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Research findings could lead to new ways of preventing or treating organ transplant rejection

Research findings could lead to new ways of preventing or treating organ transplant rejection

An international team led by researchers from the University of Pittsburgh School of Medicine found that targeting certain donor cells lowered the risk of organ rejection in mice that underwent kidney and heart transplants. [More]
Assigning barcode to stem cells makes it possible to monitor large blood cell populations

Assigning barcode to stem cells makes it possible to monitor large blood cell populations

By assigning a barcode to stem cells, researchers at Lund University in Sweden have made it possible to monitor large blood cell populations as well as individual blood cells, and study the changes over time. [More]
Transient dose of rapamycin in middle age can increase life expectancy, improve measures of healthy aging

Transient dose of rapamycin in middle age can increase life expectancy, improve measures of healthy aging

Geroscience researchers studying the biology of aging briefly treated middle-aged mice with the drug rapamycin to gauge the long-term effects of short-term therapy on health and longevity. [More]
Penn researchers uncover strategy to reverse effects of dyskeratosis congenita

Penn researchers uncover strategy to reverse effects of dyskeratosis congenita

Dyskeratosis congenita, or DC, is a rare, inherited disease for which there are limited treatment options and no cure. [More]
Complex instructions, caregiver empathy may play key role in raising post-transplant anxiety

Complex instructions, caregiver empathy may play key role in raising post-transplant anxiety

Some anxiety is perfectly normal for kidney transplant patients, but new research suggests that medical staff can help patients feel more at ease when they leave the hospital and that could decrease the chances they'll be readmitted. [More]
Stem cells derived from bone marrow provide better quality of life to transplant patients

Stem cells derived from bone marrow provide better quality of life to transplant patients

A large, nationwide study published in the journal JAMA Oncology found that people who received transplants of cells collected from a donor's bone marrow the original source for blood stem cell transplants, developed decades ago had better self-reported psychological well-being, experienced fewer symptoms of a common post-transplant side effect called graft-vs.-host disease and were more likely to be back at work five years after transplantation than those whose transplanted cells were taken from the donor's bloodstream. [More]
German scientists develop new approach to prevent GvHD after bone marrow transplants

German scientists develop new approach to prevent GvHD after bone marrow transplants

Scientists in Germany have developed a new approach that may prevent leukemia and lymphoma patients from developing graft-versus-host disease (GvHD) after therapeutic bone marrow transplants. [More]
FDA grants Orphan Drug Designation to CD4CAR therapy for treatment of peripheral T-cell lymphoma

FDA grants Orphan Drug Designation to CD4CAR therapy for treatment of peripheral T-cell lymphoma

iCell Gene Therapeutics today (Aug. 11) announced that the Food and Drug Administration has granted Orphan Drug Designation for its chimeric antigen receptor engineered T-cells directed against the target protein CD4 (CD4CAR) for the treatment of peripheral T-cell lymphoma (PTCL). [More]
Scientists find new functions of ANG protein that plays key role in regulation of blood cell formation

Scientists find new functions of ANG protein that plays key role in regulation of blood cell formation

Tufts Medical Center and Tufts University scientists have found exciting, new functions of the protein angiogenin that play a significant role in the regulation of blood cell formation, important in bone marrow transplantation and recovery from radiation-induced bone marrow failure. [More]
Antioxidant compound could be effective to combat immune rejection after islet transplantation

Antioxidant compound could be effective to combat immune rejection after islet transplantation

A team of researchers has found that doses of bilirubin help provide suppression of the immune response following islet transplantation in mouse models. [More]
New disease gene linked to shortened telomeres appears to raise risk of pulmonary fibrosis-emphysema

New disease gene linked to shortened telomeres appears to raise risk of pulmonary fibrosis-emphysema

Johns Hopkins researchers say they have identified a new disease gene that, when mutated, appears to increase the risk in a small number of people of developing emphysema and a lung-scarring condition known as pulmonary fibrosis. [More]
Scientists improve potential weapon to fight against autoimmune disorders

Scientists improve potential weapon to fight against autoimmune disorders

With a trick of engineering, scientists at the Gladstone Institutes improved a potential weapon against inflammation and autoimmune disorders. Their work could one day benefit patients who suffer from inflammatory bowel disease or organ transplant rejection. [More]
Study shows universal health insurance may mitigate surgical disparities for African Americans

Study shows universal health insurance may mitigate surgical disparities for African Americans

A new study from Brigham and Women's Hospital utilized claims data from more than 630,000 patients living in the state of California and found no significant differences in post-operative complications or mortality between African American patients and White patients who were treated in a universally insured military health system. [More]
DASH-style diet could help lower risk of developing chronic kidney disease

DASH-style diet could help lower risk of developing chronic kidney disease

People who ate a diet high in nuts and legumes, low-fat dairy, whole grains, fruits, and vegetables and low in red and processed meat, sugar-sweetened beverages and sodium were at a significantly lower risk of developing chronic kidney disease over the course of more than two decades, new Johns Hopkins Bloomberg School of Public Health research suggests. [More]
African-American men treated with ADT for prostate cancer suffer from high mortality rates

African-American men treated with ADT for prostate cancer suffer from high mortality rates

In a retrospective study analyzing patients' medical records, researchers at Brigham and Women's Hospital found that patients' race significantly affected their longevity by increasing the likelihood of death after receiving androgen deprivation therapy (ADT). [More]
New lung scanning platform holds potential to improve treatment for people with lung disease

New lung scanning platform holds potential to improve treatment for people with lung disease

New lung scanning technology developed at Monash University has the potential to transform treatment for millions of people with lung disease in Australia and around the world. [More]
Heart-resident macrophages promote neutrophil recruitment after ischemic injury

Heart-resident macrophages promote neutrophil recruitment after ischemic injury

Tissue injury, such as occurs in response to a lack of oxygen, promotes an influx of immune cells to the site of damage. [More]
Stranger’s organ donation instigates six-way kidney swap

Stranger’s organ donation instigates six-way kidney swap

A stranger began a chain of events that eventually saved the lives of six people in desperate need of new kidneys. Her organ donation triggered a six-way kidney swap at Houston Methodist Hospital in July, the second largest of its kind performed at one institution in Texas. [More]
Cell-free DNA test could help identify liver transplant patients with acute rejection

Cell-free DNA test could help identify liver transplant patients with acute rejection

Today, researchers presented findings at the 68th AACC Annual Scientific Meeting that DNA found circulating in the bloodstream—known as cell-free DNA—can be used to identify liver transplant patients with acute rejection with greater accuracy than conventional liver function tests. [More]
Smoking reduces lifespans and overall chances of kidney transplantation in dialysis patients

Smoking reduces lifespans and overall chances of kidney transplantation in dialysis patients

Dialysis patients who smoke are much less likely to receive a life-saving kidney transplant and much more likely to die sooner according to researchers from the Health Research Institute (HRI) at the University of Limerick and UL’s Graduate Entry Medical School. [More]
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