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New sequencing tool speeds up SARS-CoV-2 outbreak response and informs treatment

Announcing a new article publication for Zoonoses journal. In the context of two Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) outbreaks involving local transmission and an international flight, the authors of this article used meta-transcriptome and multi-amplicon sequencing to successfully acquire the complete viral genome sequences from clinical samples with varying viral loads.

1 Feb 2024

Is there an association between vitamin D, immunocompetence, and aging?

The role of an individual’s immunocompetence in the responsiveness to vitamin D.

1 Feb 2024

Immunocompromised patients show prolonged SARS-CoV-2 infection and unique mutations

study identifies risk factors for prolonged SARS-CoV-2 infection in immunocompromised patients, revealing that B-cell dysfunction, solid organ transplantation, and AIDS lead to longer infections and unique spike mutations.

31 Jan 2024

Ancient genomes unearth degenerate transposable elements in human DNA

The human genome, an intricate tapestry of genetic information for life, has proven to be a treasure trove of strange features. Among them are segments of DNA that can "jump around" and move within the genome, known as "transposable elements" (TEs).

30 Jan 2024

Weill Cornell Medicine researcher wins $2.1 million grant to study repetitive DNA and RNA sequences

Dr. Jeannine Gerhardt, an assistant professor of stem cell biology in obstetrics and gynecology and in reproductive medicine at Weill Cornell Medicine, has received a five-year, $2.1 million grant from the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health, for the study of repetitive DNA and RNA sequences and the mechanisms by which they cause cell dysfunction and diseases.

30 Jan 2024

Prime editing takes gene therapy to the next level

This study is led by Prof. Xianqun Fan (Department of Ophthalmology, Shanghai Jiao Tong University School of Medicine Affiliated Ninth People's Hospital).

27 Jan 2024

The association between handgrip strength and functional outcomes in long COVID-19

The association between dynapenia with long coronavirus disease 2019 (COVID-19).

26 Jan 2024

Balancing efficacy and safety: The challenges of mRNA drugs and vaccines in modern medicine

Researchers analyzed the toxicity concerns and advancements in mRNA therapeutics, focusing on their cellular toxicity, reactogenicity, and distribution, and discussed the challenges and benefits of mRNA research.

24 Jan 2024

Groundbreaking technology shows immense potential for treating ischemic retinopathy

A groundbreaking technology with immense potential in treating ischemic retinopathy in premature infants and diabetic patients has been developed by Professor Byoung Heon Kang and his research team in the Department of Biological Sciences at UNIST, in collaboration with Professor Dong Ho Park's team at Kyungpook National University Hospital. Ischemic retinopathy, characterized by the breakdown of the blood-retinal barrier and abnormal blood vessel growth, often leads to vision impairment and loss.

24 Jan 2024

Rutgers researchers devise strategy to boost prostate cancer treatment efficacy

Rutgers researchers can predict which patients will benefit from a popular prostate cancer drug – and have devised a strategy that may make the treatment work longer.

22 Jan 2024

Discovery of toxic and protective short RNAs associated with Alzheimer's disease and superior memory capacity

Researchers explored how Death Induced by Survival gene Elimination through the analysis of RNA-induced silencing complex-bound short RNAs in Alzheimer's disease models influences neuronal survival and correlates with neurotoxicity in AD.

22 Jan 2024

Innovative COVID-19 test prototype uses bioluminescence for speedier results

Researchers used a luciferase-independent luminescence test to investigate whether the wild-type SARS-CoV-2 spike protein possesses pseudo-luciferase activity for Cypridina luciferin.

22 Jan 2024

Study shows Omicron variants evade immune system like predecessors, suggesting key evolutionary trait in SARS-CoV-2

Researchers compared SARS-CoV-2 Omicron variant of concern replication in human cell lines and primary airway cultures and measured host responses to infection.

19 Jan 2024

Study reveals intestinal helminth infection diminishes T cell response to COVID-19 mRNA vaccine

Study investigates the impact of helminth infection on COVID-19 mRNA vaccine efficacy, revealing that while antibody responses remain largely unaffected, T-cell responses are significantly impaired, particularly against Omicron variants.

17 Jan 2024

Anti-HIV drugs can be used to prevent inflammatory complications of bacterial sepsis

Bacterial infections can lead to the formation of abscesses -; pockets of dead cells and debris surrounded by inflammatory immune cells. Bacteria multiply within abscesses, causing more inflammation and further damage to surrounding tissues.

17 Jan 2024

Unlocking the anti-inflammatory secrets of bergamot byproducts

The positive effect of bergamot derivatives.

17 Jan 2024

GRK2: A new target for inhibiting macrophage infiltration and angiogenesis in rheumatoid arthritis

This new article publication from Acta Pharmaceutica Sinica B, discusses how GRK2 inhibits Flt-1+ macrophage infiltration and its proangiogenic properties in rheumatoid arthritis.

15 Jan 2024

RBM5 identified as key regulator of HOXA9 in acute myeloid leukemia

The protein HOXA9 is overexpressed in most acute myeloid leukemia (AML) cases and is associated with poor patient outcomes.

12 Jan 2024

Long-term expansion and self-organization of human fetal brain organoids

Researchers establish fetal brain organoids as a versatile platform for brain cancer modeling.

12 Jan 2024

New peptide library paves the way for targeting elusive cancer factor MYC

Researchers developed a second-generation NTB bicyclic peptide library, identifying NT-B2R, a peptide that effectively targets MYC, a key factor in most human cancers, demonstrating its potential in inhibiting MYC transcription activities and cancer cell proliferation.

8 Jan 2024

Transcription News and Research

New sequencing tool speeds up SARS-CoV-2 outbreak response and informs treatment

Is there an association between vitamin D, immunocompetence, and aging?

Immunocompromised patients show prolonged SARS-CoV-2 infection and unique mutations

Ancient genomes unearth degenerate transposable elements in human DNA

Weill Cornell Medicine researcher wins $2.1 million grant to study repetitive DNA and RNA sequences

Prime editing takes gene therapy to the next level

The association between handgrip strength and functional outcomes in long COVID-19

Balancing efficacy and safety: The challenges of mRNA drugs and vaccines in modern medicine

Groundbreaking technology shows immense potential for treating ischemic retinopathy

Rutgers researchers devise strategy to boost prostate cancer treatment efficacy

Discovery of toxic and protective short RNAs associated with Alzheimer's disease and superior memory capacity

Innovative COVID-19 test prototype uses bioluminescence for speedier results

Study shows Omicron variants evade immune system like predecessors, suggesting key evolutionary trait in SARS-CoV-2

Study reveals intestinal helminth infection diminishes T cell response to COVID-19 mRNA vaccine

Anti-HIV drugs can be used to prevent inflammatory complications of bacterial sepsis

Unlocking the anti-inflammatory secrets of bergamot byproducts

GRK2: A new target for inhibiting macrophage infiltration and angiogenesis in rheumatoid arthritis

RBM5 identified as key regulator of HOXA9 in acute myeloid leukemia

Long-term expansion and self-organization of human fetal brain organoids

New peptide library paves the way for targeting elusive cancer factor MYC

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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