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Research identifies Th1 memory CD4+ T cells as key to protect against emerging poxvirus skin infections

Researchers demonstrate that T helper 1 effector memory cluster of differentiation 4 T cells provide immunity against poxviruses

27 Apr 2023

A rapid and affordable in vitro model to test SARS-CoV-2 susceptibility in animal species

Research investigates the susceptibility of seven bat species to SARS-CoV-2 by expressing their ACE2 receptor in a non-permissive avian cell line. The study found that all seven bat species were susceptible to SARS-CoV-2, but the level of virus replication differed between bat species and virus variants.

24 Apr 2023

Biological underpinnings of a reproductive disorder caused by mutation of autism gene

A University of California, Riverside, study has identified the biological underpinnings of a reproductive disorder caused by the mutation of a gene.

5 Apr 2023

Live attenuated nasal vaccine elicits superior immunity to SARS-CoV-2 variants in hamsters

Since the beginning of the COVID-19 pandemic, researchers have been working on mucosal vaccines that can be administered through the nose.

4 Apr 2023

Endothelial deletion of the Wt1 gene affects coronary vessel formation and myocardial development

How is the mammals' heart formed? What role do endothelial cells play? Do the same pathways and genes involved in the formation of the embryonic heart also play a role in repair processes?

4 Apr 2023

Study identifies ultra-broad SARS-CoV-2 neutralizing antibodies that target various spike epitopes

Researchers screened the circulating B lymphocyte repertoires of coronavirus disease 2019 convalescents and vaccines using multiplexed antigen panels.

3 Apr 2023

Scientists uncover novel role of human-CIDEC gene in improving metabolic dysfunction and cardiovascular health

A team of researchers from Ohio University's Heritage College of Osteopathic Medicine recently discovered a novel role of human-CIDEC gene in improving metabolic dysfunction and cardiovascular health.

29 Mar 2023

VR imaging system illuminates functional brain network dynamics in autism model

An international research collaboration has developed a VR imaging system that can measure a wide range of neural activity in the cortices of mice during active behavior.

28 Mar 2023

Which exercises might reduce pro-inflammatory and enhance anti-inflammatory cytokines in older people with mild cognitive impairment or Alzheimer's disease?

Researchers investigated which exercises might enhance anti-inflammatory cytokines and reduce pro-inflammatory cytokines in patients with dementia or mild cognitive impairment.

17 Mar 2023

Scientists develop genetically defined mouse models for multiple myeloma subtypes

A team of scientists led by Martin Janz and Klaus Rajewsky at the Max Delbrück Center has successfully generated genetically defined mouse models for two subtypes of multiple myeloma.

16 Mar 2023

Bispecific antibody shows improved efficacy against SARS-CoV-2 variants

Researchers from The University of Texas MD Anderson Cancer Center have developed fully human bispecific antibodies, as revealed in a recent study. These antibodies can bind to two distinct epitopes of the receptor binding domain (RBD) of the SARS-CoV-2 spike protein and have demonstrated the ability to neutralize various strains of the virus, including the Omicron variant.

14 Mar 2023

Researchers optically evoke tachycardia enhanced anxiety-like behaviour

In a recent study published in the journal Nature, researchers devised a non-invasive optogenetic and wearable cardiac pacemaker for accurate and specific control of cardiac rhythm for ≤900 beats per minute (bpm), enabled by micro-light-emitting display (LED) harness and systemic channelrhodopsin delivery.

6 Mar 2023

Researchers report the circulation of a novel MERS-like coronavirus in Malayan pangolins

Researchers reported the circulation of a novel MERS-like coronavirus among Malayan pangolins, Manis javanica HKU4-associated CoV (MjHKU4r-CoV).

21 Feb 2023

Genome editing prevents hypertrophic cardiomyopathy in mice

In a recent study published in the journal PLoS Digital Health, researchers pursued one-time cures for hypertrophic cardiomyopathy (HCM). They used a previously constructed murine model of HCM, designated as R403Q-129SvEv, to evaluate two different genetic therapies, as follows:

19 Feb 2023

Exploring the potential of betalain-engineered vegetables in conferring anti-inflammatory properties

Metabolic engineering is a field of plant biotechnology that seeks to genetically modify plant metabolic pathways to generate plant varieties with improved health benefits.

17 Feb 2023

The immunogenicity of two leading malaria vaccine candidates delivered as mRNA-LNP vaccines

Researchers evaluated the immunogenicity of two vaccine candidates, Pfs25 and PfCSP, based on the mRNA-lipid nanoparticle (LNP) platform.

13 Feb 2023

Study suggests SARS-CoV-2 is likely to only infect placental mammals

Researchers perform ontological and taxonomical analysis of human coronavirus hosts.

9 Feb 2023

The effectiveness of intranasal COVID-19 vaccination in healthy adults

A recent study discusses the safety profiles and immunogenicity of the nasal BBV154 COVID-19 vaccine in healthy adults.

3 Feb 2023

Researchers devise a novel potential IBD treatment strategy that eliminates pathogenic T cells and encourages the proliferation of regulatory T cells

Researchers investigated the CAMCI strategy as an immunotherapeutic option for inflammatory bowel disease.

31 Jan 2023

Serotonin can potentially accelerate degenerative mitral regurgitation, study says

Serotonin can impact the mitral valve of the heart and potentially accelerate a cardiac condition known as degenerative mitral regurgitation, according to a new study led by researchers at Columbia University's Department of Surgery in collaboration with the Pediatric Heart Valve Center at Children's Hospital of Philadelphia, the University of Pennsylvania, and the Valley Hospital Heart Institute.

29 Jan 2023