Dramatic advances in the fields of biochemistry, cell and molecular biology, genetics, biomedical engineering and materials science have given rise to the remarkable new cross-disciplinary field of tissue engineering. Tissue engineering uses synthetic or naturally derived, engineered biomaterials to replace damaged or defective tissues, such as bone, skin, and even organs.
Cell-based therapies could offer a way to treat cartilage injuries before the ultimate damage of osteoarthritis on articular cartilage.
The third annual Cardiovascular Tissue Engineering Symposium met at the University of Alabama at Birmingham last month, a gathering of noted physicians and scientists who share the goal of creating new tissues and new knowledge that can prevent or repair heart disease and heart attacks.
Researchers have developed a new model to analyze tissue engineered cartilage that allows for the use of a single method to assess functional tissue mechanics in cartilage constructs at all stages of development from the laboratory through large animal testing.
The use of human hair-derived keratin biomaterials to regenerate skeletal muscle has shown promise in new research that documents significant increases in both new muscle tissue formation and muscle function among mouse models of volumetric muscle loss.
In a preclinical study in mice and human cells, researchers report that selectively removing old or 'senescent' cells from joints could stop and even reverse the progression of osteoarthritis.
Researchers are pursuing an innovative and unexpected new avenue in the quest to fight antibiotic resistance: synthetic mucus. By studying and replicating mucus' natural ability to control pathogenic bacteria, the scientists hope to find new methods for combating infections.
Using the gene-editing tool CRISPR/Cas9, researchers at University of California San Diego School of Medicine and Shiley Eye Institute at UC San Diego Health, with colleagues in China, have reprogrammed mutated rod photoreceptors to become functioning cone photoreceptors, reversing cellular degeneration and restoring visual function in two mouse models of retinitis pigmentosa.
According to research published online in The FASEB Journal, scientists have discovered a way to increase the amount of metabolism-boosting brown adipose tissue (BAT) ("good" fat) by employing two receptors on BAT cells as potential therapeutic targets.
Researchers from UPM and CSIC have employed waste from the agri-food industry to develop biomaterials that are able to act as matrices to regenerate bone and cartilage tissues, which is of great interest for the treatment of diseases related to aging.
Scientists have been working diligently to create engineered tissue implants to repair or replace damaged or diseased tissue and organs; but their success hinges on the ability to build a sturdy connection linking the implant's blood vessels and the patient's existing vasculature.
Researchers face a fundamental challenge as they seek to scale up human tissue regeneration from small lab samples to full-size tissues, bones, even whole organs to implant in people to treat disease or traumatic injuries: how to establish a vascular system that delivers blood deep into the developing tissue.
A Phase I clinical trial that targeted individuals with new onset paraplegia to evaluate the safety of transplanting their own potentially neuroprotective Schwann cells into a trauma-induced spinal cord lesion showed no evidence of adverse effects after 1 year.
Borrowing from nature is an age-old theme in science. Form and function go hand-in-hand in the natural world and the structures created by plants and animals are only rarely improved on by humans.
A team of researchers in Japan has developed a new platform for culturing human pluripotent stem cells that provides far more control of culture conditions than previous tools by using micro and nanotechnologies.
For millions of sufferers, there is nothing more debilitating than chronic back or joint pain. It can feel like a lifetime of misery.
A multidisciplinary team led by Gordana Vunjak-Novakovic, Mikati Foundation Professor of Biomedical Engineering and Medical Sciences at Columbia Engineering, and Matt Bacchetta, associate professor of surgery at Columbia University Medical Center and NewYork-Presbyterian has--for the first time--maintained a fully functional lung outside the body for several days.
Researchers working as part of the University of Georgia's Regenerative Bioscience Center have developed a new way to identify and sort stem cells that may one day allow clinicians to restore vision to people with damaged corneas using the patient's own eye tissue.
Researchers have demonstrated the potential to engineer brown adipose tissue, which has therapeutic promise to treat metabolic diseases such as obesity and type 2 diabetes, from white adipose-derived stem cells.
Harvard researchers have developed a lightweight, portable nanofiber fabrication device that could one day be used to dress wounds on a battlefield or dress shoppers in customizable fabrics.
Irish scientists are developing an advanced technology to speed up bone repair in adults who have suffered severe fractures and bone degeneration.