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Nanoparticle bling could increase sensitivity of test strips for better cancer detection

The most common test strip people might think of for diagnosis is a home pregnancy test. Pregnant women have steadily increasing levels of the biomarker human chorionic gonadotropin (hCG), which is easily detectable in urine and a thin, colorful strip of antibodies will appear when hCG is present.

13 Sep 2017

Study confirms tattoo nanoparticles migrate around the body

A study conducted by a team of scientists from Germany and the European Synchrotron Radiation Facility (ESRF), France, found that the elements which constitute the tattoos’ ink reach the lymph nodes by travelling inside the body in micro and nanoparticle forms.

13 Sep 2017

Japanese researchers find new way for increasing effectiveness of drug delivery to brain tumors

For a cancer drug to be successful, it needs to reach the malignant tumor site. Researchers in Japan have now found a way for increasing the effectiveness of drug delivery to certain types of brain tumors, by packing epirubicin, a known antitumor agent, in specially designed polymeric micelles.

13 Sep 2017

NIH awards $15 million to develop 3D microphysiological system platforms that model human disease

More than 60 percent of investigational drugs fail in human clinical trials due to a lack of effectiveness, despite promising pre-clinical studies using cell and animal research models.

13 Sep 2017

Phthalate levels in expectant fathers influence sperm epigenetics, study suggests

Early results from a larger, ongoing study led by environmental health scientist Richard Pilsner at the University of Massachusetts Amherst suggest that phthalate levels in expectant fathers have an effect on couples' reproductive success via epigenetic modifications of sperm DNA.

12 Sep 2017

Human cell-based methods could better identify asthma-causing chemicals, research suggests

Chemicals that could potentially cause asthma through an immune reaction could be better identified with human cell- and computer-based test methods, according to a new research paper co-authored by the Physicians Committee's Kristie Sullivan, M.P.H., in Applied In Vitro Toxicology.

11 Sep 2017

CFDA's NIFDC and IIVS re-affirm, expand partnership to bring non-animal test methods to China

Bo Li, Director General Director of the CFDA's National Institute for Food and Drug Control and Erin Hill, President of US based non-profit, Institute for In Vitro Sciences, Inc., signed a Memorandum of Understanding to bring non-animal test methods to China for the regulation of cosmetics and ingredients.

7 Sep 2017

Differentiating sepsis and systemic inflammatory response syndrome using biomarkers

Firstly, it is necessary to make a distinction between systemic inflammation and Systemic Inflammatory Response Syndrome (SIRS). SIRS consists of changes in clinical signs including an abnormal body temperature, increased heart rate, increased respiratory rate, an abnormal white cell count (either decreased or elevated), or an increase in band neutrophils.

7 Sep 2017

Study describes link between key melanoma signaling pathway and novel class of drugs

Results of a study by The Wistar Institute have described a correlation between a key melanoma signaling pathway and a novel class of drugs being tested in the clinic as adjuvant therapy for advanced melanoma, providing useful information for a more effective use of this type of treatment.

7 Sep 2017

Novel compounds found to be highly effective in preventing transmission of malaria parasites

Significant headway has been made in controlling malaria. However, two vexing problems remain: currently available treatments are unable to block transmission of the parasite that causes the disease, and the parasite often becomes resistant to drugs.

7 Sep 2017

Researcher develops bone marrow models to study hematological and musculoskeletal diseases

For her research on the development of hematological and musculoskeletal disorders, Dr. Cornelia Lee-Thedieck, scientist at Karlsruhe Institute of Technology, is awarded an ERC Starting Grant: The European Research Council decided to fund her project "bloodANDbone" with EUR 1.5 million for five years. At KIT's Institute of Functional Interfaces, Lee-Thedieck develops models of the human bone marrow to study the regeneration of blood and bone by stem cells and how this regeneration is disturbed in diseases like leukemia or bone metastases.

6 Sep 2017

Research provides new insights into secret life of bacteria

Bacterial infections are the number one cause of death in hospital patients in the United States, and antibiotic-resistant bacteria are on the rise, causing tens of thousands of deaths every year.

6 Sep 2017

Antibiotics may kill bacteria differently in vitro vs in vivo

Understanding exactly how antibiotics work (or don’t work) is crucial for developing alternative treatment strategies, not only to target new “superbugs,” but also to make existing drugs more effective against their targets.

5 Sep 2017

FDA grants clearance for first 2D digital mammography system with patient-assisted compression

Today, the U.S. Food and Drug Administration cleared the first 2D digital mammography system that allows patients to increase or decrease the amount of compression applied to their own breast before the mammogram x-ray is taken.

1 Sep 2017

Pfizer receives FDA approval for new therapy to treat adults and children with AML

Pfizer Inc. today announced that the U.S. Food and Drug Administration approved MYLOTARG (gemtuzumab ozogamicin) for adults with newly diagnosed CD33-positive acute myeloid leukemia (AML), and adults and children 2 years and older with relapsed or refractory CD33-positive AML.

1 Sep 2017

Placenta-on-a-chip device mimics microenvironment of malaria in the womb to develop treatments

Malaria, one of the most severe public health problems, affected 212 million people worldwide in 2015. This life-threatening disease is caused by parasites that are transmitted to humans through the bites of infected female Anopheles mosquitoes.

29 Aug 2017

New study compares experiences of women undergoing IVF either to become pregnant or for money

An individual's reason for undergoing a medical intervention -- be it to prevent or treat disease, earn money, or to have a child -- may result in variations in the bodily experience of the patient, Yale researchers have found.

26 Aug 2017

Study examines link between flame retardants and pregnancy outcomes in women undergoing fertility treatments

Women with higher urinary concentrations of a common type of flame retardant had reduced likelihood of clinical pregnancy and live birth than those with lower concentrations, according to researchers at Harvard T.H. Chan School of Public Health.

26 Aug 2017

Study reveals impact of flame retardants on reduced clinical pregnancy outcomes

A study conducted by a team of researchers at the Harvard T.H. Chan School of Public Health has found that for women with an increased concentration of a common type of flame retardant in their urine, there is a decreased possibility of clinical pregnancy as well as live birth when compared to those with a lower concentration.

25 Aug 2017

Studies aim to better understand potential health benefits of red raspberries

Initial findings from several studies - including both human subjects and animals - on the potential health benefits of red raspberries were presented earlier this year at the 2017 Experimental Biology conference in Chicago.

24 Aug 2017

in vitro News and Research

Nanoparticle bling could increase sensitivity of test strips for better cancer detection

Study confirms tattoo nanoparticles migrate around the body

Japanese researchers find new way for increasing effectiveness of drug delivery to brain tumors

NIH awards $15 million to develop 3D microphysiological system platforms that model human disease

Phthalate levels in expectant fathers influence sperm epigenetics, study suggests

Human cell-based methods could better identify asthma-causing chemicals, research suggests

CFDA's NIFDC and IIVS re-affirm, expand partnership to bring non-animal test methods to China

Differentiating sepsis and systemic inflammatory response syndrome using biomarkers

Study describes link between key melanoma signaling pathway and novel class of drugs

Novel compounds found to be highly effective in preventing transmission of malaria parasites

Researcher develops bone marrow models to study hematological and musculoskeletal diseases

Research provides new insights into secret life of bacteria

Antibiotics may kill bacteria differently in vitro vs in vivo

FDA grants clearance for first 2D digital mammography system with patient-assisted compression

Pfizer receives FDA approval for new therapy to treat adults and children with AML

Placenta-on-a-chip device mimics microenvironment of malaria in the womb to develop treatments

New study compares experiences of women undergoing IVF either to become pregnant or for money

Study examines link between flame retardants and pregnancy outcomes in women undergoing fertility treatments

Study reveals impact of flame retardants on reduced clinical pregnancy outcomes

Studies aim to better understand potential health benefits of red raspberries

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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