint inhibitors have provided lifesaving benefits to a growing list of people with several types of cancer, including melanoma, lung cancer, bladder cancer, and many more.

25 Aug 2021

Glycyrrhizic acid as a drug candidate for COVID-19

A new study presents the benefits of licorice, an age-old herbal remedy, to treat COVID-19 at all stages.

24 Aug 2021