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Core promoter mutants of Hepatitis B Virus e Antigen associated with development of fulminant hepatitis and liver cancer

Scientists in Brown Medical School, Providence, USA, have found that core promoter mutants of Hepatitis B Virus e Antigen replicate at up to 10-fold higher levels in transfected human hepatoma cells than the wild-type virus.

9 Jan 2005

Discovery of gene related to p53 called Bnip3L that can also cause cell death

Researchers have known for a decade that the p53 tumor suppressor gene is important for killing cells as they proliferate under low-oxygen conditions inside tumors.

5 Jan 2005

Ubiquitination protects against improper Notch signaling

The Notch pathway is an important molecular signaling mechanism whose existence has been known, or at least hinted at, for nearly a century since the identification of a mutant strain of Drosophila fruit flies with "notched" wings in Thomas Hunt Morgan's lab in 1910.

28 Dec 2004

Significant advance in understanding the human genome

An Oregon Health & Science University-led development of a technique for identifying control elements that drive the expression of genes in brain cells could unleash the disease-fighting potential of the much-hailed human genome.

28 Dec 2004

Rett Syndrome, the first identified epigenetic disease - linked to specific defects in the three-dimensional folding of chromatin

Sometime between the age of 6 and 18 months, after a period of seemingly normal development, girls affected with Rett Syndrome lose interest in play; they gradually become withdrawn and anxious, develop autistic-like behaviors, and acquire specific symptoms like repetitive teeth-grinding and hand-wringing.

20 Dec 2004

Genetic mutations and cellular modifications may provide clues to the associations between slight genetic abnormalities and often fatal diseases

Modern research is delving deep into the human genome to find the answers to medical mysteries and, hopefully, cures for the most deadly diseases. According to four new studies presented during the 46th Annual Meeting of the American Society of Hematology

5 Dec 2004

Cancer Research Technology grants AstraZeneca an exclusive license to a key patent

Cancer Research Technology Limited has announced that AstraZeneca has licensed exclusive worldwide rights to a patent family relating to a nuclear receptor/co-activator binding motif.

1 Dec 2004

New research may lead to treatments for atherosclerosis

Scientists are one step closer to deciphering the molecular signaling process controlling innate immunity with the discovery that a molecule called IRAK1 regulates the expression of the anti-inflammatory cytokine IL-10. Because atherosclerosis patients often have elevated IL-10 levels, IRAK1 may be a viable target for developing therapeutics for atherosclerosis.

29 Nov 2004

Study links a novel protein pathway to the aggressive progression of breast cancer

Cytogen Corporation today announced the publication of a study linking a novel protein pathway to the aggressive progression of breast cancer.

24 Nov 2004

Discovery of gene mutation in fruit flies that alters sensitivity to crack cocaine

Researchers at the University of California, San Francisco (UCSF) and New York University have discovered a gene mutation in fruit flies that alters sensitivity to crack cocaine and also regulates their internal body clock.

23 Nov 2004

Study provides the first detailed description of errors by hospital staff nurses

A University of Pennsylvania School of Nursing study provides the first detailed description of the nature and prevalence of errors by hospital staff nurses.

20 Nov 2004

Parainfluenza virus found in Hong Kong patients

A CHP spokesman said PIVs are spread by respiratory secretions through close contact with infected persons or contact with contaminated surfaces or objects.

18 Nov 2004

Researchers attempt to quantify processes underlying cell heterogeneity

Combining the latest methods in gene splicing and computer modeling, Rice University researchers are trying to develop a predictive framework for one of the most basic and complex biological phenomena — cellular heterogeneity, or the ability of genetic clones to act and behave differently when exposed to the same set of environmental stimuli.

8 Nov 2004

STAT3 protein could lead to new ways to prevent skin cancer

Scientists at The University of Texas M. D. Anderson Cancer Center have identified a protein that serves as a master regulator of skin cancer - a finding that could lead to new ways to prevent skin cancer before it starts.

4 Nov 2004

New role for a key protein involved in muscle contraction

Overturning a scientific stereotype, researchers at the University of Illinois at Chicago have discovered a new role for a key protein involved in muscle contraction and shown it is present not just in the cytoplasm of cells but in the nucleus as well.

1 Nov 2004

Red wine delivered though an aerosol for COPD, asthma, and possibly even arthritis

Homing in on mechanisms for the reported effectiveness of resveratrol, which is found in red wine, researchers at Imperial College London, England, confirmed its broad anti-inflammatory action, and found potential for applications in chronic obstructive pulmonary disease (COPD), asthma, and possibly even arthritis.

29 Oct 2004

Transcription News and Research

Core promoter mutants of Hepatitis B Virus e Antigen associated with development of fulminant hepatitis and liver cancer

Discovery of gene related to p53 called Bnip3L that can also cause cell death

Ubiquitination protects against improper Notch signaling

Significant advance in understanding the human genome

Rett Syndrome, the first identified epigenetic disease - linked to specific defects in the three-dimensional folding of chromatin

Genetic mutations and cellular modifications may provide clues to the associations between slight genetic abnormalities and often fatal diseases

Cancer Research Technology grants AstraZeneca an exclusive license to a key patent

New research may lead to treatments for atherosclerosis

Study links a novel protein pathway to the aggressive progression of breast cancer

Discovery of gene mutation in fruit flies that alters sensitivity to crack cocaine

Study provides the first detailed description of errors by hospital staff nurses

Parainfluenza virus found in Hong Kong patients

Researchers attempt to quantify processes underlying cell heterogeneity

STAT3 protein could lead to new ways to prevent skin cancer

New role for a key protein involved in muscle contraction

Red wine delivered though an aerosol for COPD, asthma, and possibly even arthritis

Micro-array technology is revolutionising current drug development

Researchers are one step closer to understanding how high carbohydrate diets lead to obesity and diabetes

Researchers stimulate the body to repair tissue damaged by peripheral arterial obstructive disease

Researchers suggest how to generate B cells from stem cells

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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