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Novel brain organoid model unveils link between inflammation and astrocyte dysfunction

The brain is typically depicted as a complex web of neurons sending and receiving messages. But neurons only make up half of the human brain.

28 Feb 2024

Using machine learning to identify key predictors of mortality in dementia patients

Researchers at the Icahn School of Medicine at Mount Sinai and others have harnessed the power of machine learning to identify key predictors of mortality in dementia patients.

28 Feb 2024

Bariatric surgery outperforms medical management in long-term diabetes control

People with type 2 diabetes who underwent bariatric surgery achieved much better long-term blood glucose control compared to people who received medical management plus lifestyle interventions, according to a new study published in JAMA, or Journal of the American Medical Association, and funded by the National institute of Diabetes, Digestive and Kidney Diseases, part of The National Institutes of Health.

27 Feb 2024

UMSOM wins $3.5 million BARDA contract to develop animals models for radiation research

University of Maryland School of Medicine Dean Mark T. Gladwin, MD, announced today that UMSOM faculty scientists have been selected as key contractors by the Biomedical Advanced Research and Development Authority (BARDA), for the federal agency's Radiation Nuclear Animal Model Development program.

26 Feb 2024

Boston College biologist wins NIH grant to study viral insulins for cancer treatment

Boston College Assistant Professor of Biology Emrah Altindis has been awarded a five-year, $2.5-million grant from the National Institutes of Health to study viral insulins and mechanisms related to IGF-1 receptor protein inhibition and its potential applications in cancer treatment.

26 Feb 2024

Using deep brain stimulation to map dysfunctional brain circuits linked to four disorders

Mass General Brigham researchers identified sets of connections that are disrupted and malfunctioning as a consequence of Parkinson’s disease, dystonia, obsessive compulsive disorder and Tourette's syndrome.

24 Feb 2024

Yale School of Medicine secures $575,000 grant for Long COVID research

Yale School of Medicine and its Center for Infection & Immunity (CII) are receiving a $575,000 grant from PolyBio Research Foundation to fund Long COVID research.

23 Feb 2024

Automated insulin delivery systems: Advancements and future prospects

A special 13-article supplement to the peer-reviewed journal Diabetes Technology & Therapeutics (DTT) examines the "Development and Future of Automated Insulin Delivery (AID) Systems.

23 Feb 2024

Off-the-shelf cancer vaccine shows promising results in patients with KRAS-mutated tumors

Samara Rahman, 74, considers herself lucky. She gets to take walks on the beach, go swimming and ride her bike -; all things that were taken from her when she was diagnosed with pancreatic cancer in November of 2022.

22 Feb 2024

Mapping the human dysfunctome with deep brain stimulation

A new study led by investigators from Mass General Brigham demonstrated the use of deep brain stimulation (DBS) to map a 'human dysfunctome' -; a collection of dysfunctional brain circuits associated with different disorders.

22 Feb 2024

Natural killer cells lead the charge in cancer treatment innovation

Review synthesizes research on NK cells' role in cancer immunity and their potential in therapeutics through bioengineering, immune checkpoint inhibitors, and cell engagers, highlighting ongoing preclinical and clinical trials.

22 Feb 2024

New immunotherapy target activin receptor 1C shows promise against cancer

Drugs that target a receptor on immune cells called activin receptor 1C may combat tumor-induced immune suppression and help patients' immune systems fight back against cancer, according to a study by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.

22 Feb 2024

MD Anderson acquires cell therapy safety technology from Bellicum Pharmaceuticals

The University of Texas MD Anderson Cancer Center today announced it has acquired certain assets from Bellicum Pharmaceuticals, Inc. related to the CaspaCIDe switch platform and the GoCAR platform.

22 Feb 2024

Simple blood test to detect Alzheimer's disease may replace more invasive diagnostic methods

A simple blood test to diagnose Alzheimer's disease soon may replace more invasive and expensive screening methods such as spinal taps and brain scans.

22 Feb 2024

Selkirk Pharma announces new APS qualified facility with advanced fill/finish capacity in Spokane, WA

Selkirk Pharma, Inc., a privately held U.S. pharmaceutical manufacturer specializing in the fill and finish of injectable drugs, including vaccines and biological therapeutics, today announced the Aseptic Process Simulation (APS) qualification of its sterile manufacturing facility and newly available fill/finish capacity.

From Selkirk Pharma 22 Feb 2024

Novel treatment for polycythemia vera shows promise in clinical trial

A novel treatment for polycythemia vera, a potentially fatal blood cancer, demonstrated the ability to control overproduction of red blood cells, the hallmark of this malignancy and many of its debilitating symptoms in a multi-center clinical trial led by the Icahn School of Medicine at Mount Sinai.

21 Feb 2024

Collaborative project gets $20 million to develop new radiopharmaceutical cancer therapies

UT Health Science Center researchers Gabor Tigyi, MD, PhD, Harriet Van Vleet Endowment Professor in Basic Oncology Research, Junming Yue, PhD, associate professor in the Department of Pathology, Sue Chin Lee, PhD, in the Department of Physiology, and David Schwartz, MD, chair of the Department of Radiation Oncology, are part of a scientific leadership group awarded $20 million from the University of Tennessee-Oak Ridge Innovation Institute in partnership with Oak Ridge National Laboratory and the University of Tennessee, Knoxville, to develop new radiopharmaceutical therapies to treat cancer.

21 Feb 2024

Therapeutics News and Research

Novel brain organoid model unveils link between inflammation and astrocyte dysfunction

Using machine learning to identify key predictors of mortality in dementia patients

Bariatric surgery outperforms medical management in long-term diabetes control

UMSOM wins $3.5 million BARDA contract to develop animals models for radiation research

Boston College biologist wins NIH grant to study viral insulins for cancer treatment

Using deep brain stimulation to map dysfunctional brain circuits linked to four disorders

Yale School of Medicine secures $575,000 grant for Long COVID research

Automated insulin delivery systems: Advancements and future prospects

Off-the-shelf cancer vaccine shows promising results in patients with KRAS-mutated tumors

Mapping the human dysfunctome with deep brain stimulation

Natural killer cells lead the charge in cancer treatment innovation

New immunotherapy target activin receptor 1C shows promise against cancer

MD Anderson acquires cell therapy safety technology from Bellicum Pharmaceuticals

Simple blood test to detect Alzheimer's disease may replace more invasive diagnostic methods

Selkirk Pharma announces new APS qualified facility with advanced fill/finish capacity in Spokane, WA

Novel treatment for polycythemia vera shows promise in clinical trial

Collaborative project gets $20 million to develop new radiopharmaceutical cancer therapies

NIH grant boosts research on biofilm dispersal in wound infections

ESMO Congress 2024: Shaping the future of anticancer therapies

Pioneering cell-based treatment for melanoma offered at Siteman Cancer Center

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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