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Research findings offer path for drug discovery to treat hyperaldosteronism

A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute, in collaboration with researchers at Eunice Kennedy Shriver National Institute of Child Health and Human Development, part of the National Institutes of Health, identifies a mechanism that explains the development of hyperaldosteronism.

7 Dec 2017

Overcoming Challenges of Assays of Complex Cellular Models with Real-Time Live-Cell Analysis

There's a continued drive towards making in vitro assays ever more translational towards in vivo models and ultimately the clinic. This ties in with the resurgence of phenotypic screening and is a response to the perceived poor translation of the traditional simple cell-based assays, often developed to study just single protein targets.

From Sartorius 5 Dec 2017

OICR announces innovative initiative to drive development of new cancer therapies

The Ontario Institute for Cancer Research today announced the Cancer Therapeutics Innovation Pipeline initiative and the first 10 projects selected in CTIP's inaugural round of funding.

4 Dec 2017

UC San Diego researchers receive nearly $8 million grant for new stem cell-based AML treatments

The Independent Citizens Oversight Committee of the California Institute for Regenerative Medicine unanimously approved yesterday two grants worth a total of almost $8 million to University of California San Diego School of Medicine researchers investigating novel stem cell-based treatments for acute myeloid leukemia or AML.

4 Dec 2017

New optical ultrasound needle could help visualize heart tissue during keyhole procedures

Heart tissue can be imaged in real-time during keyhole procedures using a new optical ultrasound needle developed by researchers at UCL and Queen Mary University of London.

1 Dec 2017

UT Southwestern researchers take early step toward personalized care for breast cancer

UT Southwestern Medical Center researchers have developed a method to map protein changes that occur in different subtypes of breast cancer cells in response to DNA damage from a new class of chemotherapy drugs.

29 Nov 2017

Study finds unexpected new drug target for acute myeloid leukemia

A study has found an unexpected new drug target for acute myeloid leukemia (AML) that could open new avenues to develop effective treatments against this potentially lethal disease.

27 Nov 2017

Study identifies signaling pathway essential for growth of new blood vessels

A new study led by researchers at Sanford Burnham Prebys Medical Discovery Institute (SBP) identifies a signaling pathway that is essential for angiogenesis, the growth of new blood vessels from pre-existing vessels.

23 Nov 2017

Anti-diabetic drug can enhance repair of UV-induced DNA damage in cells of ‘Moon children’

The destructive force of UV radiation on DNA molecules is only fully visible, when repair mechanisms fail: patients with the rare genetic disease Xeroderma pigmentosum - also known as 'Moon children' - develop inflammations upon exposure to only small amounts of sunlight, rough-surfaced growths and eventually skin cancer occurs often in early age.

21 Nov 2017

Preclinical study shows clear path toward effective treatment for rare bone disease

Researchers at Sanford Burnham Prebys Medical Discovery Institute have led a preclinical study demonstrating that the drug palovarotene suppresses the formation of bony tumors (osteochondromas) in models of multiple hereditary exostoses (MHE).

20 Nov 2017

ESMO Consortium Study advocates for equal access to quality cancer treatment across Asia

The European Society for Medical Oncology opened its 3rd ESMO Asia Congress today, once again in Singapore, attracting close to 3000 regional and international cancer doctors with leading researchers and experts to promote advances in science, diagnosis, treatment, and best practices for cancer patients in Asia.

20 Nov 2017

UZH leads Europe's largest research on aging

What began in 2012 is now entering its final stages: Europe's largest study on aging. The international research network behind the DO-HEALTH study is led by Heike Bischoff-Ferrari, Professor of Geriatric Medicine and Aging Research at the University of Zurich, and Head of the Department of Geriatrics at the UniversityHospital Zurich and the Waid City Hospital in Zurich, Switzerland.

20 Nov 2017

Hibernating ground squirrels offer clues to fight against stroke-induced brain damage

In the fight against brain damage caused by stroke, researchers have turned to an unlikely source of inspiration: hibernating ground squirrels.

17 Nov 2017

Drug used to prevent and treat malaria may also be effective for Zika virus

A new collaborative study led by researchers at Sanford Burnham Prebys Medical Discovery Institute and UC San Diego School of Medicine has found that a medication used to prevent and treat malaria may also be effective for Zika virus.

17 Nov 2017

Researchers develop computer program to find new indications for old drugs

Researchers at the Case Comprehensive Cancer Center at Case Western Reserve University School of Medicine have developed a computer program to find new indications for old drugs.

16 Nov 2017

New implantable muscle stimulator aims to prevent pressure ulcers, deep tissue injuries

A team of researchers led by Kath Bogie, DPhil (PhD), a biomedical engineer and associate professor of orthopaedics and biomedical engineering at Case Western Reserve University School of Medicine, and colleagues from Case Western Reserve and other institutions, has received a $1.8M, three-year grant from the U.S. Department of Defense to develop an implantable muscle stimulator for preventing pressure ulcers and deep tissue injuries to the buttocks.

15 Nov 2017

Scientists identify critical player in Alzheimer's disease pathogenesis

Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that a protein called membralin is critical for keeping Alzheimer's disease pathology in check.

14 Nov 2017

Researchers shed light on link between cholera outbreaks affecting African and American continents

Researchers at the Institut Pasteur and the Wellcome Trust Sanger Institute, in collaboration with several other international institutions, recently published two studies tracing the history of cholera outbreaks in Africa, Latin America and the Caribbean from the last 60 years.

13 Nov 2017

New biomarker could lead to early detection of Alzheimer's disease

Researchers at Sanford Burnham Prebys Medical Discovery Institute have identified a peptide that could lead to the early detection of Alzheimer's disease (AD).

10 Nov 2017

SBP researchers identify new protective function for brain protein genetically linked to Alzheimer's

Researchers at Sanford Burnham Prebys Medical Discovery Institute have identified a new protective function for a brain protein genetically linked to Alzheimer's. The findings, published in the Journal of Experimental Medicine, could inform novel treatment strategies.

7 Nov 2017

Translation News and Research

Research findings offer path for drug discovery to treat hyperaldosteronism

Overcoming Challenges of Assays of Complex Cellular Models with Real-Time Live-Cell Analysis

OICR announces innovative initiative to drive development of new cancer therapies

UC San Diego researchers receive nearly $8 million grant for new stem cell-based AML treatments

New optical ultrasound needle could help visualize heart tissue during keyhole procedures

UT Southwestern researchers take early step toward personalized care for breast cancer

Study finds unexpected new drug target for acute myeloid leukemia

Study identifies signaling pathway essential for growth of new blood vessels

Anti-diabetic drug can enhance repair of UV-induced DNA damage in cells of ‘Moon children’

Preclinical study shows clear path toward effective treatment for rare bone disease

ESMO Consortium Study advocates for equal access to quality cancer treatment across Asia

UZH leads Europe's largest research on aging

Hibernating ground squirrels offer clues to fight against stroke-induced brain damage

Drug used to prevent and treat malaria may also be effective for Zika virus

Researchers develop computer program to find new indications for old drugs

New implantable muscle stimulator aims to prevent pressure ulcers, deep tissue injuries

Scientists identify critical player in Alzheimer's disease pathogenesis

Researchers shed light on link between cholera outbreaks affecting African and American continents

New biomarker could lead to early detection of Alzheimer's disease

SBP researchers identify new protective function for brain protein genetically linked to Alzheimer's

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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