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Study explores the decline in viral load and immune response in COVID-19 patients

Researchers described the changes in viral ribonucleic acid the decline in viral load, and the immune response of SARS-CoV-2-infected patients, in a new preprint study.

22 Feb 2022

Response of peripheral immune cells to ex vivo SARS-CoV-2 exposure compared to SARS-CoV

Researchers characterized the responses of the PBMCs at the individual cell and cell type levels against SARS-CoV-2 and SARS-CoV ex vivo.

18 Feb 2022

Study shows expression of viral proteases may be used to quantitate SARS-CoV-2 infected cells

A new study describes a new method to quantify SARS-CoV-2 infection, which is much simpler and faster compared to existing methods.

14 Feb 2022

Rapid generation and evaluation of an mRNA vaccine candidate specific to Omicron

A recent study demonstrated the development of a potential SARS-CoV-2 Omicron variant-specific mRNA vaccine candidate.

10 Feb 2022

New personalized test to detect leukemia relapse sooner and avoid false negative results

Researchers have developed a new protocol for monitoring acute lymphoblastic leukemia (ALL), the most common cancer in children, to inform more effective treatment strategies and detect disease recurrence.

7 Feb 2022

Evolutionary history of ACE2 binding across a diverse range of sarbecoviruses and ACE2 orthologs

Researchers have been investigating sarbecovirus lineages and the ability of those lineages to evolve the ability to bind ACE2.

7 Feb 2022

Antigenic map of SARS-CoV-2 variants reveals amino acid substitutions that govern immune escape and immunodominance

Researchers use antigenic cartography to analyze cross-reactivity patterns of eight groups of human sera on a panel of SARS-CoV-2 variants.

2 Feb 2022

SARS-CoV-2 entry at the cell surface facilitated by trypsin

Exogenous trypsin treatment boosts SARS-CoV-2 infection in Vero E6 cells and promotes viral multiplication in cultured cells.

1 Feb 2022

Study shows monoclonal antibody and antiviral therapy are useful in preventing the severity of SARS-CoV-2 Omicron infection

In a new study, researchers assessed the efficacy of the FDA-approved therapeutic mAbs, as well as to small-molecule antiviral agents against the SARS-CoV-2 Omicron variant in Syrian hamsters.

21 Jan 2022

Exploring factors favoring transmission of SARS-CoV-2 Delta sublineage AY.4.2 over the Delta variant

In the present study, researchers isolated an infectious AY.4.2 strain of COVID-19 from the nasopharyngeal swab of a symptomatic individual from the Paris region. Then, they introduced the AY.4.2 signature mutations - T95I, Y145H, and A222V - in an expression plasmid coding the Delta protein to study the function of the AY.4.2 S protein.

13 Jan 2022

SARS-CoV-2 Omicron study on hamsters, shows virus results in a less severe disease

Researchers investigate the ability of immunity acquired from SARS-CoV-2 wild-type infection to protect against the Omicron variant in Syrian hamster models.

3 Jan 2022

Study highlights importance of positive and negative selection in evolution of SARS-CoV-2 variants

Researchers from the University of Colorado Anschutz Medical Campus have been investigating the changes imparted on the Gamma variant by three RBD mutations.

28 Dec 2021

Decline in protection against SARS-CoV-2 Omicron in prior infected and fully vaccinated

In a recent study posted to the medRxiv* preprint server, researchers investigated the distribution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta and Omicron variants among coronavirus disease 2019 (COVID-19) positive individuals who were either naive, fully vaccinated, or had a previous infection to further investigate possible escape from vaccine- or infection-induced immunity by Omicron compared to Delta.

22 Dec 2021

Efficacy of SARS-CoV2 variant-specific replicating RNA vaccines on SARS-CoV-2 variants of concern

A new study evaluates the repRNA vaccine expressing the SARS-CoV-2 spike protein for the B.1.1.7 and B.1.351 variants in mice and hamsters.

19 Dec 2021

Research suggests targeting fusion peptide-calcium interaction may help treat COVID-19

Researchers discovered that the entry of coronaviruses is a Ca2+-dependent process and focused their studies on the SARS-1 FP-Ca2+ interaction and its effect on membranes using electron spin resonance (ESR).

10 Dec 2021

Efficacy and safety of an RBD-based recombinant protein COVID-19 vaccine

A study developed a protein-based subunit vaccine, PHH-1V, that consisted of a recombinant RBD fusion heterodimer of the alpha) and beta variants of SARS-CoV-2.

26 Nov 2021

Antisense oligonucleotides engineered to inhibit SARS-CoV-2

In a paper recently uploaded to the bioRxiv* preprint server, structure-based ASOs are developed against SARS-CoV-2, intended to bond with RNA in its structured in situ form, rather than the more rarely encountered linear section, achieving greater affinity and specificity than linear ASOs, and demonstrating inhibition of virus replication in human cells.

30 Aug 2021