Tryptophan News and Research

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Tryptophan is one of the 20 standard amino acids, as well as an essential amino acid in the human diet.

Gut-friendly psychobiotics could brighten moods and fight depression

Review uncovers that psychobiotics may offer supportive treatment for depression by restoring gut microbiome balance and positively influencing the microbiome-gut-brain axis, which is crucial for mental health and well-being.

8 Apr 2024

Balanced diet linked to better brain health and cognition, large-scale study shows

Study utilizing the UK Biobank data identifies four dietary patterns, revealing the balanced diet subtype promotes superior cognitive functions and mental health outcomes compared to starch-free, vegetarian, or high-protein-low-fiber diets.

3 Apr 2024

An ActRIIA fusion protein got FDA approved for PAH treatment

On March 26th, the US FDA granted approval for Merck’s WINREVAIR™ (sotatercept-csrk), marking a significant milestone in pulmonary arterial hypertension (PAH) treatment. PAH, characterized by elevated blood pressure in the arteries connecting the heart and lungs, poses a grave risk of heart failure.

From Sino Biological Inc. 28 Mar 2024

Study reveals trigonelline as a therapeutic agent for mitochondrial dysfunction in aging

Sarcopenia is the age-related decline in skeletal muscle due to the wasting of myofiber.

26 Mar 2024

Natural molecule trigonelline can help to improve muscle health and function

A research consortium led by Nestlé Research in Switzerland and the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine) made a recent discovery that the natural molecule trigonelline present in coffee, fenugreek, and also in the human body, can help to improve muscle health and function.

22 Mar 2024

Unique bacteria colonize the gut shortly after birth and make serotonin to educate gut immune cells

A recent study revealed that neonatal gut bacteria produce serotonin and down-regulate monoamine oxidase A (MOA) to limit serotonin breakdown, thereby promoting immune tolerance.

20 Mar 2024

Gut bacteria and tryptophan diet can play a protective role against pathogenic E. coli

Gut bacteria and a diet rich in the amino acid tryptophan can play a protective role against pathogenic E. coli, which can cause severe stomach upset, cramps, fever, intestinal bleeding and renal failure, according to a study published March 13 in Nature.

14 Mar 2024

Tryptophan digestion by gut microbiome spurs arthritis inflammation

A University of Colorado Department of Medicine faculty member says she and her colleagues have identified the means in which bacteria in the digestive system can break down tryptophan in the diet into an inflammatory chemical that primes the immune system towards arthritis.

7 Mar 2024

Study reveals mechanisms behind antidepressant effects of diabetes drug

Research in animals has shown that the diabetes drug dulaglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist may reduce symptoms of depression.

6 Mar 2024

How can food influence the severity of menopausal hot flashes?

Mechanisms and nutrients related to menopause hot flashes.

28 Feb 2024

New study defines clinical phenotype of Post-infectious ME/CFS, highlighting unique biomarker insights

The pathophysiological mechanisms of PI myalgic encephalitis/chronic fatigue syndrome (ME/CFS).

23 Feb 2024

Study provides evidence that antidepressant use in pregnancy affects child's brain development

A new study explored synapse maturation in the PFC of mice when exposed to 5-HT, shedding light on the link between the chemical and future behavioral changes.

19 Feb 2024

Study explores the mediatory role of gut microbiota in metabolic syndrome and sleep disorders

Researchers described gut microbiota and metabolic alterations common to metabolic syndrome (MetS) and sleep disorders.

31 Jan 2024

From gut to brain: How diet can influence Alzheimer's and Parkinson's outcomes

Diet modification and alterations in the intestinal microbial population could impact the disease course of Alzheimer’s and Parkinson’s diseases.

23 Jan 2024

Amino acid nanoparticles show promise for cancer treatment

Amino acids, such as tyrosine and tryptophan, are the fundamental building blocks that make up proteins.

8 Jan 2024

Gut microbiota: the new frontier in Alzheimer’s disease research and therapy

The current evidence of the role of gut microbiota in Alzheimer’s disease (AD) pathogenesis.

8 Jan 2024

IDO2 deficiency in mice leads to behavioral abnormalities resembling autism spectrum disorder

Over the past decades, scientists have made substantial progress unveiling the underlying mechanisms behind many psychiatric disorders.

4 Jan 2024

Neutrophils: Unraveling their multifaceted roles in inflammatory bowel disease and gut microbiota interactions

Research delves into the complex roles of neutrophils in inflammatory bowel disease (IBD), exploring their diverse functions and interactions with the gut microbiota and emphasizing the need for targeted therapies based on these insights.

27 Dec 2023

How a malaria drug may hold the key to ending malnutrition's cycle of devastation

Wars, drought, displacement, and instability are causing a dramatic increase in the number of pregnant and breastfeeding women around the world who suffer from malnutrition.

20 Dec 2023

Oxidized amino acids signal damaged photosynthesis proteins for repair

Photosynthesis refers to the fundamental biological process of the conversion of light energy into chemical energy by chlorophyll (a green pigment) containing plants.

18 Dec 2023