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New compounds show potential to mimic benefits of exercise

Doctors have long prescribed exercise to improve and protect health. In the future, a pill may offer some of the same benefits as exercise.

18 Mar 2024

Measles outbreak in Illinois underscores critical need for vaccination

Study reports a measles outbreak among five unvaccinated children in Illinois, highlighting the disease's high transmissibility even among those not in direct contact, underscoring the critical importance of vaccination.

17 Mar 2024

Researchers identify T-cell subsets as effective therapeutic target for preventing transplant rejection

Houston Methodist researchers identified a troublesome subset of T-cells in transplant recipients that may be a more effective therapeutic target for preventing transplant rejection in patients.

14 Mar 2024

Innovative super minigene to revolutionize spinal muscular atrophy research

Ravindra Singh has spent years studying a gene that when missing or mutated causes spinal muscular atrophy (SMA), a deadly disease that's among the most common genetic disorders in children.

13 Mar 2024

Study reveals TDP-43 protein's key role in blood vessel formation and integrity

Defects in the blood vessel network of the central nervous system have been linked to early symptoms of neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

13 Mar 2024

Understanding how chikungunya virus affects the brain and body

The chikungunya virus, transmitted by Aedes aegypti and Aedes albopictus mosquitoes and responsible for more than 900 deaths in Brazil since it arrived around ten years ago, is capable of spreading through the blood, reaching multiple organs and crossing the blood-brain barrier, which protects the central nervous system.

12 Mar 2024

Protein Kdm1a plays a crucial role in preserving neuronal identity, study shows

Epigenetic processes allow different cell types to emerge from a single genome. Throughout development, cells differentiate and acquire distinct characteristics by expressing the same genome in different ways.

12 Mar 2024

Groundbreaking study unveils sex-specific genetic influences on blood pressure

Genetic heterogeneity of blood pressure (BP) effects between sexes.

12 Mar 2024

Researchers forge new path to combat viruses and cancers with helicase inhibitors

Helicases are enzymes that unwind DNA and RNA. They're central to cellular life, implicated in a number of cancers and infections-;and, alas, extraordinarily difficult to target with drugs.

9 Mar 2024

Study unravels FOXO1's influence on blood vessel development

The human vascular system, a complex network of blood vessels, plays an essential role in maintaining health. Understanding the molecular mechanisms underlying vascular development is important for tackling age-related disorders.

9 Mar 2024

The effects of high maternal folate intake on the health outcomes of offspring

Researchers summarized what is known about the effects of excessive folic acid (FA) supplementation for mothers on children.

8 Mar 2024

New method simplifies production of limb progenitor cells from fibroblasts

In a collaborative study, researchers from Kyushu University and Harvard Medical School have identified proteins that can turn or "reprogram" fibroblasts -; the most commonly found cells in skin and connective tissue -; into cells with similar properties to limb progenitor cells.

4 Mar 2024

Unlocking the secrets of T follicular helper cells for better treatment strategies

T follicular helper cells (Tfh) are essential for strong antibody-mediated reactions of our immune system during infections and vaccinations. However, if they get out of control, this can cause diseases such as autoimmunity, allergies or cancer.

1 Mar 2024

Breakthrough gene silencing method slashes cholesterol for a year in mice, no DNA damage

Researchers developed an engineered transcriptional repressor that durably silences the Pcsk9 gene in mice, reducing cholesterol levels for up to a year with a single treatment, showcasing a potential breakthrough in genetic disorder treatments without the risks of DNA mutation.

29 Feb 2024

Association of estrogen-containing menopause hormonal therapy with COVID-19 mortality

Researchers evaluated coronavirus disease 2019 (COVID-19)-related mortality among perimenopausal women.

29 Feb 2024

UCLA researchers uncover dual role of GAN gene in neurological disorder, head and neck cancer

Researchers from the UCLA Health Jonsson Comprehensive Cancer Center show for the first time that a gene usually linked to giant axonal neuropathy, a rare and severe neurological condition, also plays a role in inhibiting aggressive tumor cell growth in head and neck cancers.

29 Feb 2024