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High blood levels of TMAO predicts chronic kidney disease risk in future

New findings from Cleveland Clinic and Tufts University researchers show high blood levels of TMAO (trimethylamine N-oxide) predicts future risk of developing chronic kidney disease over time.

9 Apr 2024

Study reveals inflammation's role in long COVID's lingering effects

Large-scale study found that long COVID patients exhibit sustained inflammation and specific immune responses associated with varying symptoms, highlighting the importance of personalized treatment approaches.

9 Apr 2024

Researchers find new clues to understanding the progression of primary membranous nephropathy

No therapies currently exist that can halt the progression of chronic kidney disease in children or restore the ability of kidney cells to filter blood.

9 Apr 2024

Rogue immune cell found to cause poor antibody responses in chronic viral infections

Australian researchers have discovered a previously unknown rogue immune cell that can cause poor antibody responses in chronic viral infections.

9 Apr 2024

Pregnancy speeds up biological aging in women, study suggests

Pregnancy may carry a cost, reports a new study from the Columbia University Mailman School of Public Health.

8 Apr 2024

Personalized anti-tumor vaccine enhances immunotherapy for liver cancer

Adding a personalized anti-tumor vaccine to standard immunotherapy is safe and about twice as likely to shrink cancer as standard immunotherapy alone for patients with hepatocellular carcinoma, the most common type of liver cancer, according to a clinical trial led by researchers at the Johns Hopkins Kimmel Cancer Center and its Convergence Institute.

8 Apr 2024

Treating early-stage heart failure in diabetic patients: Insights from ARISE-HF trial

One of the first studies to attempt to treat early-stage heart failure in patients with Type 2 diabetes did not meet its primary endpoint, but a preplanned subgroup analysis found a statistically significant effect of treatment in patients who were not taking SGLT2 inhibitors or GLP-1 RAs, which are antidiabetic medications that also have benefits for the heart.

8 Apr 2024

Novel therapeutic approach identified for overcoming resistance in B-cell leukemia

Despite having an overall survival rate of 94%, B-cell acute lymphoblastic leukemia (B-ALL), the most common childhood cancer, can prove challenging to treat, with survival among relapsed or resistant cases falling between 30-50%.

8 Apr 2024

Lerodalcibep reduces LDL cholesterol by over 50% in high-risk patients

Among patients at high or very high risk for a heart attack or stroke, the addition of the investigational drug lerodalcibep to standard cholesterol-lowering medication for one year reduced LDL, or "bad" cholesterol, levels by more than half on average, compared with a placebo.

8 Apr 2024

Language model uses powers of semantic representation to design more effective mRNA vaccines

The same class of artificial intelligence that made headlines coding software and passing the bar exam has learned to read a different kind of text -; the genetic code.

5 Apr 2024

New method to evaluate enzymes opens path to ferroptosis-targeting cancer drugs

New research could pave the way to develop cancer drugs targeting an enzyme that inhibits ferroptosis, a type of cell death.

5 Apr 2024

Lancet Commission predicts sharp increase in global prostate cancer cases

Cases of prostate cancer are projected to double from 1.4 million per year in 2020 to 2.9 million per year by 2040, with low- and middle-income countries (LMICs) predicted to see the highest increases in cases, according to The Lancet Commission on prostate cancer which will be launched by a presentation at the European Association of Urology Congress.

4 Apr 2024

Using brain organoids to unlock TBI's link to dementia and ALS

A traumatic brain injury (TBI) can quadruple your risk for developing dementia and increase your chances of developing neurodegenerative diseases such as ALS.

4 Apr 2024

Understanding T. cruzi infection and Chagas disease through studies in dogs

Announcing a new article publication for Zoonoses journal. Trypanosoma cruzi, the protozoan parasite and cause of Chagas disease, is widely distributed in many vertebrate and triatomine species throughout North, Central, and South America.

4 Apr 2024

Innovative approach to disrupt misfolding of tau proteins in neurodegenerative diseases

A spectrum of neurodegenerative diseases, including frontotemporal dementia (FTD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are due to the accumulation of abnormal, misfolded tau proteins in the brain.

3 Apr 2024

Lurie Children's Hospital administers first gene therapy for Duchenne muscular dystrophy in Illinois

On March 27, 2024, Ann & Robert H. Lurie Children's Hospital of Chicago treated its first patient with ELEVIDYS (delandistrogene moxeparvovec-rokl), the first gene therapy for Duchenne muscular dystrophy – a rare, genetic disease characterized by progressive muscle damage and weakness.

3 Apr 2024

Certain gut bacteria may help lower cholesterol and heart disease risk

Changes in the gut microbiome have been implicated in a range of diseases including type 2 diabetes, obesity, and inflammatory bowel disease.

2 Apr 2024

New technique reveals insights into gut cell dynamics during inflammation

Cells within the intestines perform various roles including nutrient absorption, sensing, and maintaining homeostasis.

2 Apr 2024

An ActRIIA fusion protein got FDA approved for PAH treatment

On March 26th, the US FDA granted approval for Merck’s WINREVAIR™ (sotatercept-csrk), marking a significant milestone in pulmonary arterial hypertension (PAH) treatment. PAH, characterized by elevated blood pressure in the arteries connecting the heart and lungs, poses a grave risk of heart failure.

From Sino Biological Inc. 28 Mar 2024

Study reveals crucial insights into the ocular effects of Zika virus infection during pregnancy

A groundbreaking study published in the journal iScience presents crucial insights into the ocular effects of Zika virus infection during pregnancy and offers promising avenues for therapeutic intervention.

28 Mar 2024

Therapeutics News and Research

High blood levels of TMAO predicts chronic kidney disease risk in future

Study reveals inflammation's role in long COVID's lingering effects

Researchers find new clues to understanding the progression of primary membranous nephropathy

Rogue immune cell found to cause poor antibody responses in chronic viral infections

Pregnancy speeds up biological aging in women, study suggests

Personalized anti-tumor vaccine enhances immunotherapy for liver cancer

Treating early-stage heart failure in diabetic patients: Insights from ARISE-HF trial

Novel therapeutic approach identified for overcoming resistance in B-cell leukemia

Lerodalcibep reduces LDL cholesterol by over 50% in high-risk patients

Language model uses powers of semantic representation to design more effective mRNA vaccines

New method to evaluate enzymes opens path to ferroptosis-targeting cancer drugs

Lancet Commission predicts sharp increase in global prostate cancer cases

Using brain organoids to unlock TBI's link to dementia and ALS

Understanding T. cruzi infection and Chagas disease through studies in dogs

Innovative approach to disrupt misfolding of tau proteins in neurodegenerative diseases

Lurie Children's Hospital administers first gene therapy for Duchenne muscular dystrophy in Illinois

Certain gut bacteria may help lower cholesterol and heart disease risk

New technique reveals insights into gut cell dynamics during inflammation

An ActRIIA fusion protein got FDA approved for PAH treatment

Study reveals crucial insights into the ocular effects of Zika virus infection during pregnancy

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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