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Boehringer grants volasertib 'orphan drug designation' for treatment of patients with AML

Boehringer grants volasertib 'orphan drug designation' for treatment of patients with AML

Boehringer Ingelheim announced today that the US Food and Drug Administration (FDA) and the European Commission have granted volasertib* 'orphan drug designation' for the treatment of patients with acute myeloid leukaemia (AML). [More]
Researchers uncover mechanism that may help explain severe forms of schistosomiasis

Researchers uncover mechanism that may help explain severe forms of schistosomiasis

‚ÄčResearchers at the Sackler School of Graduate Biomedical Sciences at Tufts and Tufts University School of Medicine (TUSM) have uncovered a mechanism that may help explain the severe forms of schistosomiasis, or snail fever, which is caused by schistosome worms and is one of the most prevalent parasitic diseases in the world. The study in mice, published online in The Journal of Immunology, may also offer targets for intervention and amelioration of the disease. [More]
Scientists discover structure of protein that helps common fungal pathogen to infect humans

Scientists discover structure of protein that helps common fungal pathogen to infect humans

A team that includes scientists from the School of Medicine at The University of Texas Health Science Center at San Antonio, Johns Hopkins University and St. Mary's University reported the structure of a protein that helps a common fungus to infect the body. [More]

Massage therapy alleviates muscle soreness and improves general blood flow

Massage therapy improves general blood flow and alleviates muscle soreness after exercise, according to a study by researchers at the University of Illinois at Chicago. [More]
NIH-funded researchers develop novel tools to learn how astrocytes listen in on neurons

NIH-funded researchers develop novel tools to learn how astrocytes listen in on neurons

‚ÄčEverything we do - all of our movements, thoughts and feelings - are the result of neurons talking with one another, and recent studies have suggested that some of the conversations might not be all that private. [More]
Freiburg researchers discover molecule that smuggles toxins from intestinal pathogens into human cells

Freiburg researchers discover molecule that smuggles toxins from intestinal pathogens into human cells

Prof. Dr. Dr. Klaus Aktories and Dr. Panagiotis Papatheodorou from the Institute of Experimental and Clinical Pharmacology and Toxicology of the University of Freiburg have discovered the receptor responsible for smuggling the toxin of the bacterium Clostridium perfringens into the cell. [More]

Professor from INRS receives NIH grant to explore biomedical potential in field of oncology

Professor Nicolas Doucet of the Centre INRS-Institut Armand-Frappier has just received a research grant from the National Institutes of Health (NIH) in the amount of nearly US$600,000. The 5-year grant is to pursue cutting-edge research in the workings of tiny proteins called RNases and to explore their biomedical potential in the field of oncology as well as in inflammation and asthma. [More]

Scientists trying to merge millions of patient medical records

The attempt includes collecting and connecting terabytes of patient medical records from every patient recently treated at one of New York's major hospital centers. Meanwhile in Kansas, a council discusses ways to regulate so-called "secondary use" of patient health data. [More]
Iconic Therapeutics completes $20 million Series B-1 equity financing

Iconic Therapeutics completes $20 million Series B-1 equity financing

Iconic Therapeutics, Inc., a biotechnology company focused on developing therapeutics for serious eye disorders, announced today that it has successfully completed a $20 million Series B-1 equity financing from new investors MPM Capital, Lundbeckfond Ventures, and H.I.G. BioVentures. [More]

Baxter reports topline results from BAX 111 Phase 3 trial for treatment of von Willebrand disease

Baxter International Inc. today announced topline results from a Phase 3 clinical trial evaluating the safety, efficacy and pharmacokinetics (PK) of BAX 111. BAX 111 is a recombinant von Willebrand factor (rVWF) under investigation for the treatment of bleeding episodes in patients with von Willebrand disease, the most common type of inherited bleeding disorder. [More]

First Edition: April 16, 2014

Today's headlines include a report detailing how changes in the Census Bureau's annual survey could mask the health law's impact. [More]
Scientists report new approach to restore penicillin's combat effectiveness against bacterial infections

Scientists report new approach to restore penicillin's combat effectiveness against bacterial infections

Penicillin, one of the scientific marvels of the 20th century, is currently losing a lot of battles it once won against bacterial infections. But scientists at the University of South Carolina have just reported a new approach to restoring its combat effectiveness, even against so-called "superbugs." [More]

Harvard successfully transplants regenerated esophagus into rat using bioreactor

Harvard Apparatus Regenerative Technology, Inc., a clinical stage biotechnology company developing regenerated organs for transplant, initially focused on the trachea, announces that a research team led by Paolo Macchiarini, MD, PhD at Karolinska Institutet in Sweden has successfully transplanted a regenerated esophagus into a rat using a bioreactor developed by HART. [More]

Dental researchers find new way to study how mouth's natural defenses ward off infection, inflammation

Case Western Reserve University dental researchers have found a less invasive way to extract single rare immune cells from the mouth to study how the mouth's natural defenses ward off infection and inflammation. [More]
WHI study shows no significant link between vitamin D levels and menopause symptoms

WHI study shows no significant link between vitamin D levels and menopause symptoms

A new study from the Women's Health Initiative shows no significant connection between vitamin D levels and menopause symptoms. The study was published online today in Menopause, the journal of The North American Menopause Society. [More]
Researchers develop more accurate tool for diagnosing even mild cases of asthma

Researchers develop more accurate tool for diagnosing even mild cases of asthma

Using just a single drop of blood, a team of University of Wisconsin-Madison researchers has developed a faster, cheaper and more accurate tool for diagnosing even mild cases of asthma. [More]
Genetically modified neural stem cells offer potential treatment for Alzheimer's disease

Genetically modified neural stem cells offer potential treatment for Alzheimer's disease

UC Irvine neurobiologists have found that genetically modified neural stem cells show positive results when transplanted into the brains of mice with the symptoms and pathology of Alzheimer's disease. The pre-clinical trial is published in the journal Stem Cells Research and Therapy, and the approach has been shown to work in two different mouse models. [More]
Researchers explore new standard of continuity of care for stroke patients

Researchers explore new standard of continuity of care for stroke patients

A new study from the Faculty of Medicine & Dentistry is looking at nurse- and pharmacist-led interventions to improve the standard of care for patients who have suffered minor stroke or transient ischemic attack, also known as "mini stoke." [More]
Akebia completes enrollment in ongoing 200-patient Phase 2b study of AKB-6548

Akebia completes enrollment in ongoing 200-patient Phase 2b study of AKB-6548

Akebia Therapeutics, Inc., a biopharmaceutical company focused on the development of novel proprietary therapeutics based on hypoxia-inducible factor (HIF) biology and the commercialization of these products for patients with kidney disease, today announced it has completed enrollment in its ongoing 200-patient Phase 2b study of AKB-6548 for the treatment of anemia associated with chronic kidney disease (CKD) in patients who are not dependent on dialysis. [More]

FDA approves GSK's Tanzeum as once-weekly treatment for type 2 diabetes

GlaxoSmithKline plc today announced that the US Food and Drug Administration has approved Tanzeum (albiglutide) for injection, for subcutaneous use, as a once-weekly treatment for type 2 diabetes. Tanzeum has been approved as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. [More]