Thrombocytopenia News and Research

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Thrombocytopenia is a condition in which there is a lower-than-normal number of platelets in the blood. It may result in easy bruising and excessive bleeding from wounds or bleeding in mucous membranes and other tissues.

Better clinical outcomes in COVID-19 and vaccine-related myocarditis than classic myocarditis in children

Researchers have investigated the differences between 'classic' myocarditis, COVID-19 induced myocarditis, and vaccine-related myocarditis.

11 Oct 2021

Characterization of circulating neutrophils from hospitalized COVID-19 patients

A new preprint deals with the characterization of neutrophil phenotypes in an attempt to provide biomarkers that can predict severe disease in patients hospitalized with COVID-19.

8 Oct 2021

AstraZeneca COVID-19 vaccine safe and effective in phase 3 U.S., Chile, and Peru trial

A new study reports on the results of phase III clinical trial on the safety and efficacy of the AstraZeneca-Oxford COVID-19 vaccine.

5 Oct 2021

Survey: Over half of chronic liver disease patients had procedures cancelled or delayed due to COVID-19

The results of a new patient survey by the British Liver Trust reveal that over half of chronic liver disease patients say they’ve had procedures cancelled or delayed due to the COVID-19 pandemic.

24 Sep 2021

Blood clot risks are high following SARS-CoV-2 infection, not vaccination

Researchers from the University of Oxford have today announced the results of a study into thrombocytopenia (a condition with low platelet counts) and thromboembolic events (blood clots) following vaccination for Covid-19, some of the same events which have led to restricted use of the Oxford-AstraZeneca vaccine in a number of countries.

15 Sep 2021

Combination of chemotherapy and immune checkpoint inhibitors shows promise in NSCLC patients with untreated brain metastases

Treatment with atezolizumab plus carboplatin and pemetrexed was safe and yielded promising brain progression-free survival in patients with nonsquamous non-small cell lung cancer with untreated and asymptomatic brain metastases.

12 Sep 2021

V-safe: How everyday people help the CDC track covid vaccine safety with their phones

Of the 203 million people who have received at least one dose of a covid-19 vaccine, more than 9 million have enrolled in a program to share information about their health since getting the shot.

7 Sep 2021

COVID-19 presents a higher risk of blood clots than vaccination

The current study found that people were at a slightly higher than normal risk of blood clots after receiving Oxford-AstraZeneca and Pfizer vaccines.

6 Sep 2021

Large Israeli study offers detailed look at safety profile of mRNA vaccine against SARS-CoV-2

A deep look into a nationwide mass vaccination setting in Israel revealed that the BNT162b2 (Pfizer–BioNTech) vaccine is not linked with an elevated risk of a majority of the adverse events under study, with the exception of myocarditis. However, even that potentially severe adverse event is much more pervasive following the infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), found a new study published in the New England Journal of Medicine (NEJM).

30 Aug 2021

Assessing the risks of thrombotic events post vaccination with ChAdOx1 and BNT162b2 vaccines in England

Researchers aim to better understand the population-level thrombotic risks post COVID-19 vaccination with both the ChAdOx1-S and BNT162b2 vaccines.

29 Aug 2021

Persistence of Anti-PF4 levels in VITT patients four months after AstraZeneca COVID-19 vaccine

A study published on medRxiv* preprint server reported the over-time changes in the ability of the serum to activate platelets in vitro.

25 Aug 2021

SARS-CoV-2 Spike may trigger production of antibodies that cross-react with human thrombopoietin to induce thrombocytopenia

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infected individuals often suffer from thrombocytopenia, a condition associated with low platelet counts. The cytokine thrombopoietin regulates platelet count. Previous studies have reported that thrombocytopenia can increase the coronavirus disease 2019 (COVID-19) mortality rate by about five times.

16 Aug 2021

Iron chelating properties of eltrombopag in pediatric acute myeloid leukemia

Oncotarget published "Eltrombopag and its iron chelating properties in pediatric acute myeloid leukemia" which reported that the standard treatment for pediatric AML currently consists in a combination of cytarabine and antracycline.

9 Aug 2021

Risk of venous thrombosis is higher in SARS-CoV-2 infection than vaccination

A study has revealed that adenovirus vector and mRNA-COVID-19 vaccines are associated with an increased risk of thromboembolism and thrombocytopenia.

1 Aug 2021

How SARS-CoV-2 vaccination symptoms differ from early COVID-19 symptoms

A new study published on the preprint server medRxiv* presents an analysis of the differences between recorded vaccination side effects vs. early COVID-19 symptoms. The researchers focused on four vaccines, namely, Pfizer-BioNTech (PB) mRNA (BNT162b2) vaccine, based on messenger ribonucleic acid encoding the viral spike protein; the Moderna mRNA (mRNA-1273) vaccine; the Oxford-AstraZeneca (O-AZ) adenovirus-vectored vaccine; and the Janssen adenovirus-vectored Ad26.COV2.S).

26 Jul 2021

Review details clinical signs of SARS-CoV-2 infection in domestic and wild cats

Now, a new systematic review has been published in the journal Animals that focuses on the clinical symptoms in felines diagnosed with SARS-CoV-2 worldwide.

13 Jul 2021

Striking increase in SARS-CoV-2 antibodies seen with prime dose AstraZeneca vaccine followed by Pfizer-BioNTech

Researchers in Germany have provided evidence that a booster shot of a messenger RNA (mRNA)-based coronavirus disease 2019 (COVID-19) vaccine following prime immunization with AstraZeneca’s adenoviral vector-based vaccine is sufficient to achieve high levels of neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

8 Jul 2021

Researchers discover how vaccine-induced immune thrombotic thrombocytopenia happens

A McMaster University team of researchers recently discovered how, exactly, the COVID-19 vaccines that use adenovirus vectors trigger a rare but sometimes fatal blood clotting reaction called vaccine-induced immune thrombotic thrombocytopenia or VITT.

7 Jul 2021

Early testing can help mitigate blood clots related to AstraZeneca/Oxford vaccine

New research has shown that early testing for blood clots in patients who had received the AstraZeneca/Oxford vaccine led to them being treated successfully, highlighting the need for heightened awareness of the risk among doctors.

29 Jun 2021

Is COVID-19 more severe in pregnancy?

A new study, released as a preprint on the medRxiv* server, indicates that pregnant women are more likely to develop severe disease following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

24 Jun 2021