Dramatic advances in the fields of biochemistry, cell and molecular biology, genetics, biomedical engineering and materials science have given rise to the remarkable new cross-disciplinary field of tissue engineering. Tissue engineering uses synthetic or naturally derived, engineered biomaterials to replace damaged or defective tissues, such as bone, skin, and even organs.
Human mesenchymal stem cells (hMSCs) can develop into bone cells and are useful for tissue engineering and regeneration. However, when grown in the laboratory they quickly lose their ability to continue dividing and they die.
Today UBM Canon announces the expansion of its educational events aimed at the medical technology sector, with new 'Innovation' seminars being held this February, 2013. The seminars, named MedTech Innovate Seminars, will run concurrently with the MD&M West Conference and Exhibition, one of the largest medical design and manufacturing events in the world.
Dr Sanjay Kumar, MD, PhD has been named the winner of the Young Investigator Award by the journal STEM CELLS for leading research into the microenvironmental regulation of neural stem cells. The $10,000 prize is awarded annually to a young scientist whose paper has been judged to be of worldwide significance by a global jury.
The only way to protect against HIV and unintended pregnancy today is the condom. It's an effective technology, but not appropriate or popular in all situations.
Tufts University School of Engineering researchers have demonstrated silk-based implantable optics that offer significant improvement in tissue imaging while simultaneously enabling photo thermal therapy, administering drugs and monitoring drug delivery. The devices also lend themselves to a variety of other biomedical functions.
Liver disease is a very broad family of diseases. There are two main categories of liver disease:
A study published today in BioMed Central's open access journal Skeletal Muscle reports of a new therapeutic technique to repair and rebuild muscle for sufferers of degenerative muscle disorders. The therapy brings together two existing techniques for muscle repair - cell transplantation and tissue engineering - specifically, mesoangioblast stem cells delivered via a hydrogel cell-carrier matrix.
A study published this month by researchers at the University of Toronto and Toronto's Princess Margaret Hospital has shown that cells derived from the umbilical cord, "Human Umbilical Cord PeriVascular Cells" (HUCPVCs), are more effective in restoring heart function after an acute myocardial infarction (in common parlance, a heart attack) in a pre-clinical model than a similar cell population derived from bone marrow.
Gels that can be injected into the body, carrying drugs or cells that regenerate damaged tissue, hold promise for treating many types of disease, including cancer. However, these injectable gels don't always maintain their solid structure once inside the body.
Smart scaffolding that can guide cells, proteins and small-molecule drugs to make new tissue and repair damage inside the body is in the works at Rice University.
As they develop, vertebrate embryos form vertebrae in a sequential, time-controlled way. Scientists have determined previously that this process of body segmentation is controlled by a kind of "clock," regulated by the oscillating activity of certain genes within embryonic cells. But questions remain about how precisely this timing system works.
Spinal cord injury (SCI) can disrupt the body's sensitive signaling mechanisms that control blood pressure, breathing, and oxygen delivery to the heart and other organs during changes in body position. Cardiovascular (CV) disease is a leading cause of illness and death following SCI, and changes in baroreflex sensitivity-the body's ability to detect and respond to changes in blood pressure-may be predictive of a CV event.
A team of Duke Medicine researchers has engineered cartilage from induced pluripotent stem cells that were successfully grown and sorted for use in tissue repair and studies into cartilage injury and osteoarthritis.
Targeted T-cells can seek out and destroy tumor cells that carry specific antigen markers. Two novel anti-tumor therapies that take advantage of this T-cell response are described in articles published in Human Gene Therapy, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.
New, advanced techniques are needed that can mimic the normal blood supply that feeds natural bone to improve the viability and success of restorative procedures to replace damaged or diseased bone tissue using engineered constructs. A comprehensive review article describing the most promising strategies for vascularization of bone tissue substitutes is published in Tissue Engineering, Part B: Reviews, a peer-reviewed journal from Mary Ann Liebert, Inc.
SELEX is a rapid, efficient, and iterative high-throughput method for screening large libraries of molecules to identify those with the potential to be developed as drug compounds or research tools. Advances in SELEX technology that have enabled screening in live cells, called Cell-SELEX, are explored in a comprehensive Review article published in BioResearch Open Access, a bimonthly peer-reviewed open access journal from Mary Ann Liebert, Inc.
Researchers from the Department of Biomedical Engineering at Stony Brook University have developed a high-resolution, 3D optical Doppler imaging tomography technique that captures the effects of cocaine restricting the blood supply in vessels - including small capillaries - of the brain.
Modulating immune response to injury could accelerate the regeneration of severed peripheral nerves, a new study in an animal model has found. By altering activity of the macrophage cells that respond to injuries, researchers dramatically increased the rate at which nerve processes regrew.
The human body is proficient at making collagen. And human laboratories are getting better at it all the time. In a development that could lead to better drug design and new treatments for disease, Rice University researchers have made a major step toward synthesizing custom collagen. Rice scientists who have learned how to make collagen - the fibrous protein that binds cells together into organs and tissues - are now digging into its molecular structure to see how it forms and interacts with biological systems.
There are several reasons for this. One is because analysis involving different kinds of blood cells may require you to be able to separate red blood cells from white blood cells, or plasma from whole blood etc.
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