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Study uncovers initial folding mechanism of membrane proteins, key in design of new drugs

An international team coordinated by the Interdisciplinary Research Structure in Biotechnology and Biomedicine of the University of Valencia has proved how the folding of membrane proteins begins before they are inserted into biological membranes, a fact that has been central to the biochemical research for decades.

19 Dec 2018

$Type 2 diabetes drug may be used to treat heart failure with preserved ejection fraction$

Type 2 diabetes drug may be used to treat heart failure with preserved ejection fraction

Researchers at the University of Arizona have discovered that metformin, a drug commonly used to treat type 2 diabetes, might also be used to treat heart failure with preserved ejection fraction, a condition that is predicted to affect over 8% of people ages 65 or older by the year 2020.

19 Dec 2018

Active ingredient in eye drops shows promise for treating aggressive blood cancer

An active ingredient in eye drops that were being developed for the treatment of a form of eye disease has shown promise for treating an aggressive form of blood cancer. Scientists at the Wellcome Sanger Institute, University of Cambridge, University of Nottingham and their collaborators have found that this compound, which targets an essential cancer gene, could kill leukemia cells without harming non-leukemic blood cells.

19 Dec 2018

Researchers identify potential target for new breast cancer treatments

Researchers from the School of Basic & Medical Biosciences have identified a potential target that could lead to new treatments for triple negative breast cancer.

18 Dec 2018

National Biofilms Innovation Centre award grant to Neem Biotech for novel anti-biofilm drug development

Neem Biotech, Welsh Wound Innovation Centre and Sheffield Collaboratorium for Antimicrobial Resistance and Biofilms Awarded NBIC Grant to Advance Development of Neem’s First-in-Class Treatments for Wound Infections.

From Neem Biotech 17 Dec 2018

RNA sequencing offers novel insights into the microbiome

Researchers have come up with a revolutionary strategy for studying the activity of the gut microbiome – using high-throughput sequencing of tRNA.

17 Dec 2018

Research focuses on optimization of solid lipid nanoparticle that encapsulates Vinorelbine bitartrate

Vinorelbine Bitartrate, a semi-synthetic vinca alkaloid was approved by the FDA for breast cancer treatment, as it has been proven to be beneficial for first line of defense and subsequent therapies. But its hydrophilic and thermolabile structure causes hindrance to oral clinical translation.

17 Dec 2018

Researchers uncover microRNAs involved in the control of social behavior

The recent discovery of microRNAs as key regulators of biological processes has fueled an explosion of research activity into their function in health and disease.

14 Dec 2018

Scientists discover rules that determine precision of CRISPR/Cas9 genome editing in human cells

Scientists at the Francis Crick Institute have discovered a set of simple rules that determine the precision of CRISPR/Cas9 genome editing in human cells.

14 Dec 2018

Research identifies nerve-signaling pathway behind sustained pain after injury

A toddler puts her hand on a hot stove and swiftly withdraws it. Alas, it's too late--the child's finger has sustained a minor burn. To soothe the pain, she puts the burned finger in her mouth.

13 Dec 2018

Talking about memories enhances the wellbeing of older and younger people

This December, more than one million elderly people will experience loneliness and isolation according to figures by Age UK.

6 Dec 2018

NIH-funded tissue chips that model aspects of the human immune system sent to space

When traveling in space, astronauts experience physiological changes normally associated with aging, such as bone loss, muscle deterioration and altered immune systems. When the astronauts return to Earth, the changes often reverse.

5 Dec 2018

New approach turns B cells into factories that secrete sacs containing microRNAs

Cancer immunotherapy -- efforts to better arm a patient's own immune system to attack tumors -- has shown great potential for treating some cancers. Yet immunotherapy doesn't work for everyone, and some types of treatment can cause serious side effects.

5 Dec 2018

Researcher discovers key differences in protein production between healthy cells and tumors

The human body is made up of more than 200 types of cell, from bone and brain to liver and lung. Each cell type is determined by the particular combination of proteins it produces.

4 Dec 2018

UA researchers discover promising lead in genetic approach to treating deadly brain cancer

Glioblastoma, a deadly brain cancer that has grabbed headlines for claiming the lives of Sens. Edward Kennedy and John McCain, could be "tricked" into sparing more of its victims.

30 Nov 2018

New project launched to map out lung cancer immunology

A 'rule book' to guide precision combination immunotherapies and to speed up the development of new lung cancer treatments will be created as part of a collaboration between Cancer Research UK, the Francis Crick Institute and Bristol-Myers Squibb, announced today (Friday).

29 Nov 2018

Antibiotic could protect against age-related brain diseases

An antibiotic, minocycline, can increase the lifespan of roundworms by preventing the build-up of proteins during aging, a study in the open-access journal eLife reports.

28 Nov 2018

Pitt research team explores whether 'active wrinkles' may help improve synthetic graft design

During a coronary bypass procedure, surgeons redirect blood flow using an autologous bypass graft, most often derived from the patient's own veins. However, in certain situations where the patient does not have a suitable vein, surgeons must rely on synthetic vascular grafts which, while life-saving, are more prone to clot formation that eventually obstructs the graft.

28 Nov 2018

Scientists discover important hallmark of aging in neuronal cells

MIT researchers have discovered that free radicals cause a build-up of short RNA snippets which could contribute to neuronal ageing and cognitive decline.

27 Nov 2018

Research may pave way for development of potent weapons against cancer

Despite significant advances in cancer research, the disease continues to exact a devastating toll. Because cancer is a disease of the body's own cells, which mutate and develop under evolutionary pressure, conventional treatments like chemotherapy and radiation often leave behind a residue of resistant cells that go on to expand and wreak havoc.

27 Nov 2018

Translation News and Research

Study uncovers initial folding mechanism of membrane proteins, key in design of new drugs

Type 2 diabetes drug may be used to treat heart failure with preserved ejection fraction

Active ingredient in eye drops shows promise for treating aggressive blood cancer

Researchers identify potential target for new breast cancer treatments

National Biofilms Innovation Centre award grant to Neem Biotech for novel anti-biofilm drug development

RNA sequencing offers novel insights into the microbiome

Research focuses on optimization of solid lipid nanoparticle that encapsulates Vinorelbine bitartrate

Researchers uncover microRNAs involved in the control of social behavior

Scientists discover rules that determine precision of CRISPR/Cas9 genome editing in human cells

Research identifies nerve-signaling pathway behind sustained pain after injury

Talking about memories enhances the wellbeing of older and younger people

NIH-funded tissue chips that model aspects of the human immune system sent to space

New approach turns B cells into factories that secrete sacs containing microRNAs

Researcher discovers key differences in protein production between healthy cells and tumors

UA researchers discover promising lead in genetic approach to treating deadly brain cancer

New project launched to map out lung cancer immunology

Antibiotic could protect against age-related brain diseases

Pitt research team explores whether 'active wrinkles' may help improve synthetic graft design

Scientists discover important hallmark of aging in neuronal cells

Research may pave way for development of potent weapons against cancer

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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