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Population-based COVID-19 prevalence surveys in Europe and Americas show risk of bias

A team of researchers from the Federal University of Health Sciences of Porto Alegre and the Federal University of Rio Grande do Sul performed a systematic review to assess these population-based COVID-19 prevalence surveys' reliability and biases qualitatively. Their study is published on the preprint server medRxiv.

26 Oct 2020

Researchers present COVID RdRp structure at 2.5A

In a recent bioRxiv* preprint publication, Christopher J. Russo et al. report the structure of favipiravir ribonucleoside triphosphate (favipiravir-RTP) in complex with the SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) bound to a template: primer RNA duplex. They determine the structure by electron cryomicroscopy (cryoEM) to a resolution of 2.5 Å.

26 Oct 2020

New inhibitor of SARS-CoV-2 RNA translation

As the search for effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibitors continues, a recent study by Yale University School of Medicine researchers published on the preprint server bioRxiv in October 2020 reports the inhibitory effect of the drug merofloxacin on frameshifting during SARS-CoV-2 replication.

26 Oct 2020

Biomimetic virus-like particles for safer positive controls in SARS-CoV-2 detection

In an attempt to overcome these issues, a team of researchers from various departments at the University of California San Diego recently proposed using biomimetic virus-like particles (VLPs) as positive controls for assays used in SARS-CoV-2 detection. Their study is published on the preprint server bioRxiv.

23 Oct 2020

Ancient elements in human DNA can activate powerful immune response to kill cancer cells

Ancient embedded elements in our DNA from generations past can activate a powerful immune response to kill cancer cells like an infection.

22 Oct 2020

Study shows ssRNA encapsidation results in stabilization of the Ebola virus nucleocapsid

The Ebola virus causes a serious infection with a mortality rate between 50% and 90%. Nucleoproteins in the virus assemble into a helical arrangement and encapsulate a single stranded RNA genome, ssRNA, to form a rodlike complex known as a nucleocapsid, which is critical to the function of the virus.

21 Oct 2020

Researchers use supercomputers to simulate the inner working of Ebola virus

As the world grapples with the coronavirus (COVID-19) pandemic, another virus has been raging again in the Democratic Republic of the Congo in recent months: Ebola.

21 Oct 2020

Androgen deprivation strategies could help mitigate SARS-CoV-2 infection

Since the beginning of the COVID-19 pandemic, researchers have noted that women are generally less severely affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This has led to the exploration into estrogen and androgens' role in the hyperinflammatory clinical phenotypes of COVID-19. A recent study published on the preprint server bioRxiv shows that drugs targeting androgens and TMPRSS2 inhibitors may potentially combat the pandemic.

20 Oct 2020

Cleveland Clinic joins new Center for Integrated Multi-Modal and Multi-Scale Nucleome Research

Cleveland Clinic has been named a participating institution for the newly established Center for Integrated Multi-Modal and Multi-Scale Nucleome Research, made possible by a recently awarded five-year, $6.5 million consortium grant from the National Institutes of Health Common Fund.

19 Oct 2020

Tracing lineage to demonstrate direct astrocyte-to-neuron conversion in mouse brain

Regeneration of functional new neurons to repair injured human brain is a long-term unsolved problem up till today.

16 Oct 2020

GIV protein involved in the immune system could form basis for novel therapeutics

The immune response to infections is a delicate balance. We need just enough action to clear away the offending bacteria or viruses, but not so much that our own bodies suffer collateral damage.

15 Oct 2020

Ct values can be used to estimate epidemic dynamics

Researchers recently showed that the varying population distribution of Cycle threshold (Ct) values from positive SARS-CoV-2 samples could help infer epidemic dynamics.

14 Oct 2020

FAU researchers receive NIH funding to analyze stem cell activation

Researchers from Florida Atlantic University's Schmidt College of Medicine hope to conquer a major limitation in the ability for scientists to engineer tissues for regenerative therapies for age-related and degenerative diseases.

14 Oct 2020

Alternate primers for whole-genome SARS-CoV-2 sequencing

A new study published on the preprint server bioRxiv* in October 2020 describes the gap frequencies and positions in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome and a set of alternative primers with a sequencing scheme to provide better genomic coverage and quality.

14 Oct 2020

Scientists discover new method to retrieve lost single-cell RNA-sequencing information

Sequencing RNA from individual cells can reveal a great deal of information about what those cells are doing in the body. MIT researchers have now greatly boosted the amount of information gleaned from each of those cells, by modifying the commonly used Seq-Well technique.

14 Oct 2020

Understanding the production of memory B cells and immune responses

The current COVID-19 climate has made vaccines, antibodies, and immune responses topics of everyday conversation.

12 Oct 2020

Study elucidates the role of ERβ in growth of skeletal muscle in female mice

Researchers at Kumamoto University, Japan generated mice lacking the estrogen receptor beta (ERβ) gene, both fiber-specific and muscle stem cell-specific, which resulted in abnormalities in the growth and regeneration of skeletal muscle in female mice.

12 Oct 2020

Scientists recreate initial steps of HIV infection in a test tube

Accomplishing a feat that had been a pipe dream for decades, scientists have recreated in a test tube the first steps of infection by HIV (human immunodeficiency virus), the virus that causes AIDS (acquired immunodeficiency syndrome).

9 Oct 2020

Mass production of SARS-CoV-2 ORF8 protein using a chemical-inducible system in tobacco BY-2 cells

Researchers from the Japan Advanced Institute of Science and Technology (JAIST) and Ishikawa Prefectural University, Japan, recently attempted to synthesize the ORF8 protein with the help of a chemical-inducible protein production system using tobacco BY-2 cells. This study has been published demonstrated in the preprint server, bioRxiv.

9 Oct 2020

Proteolytic cleavage of nucleocapsid helps SARS-CoV-2 evade host immune responses

A team of scientists of the University of Oxford reveals that the nucleocapsid protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) undergoes autoproteolysis, and that resulting products can escape the host immune responses and facilitate viral proliferation. The study is currently available on the bioRxiv preprint server.

7 Oct 2020

Transcription News and Research

Population-based COVID-19 prevalence surveys in Europe and Americas show risk of bias

Researchers present COVID RdRp structure at 2.5A

New inhibitor of SARS-CoV-2 RNA translation

Biomimetic virus-like particles for safer positive controls in SARS-CoV-2 detection

Ancient elements in human DNA can activate powerful immune response to kill cancer cells

Study shows ssRNA encapsidation results in stabilization of the Ebola virus nucleocapsid

Researchers use supercomputers to simulate the inner working of Ebola virus

Androgen deprivation strategies could help mitigate SARS-CoV-2 infection

Cleveland Clinic joins new Center for Integrated Multi-Modal and Multi-Scale Nucleome Research

Tracing lineage to demonstrate direct astrocyte-to-neuron conversion in mouse brain

GIV protein involved in the immune system could form basis for novel therapeutics

Ct values can be used to estimate epidemic dynamics

FAU researchers receive NIH funding to analyze stem cell activation

Alternate primers for whole-genome SARS-CoV-2 sequencing

Scientists discover new method to retrieve lost single-cell RNA-sequencing information

Understanding the production of memory B cells and immune responses

Study elucidates the role of ERβ in growth of skeletal muscle in female mice

Scientists recreate initial steps of HIV infection in a test tube

Mass production of SARS-CoV-2 ORF8 protein using a chemical-inducible system in tobacco BY-2 cells

Proteolytic cleavage of nucleocapsid helps SARS-CoV-2 evade host immune responses

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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