Thrombus News and Research

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A blood clot or thrombus, is the final product of the blood coagulation step in hemostasis. It is achieved via the aggregation of platelets that form a platelet plug, and the activation of the humoral coagulation system (i.e. clotting factors).

RedHill provides opaganib treatment under compassionate use exemption for Swiss COVID-19 patients

RedHill Biopharma Ltd., a specialty biopharmaceutical company, today announced that it has acted on a request to provide opaganib treatment on an outpatient basis under compassionate use exemption for several Swiss patients suffering from COVID-19 pneumonia.

22 Mar 2021

Study reveals novel approach to reduce the risk of thrombosis by using IgM antibodies

Thrombotic occlusion of blood vessels, which leads to myocardial infarctions, strokes and venous thromboembolisms, is the major cause of death in the western hemisphere.

9 Mar 2021

DSMB recommends continuation of Phase 2/3 study of opaganib for severe COVID-19

RedHill Biopharma Ltd., a specialty biopharmaceutical company, today announced that the independent Data Safety Monitoring Board (DSMB) for the global Phase 2/3 study of opaganib in patients with severe COVID-19, unanimously recommended to continue the study following a pre-scheduled futility review of unblinded efficacy data from the first 135 patients treated in the study and safety data from the first 175 patients.

30 Jan 2021

Scientists engineer potent trivalent inhibitors of thrombin

Thrombosis, the clogging of blood vessels, is a major cause of heart attacks and embolism. Scientists have now engineered the first inhibitors of thrombin, a protease promoting thrombosis, that is three-fold efficient.

29 Jan 2021

Inhibition of blood clotting factor reduces the formation of brain metastases in mice

Brain metastases can only develop if cancer cells first exit the fine blood vessels and enter into the brain tissue.

5 Jan 2021

RedHill Biopharma announces promising preliminary results from opaganib study

TEL AVIV, Israel and RALEIGH, NC, December 15, 2020, RedHill Biopharma Ltd., a specialty biopharmaceutical company, today announced promising preliminary results from a preclinical study with opaganib.

15 Dec 2020

Aprotinin inhibits SARS-CoV-2 entry and replication in cells cultures

Researchers at the University of Kent in the UK and the Hannover Medical School and Goethe University in Germany have observed that the protease inhibitor aprotinin can inhibit viral replication by preventing SARS-CoV-2 entry into host cells.

24 Nov 2020

Pathways contributing to hypercoagulability in severe SARS‐CoV‐2 patients

In a study by researchers explored the possible mechanisms of the clotting disorder, focusing on the role of hypoxia-related activation of coagulation factors; cytokine storm, activation of neutrophils, and the release of neutrophil extracellular traps.

11 Oct 2020

Researchers provide unique experiment for creating artificial tissue-engineered vascular graft

Researchers from St. Petersburg provided a unique experiment. They implanted a polymer scaffold as a vascular prosthesis into the rat abdominal aorta and monitored the process of its bioresobtion for 16 months. An artificial vessel was formed where the scaffold was located.

9 Oct 2020

Study identifies effective treatment for severe COVID-19 patients

As countries around the world race to develop a vaccine for SARS-CoV-2, the virus responsible for COVID-19, researchers are working to understand exactly how it causes the myriad of symptoms that seem to linger long after active viral infection.

31 Aug 2020

COVID-19 associated with serious blood clots in leg arteries

COVID-19 is associated with life-threatening blood clots in the arteries of the legs, according to a study published in Radiology.

16 Jul 2020

People suffering from rheumatoid arthritis with increased disease activity have high thrombosis risk

People suffering from rheumatoid arthritis with increased disease activity are more often affected by thrombosis.

5 Jun 2020

Study highlights need to focus on medications that address clot formation

Earlier this week, the BBC reported that one-third of COVID-19 patients developed dangerous blood clots.

19 May 2020

Adolescent obesity carries higher thrombus risk later in life

Men with a history of obesity in their late teens are, in adult life, more at risk of a blood clot (thrombus) in a leg or lung, according to a study from the University of Gothenburg study shows.

29 Apr 2020

Blood clots speed up aneurysm growth and increase rupture risk, warn researchers

A study reports an important discovery about abdominal aortic aneurysms that could help to identify high-risk patients who need to be monitored more closely.

28 Jan 2020

Researcher receives $7,637 funding for thrombus proteomic analysis

Virginia Espina, Research Associate Professor, Applied Proteomics and Molecular Medicine, received $7,637 from Mayo Clinic for: "Thrombus proteomic analysis."

8 Dec 2019

Researchers lay foundation for reliable blood clotting molecule models

Blood clots have long been implicated in heart attacks and strokes, together accounting for almost half of deaths annually in the United States.

19 Nov 2019

Miniscule robots like "Magic School Bus" could clear blood clots

Pulmonary embolism is a condition where a clot forms and blocks the arteries of the lungs and this restricts the blood flow to the lungs and lowers the amount of oxygen reaching the different organs. Statistics from the National Institutes of Health show that pulmonary embolism leads to nearly 200,000 to 300,000 deaths in the United States annually putting it at number three in cardiovascular diseases right after heart attack and stroke.

19 Nov 2019

New ESC guidelines for diagnosis and management of pulmonary embolism published

The European Society of Cardiology Guidelines on acute pulmonary embolism are published online today in European Heart Journal, and on the ESC website. They were developed in collaboration with the European Respiratory Society.

31 Aug 2019