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Biomedical engineers grow 3D human heart muscle that acts just like natural tissue

Duke University biomedical engineers have grown three-dimensional human heart muscle that acts just like natural tissue. This advancement could be important in treating heart attack patients or in serving as a platform for testing new heart disease medicines.

7 May 2013

Targacept reports net loss of $8.1 million in first quarter 2013

Targacept, Inc., a clinical-stage biopharmaceutical company developing novel NNR Therapeutics™, today reported its financial results for the first quarter ended March 31, 2013.

7 May 2013

Aileron Therapeutics concludes first-in-human study of ALRN-5281 Stapled Peptide drug

Aileron Therapeutics, Inc. today announced the completion of the first-in-human study of its lead Stapled Peptide drug, ALRN-5281, a proprietary, long-acting growth-hormone-releasing hormone (GHRH) agonist for treating orphan endocrine disorders, including adult growth hormone (GH) deficiency and human immunodeficiency virus (HIV) lipodystrophy, as well as broader patient populations involving a wide variety of metabolic/endocrine diseases.

7 May 2013

Entremed reports patent issuance for its lead drug candidate ENMD-2076

EntreMed, Inc., a clinical-stage pharmaceutical company developing therapeutics for the treatment of a variety of cancers, today announced the issuance by the Chinese State Intellectual Property Office of Patent Certificate No. ZL 200680044656.7.

7 May 2013

Neuroperspective reviews status and prospects of therapeutics for Parkinson's disease

NI Research, the leading publisher of independent research on the neurotherapeutics industry, has released the May issue of NeuroPerspective, which reviews the status and prospects of therapeutics for Parkinson's.

7 May 2013

Researchers explore biological processes of stem cell division

The human body contains trillions of cells, all derived from a single cell, or zygote, made by the fusion of an egg and a sperm. That single cell contains all the genetic information needed to develop into a human, and passes identical copies of that information to each new cell as it divides into the many diverse types of cells that make up a complex organism like a human being.

6 May 2013

Novel screening method for identifying inhibitors of EZH2 methyltransferase

Tumor repressor genes, which inhibit tumor formation, can be "turned off" due to undesirable molecular changes affecting the chromosomes on which the genes reside. Understanding and being able to control these alterations could lead to new approaches for activating or inactivating genes linked to cancer.

5 May 2013

EntreMed announces issuance of patent for clinical-stage compound, 2-methoxyestradiol

EntreMed, Inc., a clinical-stage pharmaceutical company developing therapeutics for the treatment of a variety of cancers, announced the issuance of a U.S. patent covering methods of treatment and formulations for its clinical-stage compound, 2-methoxyestradiol.

3 May 2013

TSRI scientists find dissimilar genes that keep very similar shapes

Solving the structure of a critical human molecule involved in cancer, scientists at The Scripps Research Institute have found what they call a good example of structural conservation-dissimilar genes that keep very similar shapes.

2 May 2013

Scientists study repeating patterns in nature to better understand role of immune system in cancer

Can the patterns in tree branches or the meandering bends in a river provide clues that could lead to better cancer therapies? According to a new study from Virginia Commonwealth University Massey Cancer Center, these self-similar, repeating patterns in nature known as fractals help scientists better understand how the immune system is organized and may one day be used to help improve stem cell transplant outcomes in leukemia patients by predicting the probability of transplant complications.

2 May 2013

Findings set the stage for identifying potential new drug targets, treatment strategies for AML

nvestigators for The Cancer Genome Atlas Research Network have detailed and broadly classified the genomic alterations that frequently underlie the development of acute myeloid leukemia, a deadly cancer of the blood and bone marrow.

2 May 2013

Details about genomic landscapes of AML and endometrial cancer revealed

Two studies from The Cancer Genome Atlas program reveal details about the genomic landscapes of acute myeloid leukemia and endometrial cancer.

2 May 2013

Clinical study shows association between results of ChemoFx and RFS of cervical cancer patients

A clinical study reporting an association between the results of the ChemoFx chemoresponse assay and recurrence free survival of cervical cancer patients has been accepted for publication by Gynecologic Oncology.

30 Apr 2013

Glide Pharma awarded contract from Pfenex Inc. to develop a solid formulation of recombinant anthrax vaccine

Glide Pharma® today announced the award of a sub-contract from Pfenex Inc. to develop a solid formulation containing the recombinant Protective Antigen (rPA) from Bacillus anthracis expressed in Pfēnex Expression Technology™ suitable for delivery with the Glide SDI® (solid dose injector). This approach will address two important logistical constraints of the currently available vaccine, namely, long term stability during storage and ease of administration.

30 Apr 2013

Drug alerts have variable impact on prescribing habits

Direct communication with healthcare professionals, in the form of so-called “Dear doctor” letters, can be effective in reducing inappropriate and unsafe use of medicines, Dutch scientists believe.

29 Apr 2013

Maruishi gains exclusive rights to develop, commercialize Cara Therapeutics' CR845 in Japan

Cara Therapeutics, Inc. and Maruishi Pharmaceutical Company, Ltd. today announced that they have entered into a License Agreement providing Maruishi with exclusive rights to develop, manufacture and commercialize Cara's lead analgesic drug candidate, CR845, for acute pain and uremic pruritus in Japan.

29 Apr 2013

Therapeutics News and Research

Biomedical engineers grow 3D human heart muscle that acts just like natural tissue

Targacept reports net loss of $8.1 million in first quarter 2013

Aileron Therapeutics concludes first-in-human study of ALRN-5281 Stapled Peptide drug

Entremed reports patent issuance for its lead drug candidate ENMD-2076

Neuroperspective reviews status and prospects of therapeutics for Parkinson's disease

Researchers explore biological processes of stem cell division

Novel screening method for identifying inhibitors of EZH2 methyltransferase

EntreMed announces issuance of patent for clinical-stage compound, 2-methoxyestradiol

TSRI scientists find dissimilar genes that keep very similar shapes

Scientists study repeating patterns in nature to better understand role of immune system in cancer

Findings set the stage for identifying potential new drug targets, treatment strategies for AML

Details about genomic landscapes of AML and endometrial cancer revealed

Clinical study shows association between results of ChemoFx and RFS of cervical cancer patients

Glide Pharma awarded contract from Pfenex Inc. to develop a solid formulation of recombinant anthrax vaccine

Drug alerts have variable impact on prescribing habits

Maruishi gains exclusive rights to develop, commercialize Cara Therapeutics' CR845 in Japan

BioLineRx starts enrollment in Phase I/II trial of BL-8020 for treatment of HCV

Opsona raises €33M in oversubscribed financing round

Researchers identify how proteasome takes care of unwanted, potentially toxic proteins

Researchers create "designer" tracer for earlier diagnosis and better treatments of Alzheimer's

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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